Bilateral Simultaneous Femoral Fragility Fractures after Long - Term Alendronate Therapy

2016 ◽  
Vol 24 (1) ◽  
pp. 20-23
Author(s):  
Yalçın Turhan ◽  
Yavuz Geçer ◽  
Zekeriya O. Karaduman
Keyword(s):  
Fragility Fractures

Effects of long-term inhaled corticosteroid treatment on fragility fractures in older women: the Manitoba BMD registry study

2020 ◽  
Vol 31 (6) ◽  
pp. 1155-1162
Author(s):  
B.C. Ng ◽  
W.D. Leslie ◽  
K.M. Johnson ◽  
J.M. FitzGerald ◽  
M. Sadatsafavi ◽  
...  
Keyword(s):  
Older Women ◽  
Fragility Fractures ◽  
Corticosteroid Treatment ◽  
Registry Study ◽  
Inhaled Corticosteroid

Requirements for a Stable Long-Term Result in Surgical Reduction of Vertebral Fragility Fractures

2017 ◽  
Vol 105 ◽  
pp. 137-144 ◽  
Author(s):  
Jesús Crespo-Sanjuán ◽  
Francisco Ardura ◽  
Rubén Hernández-Ramajo ◽  
David C. Noriega
Keyword(s):  
Fragility Fractures ◽  
Term Result ◽  
Surgical Reduction ◽  
Long Term Result

scholarly journals Orthogeriatric co-management improves the outcome of long-term care residents with fragility fractures

2016 ◽  
Vol 136 (10) ◽  
pp. 1403-1409 ◽  
Author(s):  
M. Gosch ◽  
Y. Hoffmann-Weltin ◽  
T. Roth ◽  
M. Blauth ◽  
J. A. Nicholas ◽  
...  
Keyword(s):  
Long Term Care ◽  
Fragility Fractures ◽  
Term Care

scholarly journals Short-term and Long-term Orthopaedic Issues in Patients With Fragility Fractures

2011 ◽  
Vol 469 (8) ◽  
pp. 2225-2236 ◽  
Author(s):  
Susan V. Bukata ◽  
Stephen L. Kates ◽  
Regis J. O’Keefe
Keyword(s):  
Fragility Fractures ◽  
Short Term

scholarly journals What is the long-term clinical outcome after fragility fractures of the pelvis? - a CT-based cross-sectional study

Injury ◽  
2021 ◽  
Author(s):  
H. Banierink ◽  
K. ten Duis ◽  
J. Prijs ◽  
K.W. Wendt ◽  
V.M.A. Stirler ◽  
...  
Keyword(s):  
Clinical Outcome ◽  
Fragility Fractures ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional

scholarly journals Incident Fragility Fractures Have a Long‐Term Negative Impact on Health‐Related Quality of Life of Older People: The Canadian Multicentre Osteoporosis Study

2019 ◽  
Vol 34 (5) ◽  
pp. 838-848 ◽  
Author(s):  
Sayem Borhan ◽  
Alexandra Papaioannou ◽  
Olga Gajic‐Veljanoski ◽  
Courtney Kennedy ◽  
George Ioannidis ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Older People ◽  
Negative Impact ◽  
Fragility Fractures ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related

Metabolic bone disease of prematurity: causes, recognition, prevention, treatment and long-term consequences

2019 ◽  
Vol 104 (5) ◽  
pp. F560-F566 ◽  
Author(s):  
Amish Chinoy ◽  
Mohamed Zulf Mughal ◽  
Raja Padidela
Keyword(s):  
Bone Disease ◽  
Metabolic Bone Disease ◽  
Diuretic Therapy ◽  
Fragility Fractures ◽  
Third Trimester ◽  
Phosphate Homeostasis ◽  
Metabolic Bone ◽  
Routine Handling ◽  
Postnatal Factors

Metabolic bone disease of prematurity (MBDP) is characterised by skeletal demineralisation, and in severe cases it can result in fragility fractures of long bones and ribs during routine handling. MBDP arises from prenatal and postnatal factors. Infants who are born preterm are deprived of fetal mineral accumulation, 80% of which occurs in the third trimester. Postnatally, it is difficult to maintain a comparable intake of minerals, and medications, such as corticosteroids and diuretic therapy, lead to bone resorption. With improvements in neonatal care and nutrition, the incidence of MBDP in preterm infants appears to have decreased, although the recent practice of administering phosphate supplements alone will result in secondary hyperparathyroidism and associated bone loss, worsening MBDP. Postnatal immobilisation and loss of placental supply of oestrogen also contribute to skeletal demineralisation. There is no single diagnostic or screening test for MBDP, with pitfalls existing for most radiological and biochemical investigations. By reviewing the pathophysiology of calcium and phosphate homeostasis, one can establish that plasma parathyroid hormone is important in determining the aetiology of MBDP – primarily calcipaenia or phosphopaenia. This will then direct treatment with the appropriate supplements while considering optimal physiological calcium to phosphate ratios.

