The USE Of Actigraphy for Evaluating Severity and Effects of Neurological Diseases

10.12737/7282 ◽  
2014 ◽  
Vol 21 (4) ◽  
pp. 112-121
Author(s):  
Шин ◽  
Kvok Shin ◽  
Кьёоко ◽  
Okhashi Keoko ◽  
Вэйдон ◽  
...  
Keyword(s):  
Neurological Disorders ◽  
Analytical Methods ◽  
Affective Disorders ◽  
Psychological Symptoms ◽  
Neurological Diseases ◽  
Periodic Limb Movements ◽  
Acute Ischemia ◽  
Behavioural And Psychological Symptoms ◽  
The Brain

. Portable actigraph units allow to long-term of monitoring human cycles and can also be used to quantify the symp-toms of various diseases. The authors studied some applications of actigraphy as analytical methods that are sufficiently sensitive and reliable to determine the severity and consequences of neurological disorders, such as restless legs syndrome, periodic limb movements in sleep, sleep disorders, Parkinson´s disease, depression, behavioural and psychological symptoms in vascular dementia, seasonal affective disorders and acute ischemia of the brain, and the effects of clinical interventions used to treat them. Further research should develop analytical methods to assess other neurological diseases by actigraphic registration.

Moving past the vaccine/autism controversy - to examine potential vaccine neurological harms

2020 ◽  
pp. 1-15
Author(s):  
Peter R. Breggin
Keyword(s):  
Neurological Disorders ◽  
Developmental Disorder ◽  
Physical Symptoms ◽  
Psychosocial Disorders ◽  
The Us ◽  
Potential Vaccine ◽  
Research And Education ◽  
The Brain ◽  
New Vaccines

BACKGROUND: The vaccine/autism controversy has caused vast scientific and public confusion, and it has set back research and education into genuine vaccine-induced neurological disorders. The great strawman of autism has been so emphasized by the vaccine industry that it, and it alone, often appears in authoritative discussions of adverse effects of the MMR and other vaccines. By dismissing the chimerical vaccine/autism controversy, vaccine defenders often dismiss all genuinely neurological aftereffects of the MMR (measles, mumps, and rubella) and other vaccines, including well-documented events, such as relatively rare cases of encephalopathy and encephalitis. OBJECTIVE: This report explains that autism is not a physical or neurological disorder. It is not caused by injury or disease of the brain. It is a developmental disorder that has no physical origins and no physical symptoms. It is extremely unlikely that vaccines are causing autism; but it is extremely likely that they are causing more neurological damage than currently appreciated, some of it resulting in psychosocial disabilities that can be confused with autism and other psychosocial disorders. This confusion between a developmental, psychosocial disorder and a physical neurological disease has played into the hands of interest groups who want to deny that vaccines have any neurological and associated neuropsychiatric effects. METHODS: A review of the scientific literature, textbooks, and related media commentary is integrated with basic clinical knowledge. RESULTS: This report shows how scientific sources have used the vaccine/autism controversy to avoid dealing with genuine neurological risks associated with vaccines and summarizes evidence that vaccines, including the MMR, can cause serious neurological disorders. Manufacturers have been allowed by the US Food and Drug Administration (FDA) to gain vaccine approval without placebo-controlled clinical trials. CONCLUSIONS: The misleading vaccine autism controversy must be set aside in favor of examining actual neurological harms associated with vaccines, including building on existing research that has been ignored. Manufacturers of vaccines must be required to conduct placebo-controlled clinical studies for existing vaccines and for government approval of new vaccines. Many probable or confirmed neurological adverse events occur within a few days or weeks after immunization and could be detected if the trials were sufficiently large. Contrary to current opinion, large, long-term placebo-controlled trials of existing and new vaccines would be relatively easy and safe to conduct.

scholarly journals NeuroRoots, a bio-inspired, seamless Brain Machine Interface device for long-term recording

