scholarly journals Heroism as the highest therapeutic possibility on the basis of works by Antoni Kępiński

2021 ◽  
Vol 55 (1) ◽  
pp. 213-224
Author(s):  
Artur Mnich
Keyword(s):  
Therapeutic Possibility

scholarly journals Epigenetic Mechanisms Are Involved in the Oncogenic Properties of ZNF518B in Colorectal Cancer

Cancers ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 1433
Author(s):  
Francisco Gimeno-Valiente ◽  
Ángela L. Riffo-Campos ◽  
Luis Torres ◽  
Noelia Tarazona ◽  
Valentina Gambardella ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Chromatin Immunoprecipitation ◽  
Zinc Finger Protein ◽  
Dependent Manner ◽  
Mrna Isoforms ◽  
Histone Methyltransferases ◽  
Therapeutic Possibility ◽  
Cell Dissemination ◽  
Chip Analysis ◽  
Hct116 Cells

The ZNF518B gene, which is up-regulated in colorectal cancer, plays a role in cell dissemination and metastasis. It encodes a zinc-finger protein, which interacts with histone methyltransferases G9A and EZH2. The expression of the two major mRNA isoforms 1 (coding for the full protein) and 2 was quantified by RT-qPCR in a cohort of 66 patients. The effects of silencing ZNF518B on the transcriptome of DLD1 and HCT116 cells were analysed by Clariom-S assays and validated by RT-qPCR. The recruitment of methyltransferases and the presence of H3K27me3 were studied by chromatin immunoprecipitation (ChIP). The ratio (isoform 2)/(isoform 1) negatively correlated with the relapsing of disease. The study of the transcriptome of DLD1 and HCT116 cells revealed that many genes affected by silencing ZNF518B are related to cancer. After crossing these results with the list of genes affected by silencing the histone methyltransferases (retrieved in silico), five genes were selected. ChIP analysis revealed that the recruitment of EZH2 is ZNF518B-dependent in KAT2B, RGS4 and EFNA5; the level of H3K27me3 changes in accordance. G9A also binds RGS4 and PADI3 in a ZNF518B-dependent manner. The results highlight the importance of epigenetics in cancer and open a novel therapeutic possibility, as inhibition of histone methyltransferases may reverse the disease-linked histone marks.

scholarly journals On the Reorganization of Incentive Structure to Promote Delay Tolerance: A Therapeutic Possibility for AD/HD?

2004 ◽  
Vol 11 (1-2) ◽  
pp. 23-28 ◽  
Author(s):  
Edmund J. S. Sonuga-Barke
Keyword(s):  
Delay Aversion ◽  
Incentive Structure ◽  
Attentional Training ◽  
Hyperactivity Disorder ◽  
Incentive Value ◽  
Novel Approach ◽  
Therapeutic Possibility ◽  
Delay Fading ◽  
Executive Deficits ◽  
Cognitive Activities

This paper brings together two recent insights into attention deficit/hyperactivity disorder (AD/HD) to provide the rationale for a novel approach to treatment. First is the suggestion, backed up by data from randomized trials, that training and practice in carefully selected cognitive activities (executive and attentional training) and tasks can provide a way of modifying the processes underlying cognitive, especially executive, deficits in AD/HD. Second, is the idea that AD/HD is a neuropsychologically heterogeneous disorder resulting from motivational alterations, specifically an increased intolerance for delay, as well as executive deficits. The paper builds on these two insights to explore the possibility that the motivational alterations underpinning delay aversion can be modified through specific training regimes in a way equivalent to that found with executive and attentional training. The requirements for such an approach are set out. Delay fading is proposed as a possible basis for reorganizing delay experience, altering the incentive value of delay (e.g., increasing tolerance for delay), thereby reducing AD/HD symptoms.

scholarly journals Circular RNA circ-CDYL sponges miR-1180 to elevate yes-associated protein in multiple myeloma

2020 ◽  
Vol 245 (11) ◽  
pp. 925-932 ◽  
Author(s):  
Fang Chen ◽  
Xiaohui Wang ◽  
Shuang Fu ◽  
Shaokun Wang ◽  
Yu Fu ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Tumor Model ◽  
Circular Rna ◽  
Xenograft Tumor ◽  
Functional Assays ◽  
Xenograft Tumor Model ◽  
Therapeutic Possibility ◽  
Plasma Depletion ◽  
Potential Therapeutic Intervention