Rheumatoid Arthritis is a Risk Factor for Refracture in Patients with Fragility Fractures

2021 ◽  
Author(s):  
Hotaka Ishizu ◽  
Hirokazu Shimizu ◽  
Tomohiro Shimizu ◽  
Taku Ebata ◽  
Yuki Ogawa ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Risk Factor ◽  
Propensity Score ◽  
Primary Outcome ◽  
Fragility Fractures ◽  
Increased Risk ◽  
Substantial Risk ◽  
Multivariable Analyses

Abstract Objectives To determine whether patients with rheumatoid arthritis (RA) who have had fragility fractures are at an increased risk of refractures. Methods Patients with fragility fractures who were treated surgically at ten hospitals from 2008 to 2017 and who underwent follow-up for more than 24 months were either categorized into a group comprising patients with RA or a group comprising patients without RA (controls). The groups were matched 1:1 by propensity score matching. Accordingly, 240 matched participants were included in this study. The primary outcome was the refracture rate in patients with RA as compared to in the controls. Multivariable analyses were also conducted on patients with RA to evaluate the odds ratios (ORs) for the refracture rates. Results Patients with RA were significantly associated with increased rates of refractures during the first 24 months (OR: 2.714, 95% confidence interval [95% CI]: 1.015–7.255; P = 0.040). Multivariable analyses revealed a significant association between increased refracture rates and long-term RA (OR: 6.308, 95% CI: 1.195–33.292; P=0.030). Conclusions Patients with RA who have experienced fragility fractures are at an increased risk of refractures. Long-term RA is a substantial risk factor for refractures.

scholarly journals P1748PARATHYROIDECTOMY REMAINS EFFECTIVE FOR TREATING TERTIARY HYPERPARATHYROIDISM: LONG-TERM RESULTS OF A RANDOMIZED STUDY

2020 ◽  
Vol 35 (Supplement_3) ◽  
Author(s):  
Ana Coloma Lopez ◽  
Pablo Moreno ◽  
Jose-Vicente Torregrosa ◽  
Nuria Montero ◽  
Anna Manonelles ◽  
...  
Keyword(s):  
Kidney Transplant ◽  
Serum Calcium ◽  
Randomized Study ◽  
Fragility Fractures ◽  
Long Term Results ◽  
Subtotal Parathyroidectomy ◽  
Tertiary Hyperparathyroidism ◽  
Increased Risk

Abstract Background and Aims Tertiary hyperparathyroidism is a common cause of hypercalcemia after kidney transplant (KT) and has been associated with renal dysfunction, loss bone mineral density and increased risk of fracture, vascular calcification, and increased risk of cardiovascular events. Long clinical management remains controversial. The aim of this study is to evaluate the long-term effectiveness and safety of parathyroidectomy versus cinacalcet in patients with persistent hyperparathyroidism. Method A 12-month prospective, multicenter, randomized study demonstrated than subtotal parathyroidectomy is more effective than cinacalcet for controlling hypercalcemia. Now, we evaluate in the same cohort of patients if this effect is maintained after 5 years of follow-up. Laboratory assessment included serum calcium, serum phosphate, intact parathyroid hormone (iPTH), calcidiol levels, estimated glomerular filtration rate and proteinuria at 2, 3, 4 and 5 year follow-up. Therapeutic details about the use of vitamin D, calcium supplementation and phosphate binders were compiled. Fragility fractures were also collected. Results In total, 24 patients had data available at 5 years, 13 in the cinacalcet group and 11 in the parathyroidectomy group. At 5 years, six of 13 patients in the cinacalcet group and ten of 11 patients in the parathyroidectomy group (p=0.015) showed normocalcemia (Figure 1). Subtotal parathyroidectomy retained a greater reduction of iPTH compared with cinacalcet group (Figure 2). No differences were observed in kidney function and incidence of fragility fractures between both groups. In relation of treatment, 8 of 13 patients in cinacalcet group maintained treatment with cinacalcet after 5 years follow-up. Conclusion Subtotal parathyroidectomy is more effective in long term to maintain normal serum calcium and iPTH compared with cinacalcet in kidney transplant patients with tertiary hyperparathyroidism.

scholarly journals Osteoporotic Hip Fractures: The Burden of Fixation Failure

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
J. M. Broderick ◽  
R. Bruce-Brand ◽  
E. Stanley ◽  
K. J. Mulhall
Keyword(s):  
Hip Fractures ◽  
Length Of Hospital Stay ◽  
Fragility Fractures ◽  
The Elderly ◽  
Osteoporotic Bone ◽  
Ageing Population ◽  
Fixation Failure ◽  
Implant Anchorage

Osteoporotic hip fractures are a major cause of morbidity and mortality in the elderly. Furthermore, reduced implant anchorage in osteoporotic bone predisposes towards fixation failure and with an ageing population, even low failure rates represent a significant challenge to healthcare systems. Fixation failure in fragility fractures of the hip ranges from 5% in peritrochanteric fractures through to 15% and 41% in undisplaced and displaced fractures of the femoral neck, respectively. Our findings, in general, support the view that failed internal fixation of these fragility fractures carries a poor prognosis: it leads to a twofold increase in the length of hospital stay and a doubling of healthcare costs. Patients are more likely to suffer a downgrade in their residential status upon discharge with a consequent increase in social dependency. Furthermore, the marked disability and reduction in quality of life evident before salvage procedures may persist at long-term followup. The risk, of course, for the elderly patient with a prolonged period of decreased functioning is that the disability becomes permanent. Despite this, however, no clear link between revision surgery and an increase in mortality has been demonstrated in the literature.

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