2018 ◽  
Author(s):  
Marc D. Ferro ◽  
Christopher M. Proctor ◽  
Alexander Gonzalez ◽  
Eric Zhao ◽  
Andrea Slezia ◽  
...  
Keyword(s):  
Neurological Diseases ◽  
Signal Amplitude ◽  
Brain Machine Interface ◽  
Behavioral Experiments ◽  
Adult Rats ◽  
Integrative Level ◽  
Machine Interface ◽  
Freely Moving ◽  
The Brain

AbstractMinimally invasive electrodes of cellular scale that approach a bio-integrative level of neural recording could enable the development of scalable brain machine interfaces that stably interface with the same neural populations over long period of time.In this paper, we designed and created NeuroRoots, a bio-mimetic multi-channel implant sharing similar dimension (10µm wide, 1.5µm thick), mechanical flexibility and spatial distribution as axon bundles in the brain. A simple approach of delivery is reported based on the assembly and controllable immobilization of the electrode onto a 35µm microwire shuttle by using capillarity and surface-tension in aqueous solution. Once implanted into targeted regions of the brain, the microwire was retracted leaving NeuroRoots in the biological tissue with minimal surgical footprint and perturbation of existing neural architectures within the tissue. NeuroRoots was implanted using a platform compatible with commercially available electrophysiology rigs and with measurements of interests in behavioral experiments in adult rats freely moving into maze. We demonstrated that NeuroRoots electrodes reliably detected action potentials for at least 7 weeks and the signal amplitude and shape remained relatively constant during long-term implantation.This research represents a step forward in the direction of developing the next generation of seamless brain-machine interface to study and modulate the activities of specific sub-populations of neurons, and to develop therapies for a plethora of neurological diseases.

scholarly journals Locus Coeruleus Magnetic Resonance Imaging in Neurological Diseases

2020 ◽  
Vol 21 (1) ◽  
Author(s):  
Alessandro Galgani ◽  
Francesco Lombardo ◽  
Daniele Della Latta ◽  
Nicola Martini ◽  
Ubaldo Bonuccelli ◽  
...  
Keyword(s):  
Locus Coeruleus ◽  
Neurological Disorders ◽  
Potential Role ◽  
Neurological Diseases ◽  
Mri Findings ◽  
Promising Tool ◽  
Experimental Tool ◽  
Early Biomarker ◽  
The Brain

Abstract Purpose of Review Locus coeruleus (LC) is the main noradrenergic nucleus of the brain, and its degeneration is considered to be key in the pathogenesis of neurodegenerative diseases. In the last 15 years,MRI has been used to assess LC in vivo, both in healthy subjects and in patients suffering from neurological disorders. In this review, we summarize the main findings of LC-MRI studies, interpreting them in light of preclinical and histopathological data, and discussing its potential role as diagnostic and experimental tool. Recent findings LC-MRI findings were largely in agreement with neuropathological evidences; LC signal showed to be not significantly affected during normal aging and to correlate with cognitive performances. On the contrary, a marked reduction of LC signal was observed in patients suffering from neurodegenerative disorders, with specific features. Summary LC-MRI is a promising tool, which may be used in the future to explore LC pathophysiology as well as an early biomarker for degenerative diseases.

scholarly journals Intranasal Delivery of Nanoformulations: A Potential Way of Treatment for Neurological Disorders

Molecules ◽  
2020 ◽  
Vol 25 (8) ◽  
pp. 1929 ◽  
Author(s):  
Salman Ul Islam ◽  
Adeeb Shehzad ◽  
Muhammad Bilal Ahmed ◽  
Young Sup Lee
Keyword(s):  
Drug Delivery ◽  
Neurological Disorders ◽  
Neurological Diseases ◽  
Nasal Delivery ◽  
Intranasal Route ◽  
Drug Molecules ◽  
Surface Enhanced ◽  
Effective Delivery ◽  
The Central Nervous System ◽  
The Brain