The covalently closed circular RNA has recently been proposed as a pivotal player in tumorigenesis. In the current study, we found that circ-CDYL was notably elevated in multiple myeloma tissue and plasma samples and had good diagnostic and prognostic efficacy. Functional assays showed that circ-CDYL enhanced the viability and DNA synthesis of multiple myeloma cells and inhibited apoptosis. Mechanically, cytoplasmic circ-CDYL was co-localized with miR-1180, and circ-CDYL absorbed miR-1180 to upregulate yes-associated protein (YAP), thereby facilitating multiple myeloma progression. Importantly, we further confirmed the existence of this circ-CDYL/miR-1180/YAP regulatory axis in vivo by using the xenograft tumor model. Taken together, our data demonstrate that circ-CDYL is novel promoter of multiple myeloma, and targeting circ-CDYL and its associated network implicates the therapeutic possibility for multiple myeloma patients. Impact statement Multiple myeloma (MM) is an extremely complex and heterogeneous disease, and its pathogenesis is poorly understood. Here, we described an important MM-related circular RNA (circRNA), circ-CDYL. It was remarkably increased in both MM cells and plasma. Depletion of circ-CDYL evidently stunted MM growth. Circ-CDYL could absorb miR-1180 and alleviated the repression of miR-1180 on YAP, leading to increased YAP expression, ultimately triggering MM uncontrolled growth. Therefore, our findings advance the understanding of MM pathogenesis, and also raise the possibility of considering circ-CDYL as a potential therapeutic intervention for MM.

scholarly journals Palliative care to the cancer patient: reflections according to Paterson and Zderad's view

2007 ◽  
Vol 15 (2) ◽  
pp. 350-354
Author(s):  
Míria Conceição Lavinas Santos ◽  
Lorita Marlena Freitag Pagliuca ◽  
Ana Fátima Carvalho Fernandes
Keyword(s):  
Quality Of Life ◽  
Palliative Care ◽  
Cancer Patient ◽  
Nursing Theory ◽  
Therapeutic Possibility ◽  
Reflective Study

This reflective study presents the approach of the Nursing Palliative Care to the cancer patient without therapeutic possibility according to the Paterson and Zderad's Humanistic Nursing Theory. The palliative care aims to provide the patient without therapeutic possibility and his family better quality of life. When the nurse, in addition to delivering palliative care to the cancer patient, uses the Humanistic Theory, (s)he starts to recognize each person as a singular existence. This recognition permits one to understand the person's meaning in the process of his(er) disease.

Therapeutic possibility of human fetal cartilage-derived progenitor cells in rat arthritis model

2015 ◽  
Vol 12 (S2) ◽  
pp. 147-154 ◽  
Author(s):  
Su Jeong Lee ◽  
Hyun Ju Oh ◽  
Minh-Dung Truong ◽  
Kyi Beom Lee ◽  
Jiyoung Kim ◽  
...  
Keyword(s):  
Progenitor Cells ◽  
Arthritis Model ◽  
Therapeutic Possibility

scholarly journals Copaiba oil in experimental wound healing in horses

2017 ◽  
Vol 47 (4) ◽  
Author(s):  
Flavia de Almeida Lucas ◽  
Adriana Lima Kandrotas ◽  
Eugenio Nardin Neto ◽  
Carlos Eduardo de Siqueira ◽  
Gabriela Santo André ◽  
...  
Keyword(s):  
Wound Healing ◽  
Sodium Chloride ◽  
Treatment Group ◽  
Control Group ◽  
Wound Therapy ◽  
Experimental Conditions ◽  
Therapeutic Possibility ◽  
Copaiba Oil ◽  
The Mean ◽  
Made In

ABSTRACT: The aim of this study was to evaluate the effects of 10% copaiba oil in experimentally induced wounds in horses. Four wounds were made in the lumbar and metacarpal regions of eight adult horses. In the treatment group, the wounds received 10% copaiba oil and in the control group 0.9% sodium chloride, in the daily dressing for 21 days. The wounds were evaluated three, 7, 14, and 21 days postoperatively. No significant differences were observed between the groups. The mean lumbar wound contraction rates were 80.54% and 69.64%, for the control and treated groups, respectively. For the wounds in the metacarpal region, these averages were 44.15% and 52.48%, respectively. Under the experimental conditions of the present study, it is concluded that 10% copaiba oil has beneficial in wound healing in the equine species and suggest that copaiba oil can be used as a therapeutic possibility in equine wound therapy.

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