Although the global prevalence of neurological disorders such as Parkinson’s disease, Alzheimer’s disease, glioblastoma, epilepsy, and multiple sclerosis is steadily increasing, effective delivery of drug molecules in therapeutic quantities to the central nervous system (CNS) is still lacking. The blood brain barrier (BBB) is the major obstacle for the entry of drugs into the brain, as it comprises a tight layer of endothelial cells surrounded by astrocyte foot processes that limit drugs’ entry. In recent times, intranasal drug delivery has emerged as a reliable method to bypass the BBB and treat neurological diseases. The intranasal route for drug delivery to the brain with both solution and particulate formulations has been demonstrated repeatedly in preclinical models, including in human trials. The key features determining the efficacy of drug delivery via the intranasal route include delivery to the olfactory area of the nares, a longer retention time at the nasal mucosal surface, enhanced penetration of the drugs through the nasal epithelia, and reduced drug metabolism in the nasal cavity. This review describes important neurological disorders, challenges in drug delivery to the disordered CNS, and new nasal delivery techniques designed to overcome these challenges and facilitate more efficient and targeted drug delivery. The potential for treatment possibilities with intranasal transfer of drugs will increase with the development of more effective formulations and delivery devices.

scholarly journals The Reconnecting the Hand and Arm with Brain (ReHAB) Commentary on “An Integrated Brain-Machine Interface Platform With Thousands of Channels” (Preprint)

2019 ◽  
Author(s):  
Robert F Kirsch ◽  
A Bolu Ajiboye ◽  
Jonathan P Miller
Keyword(s):  
Neurological Disorders ◽  
Brain Machine Interface ◽  
Loss Of Function ◽  
Brain Machine Interfaces ◽  
Electrode Interface ◽  
Machine Interface ◽  
Almost All ◽  
Neuroprosthetic Devices ◽  
The Brain

UNSTRUCTURED Intracortical brain-machine interfaces are a promising technology for allowing people with chronic and severe neurological disorders that resulted in loss of function to potentially regain those functions through neuroprosthetic devices. The penetrating microelectrode arrays used in almost all previous studies of intracortical brain-machine interfaces in people had a limited recording life (potentially due to issues with long-term biocompatibility), as well as a limited number of recording electrodes with limited distribution in the brain. Significant advances are required in this array interface to deal with the issues of long-term biocompatibility and lack of distributed recordings. The Musk and Neuralink manuscript proposes a novel and potentially disruptive approach to advancing the brain-electrode interface technology, with the potential of addressing many of these hurdles. Our commentary addresses the potential advantages of the proposed approach, as well as the remaining challenges to be addressed.

Autophagy & phagocytosis in neurological disorders and their possible cross-talk

2021 ◽  
Vol 19 ◽  
Author(s):  
Gaigai Li ◽  
Prativa Sherchan ◽  
Zhouping Tang ◽  
Jiping Tang
Keyword(s):  
Brain Injury ◽  
Cross Talk ◽  
Neurological Disorders ◽  
Therapeutic Strategy ◽  
Neurological Diseases ◽  
Phagocytic Process ◽  
The Future ◽  
The Brain

: Autophagy and phagocytosis are two important endogenous lysosomal dependent clearing systems in the organism. In some neurological disorders, excessive autophagy or dysfunctional phagocytosis have been shown to contribute to brain injury. Recent studies have revealed that there are underlying interactions between these two processes. However, different studies show inconsistent results for the contribution of autophagy to the phagocytic process in diverse phagocytes and relatively little is known about the link between them especially in the brain. It is critical to understand the role that autophagy plays in phagocytic process in order to promote clearance of endogenous and exogenous detrimental materials. In this review, we highlight studies that focused on phagocytosis and autophagy occurring in the brain and summarized the possible regulatory roles of autophagy in the process of phagocytosis. Balancing the roles of autophagy and phagocytosis may be a promising therapeutic strategy for the treatment of some neurological diseases in the future.

scholarly journals Canadian Association of Neurosciences Review: The Role of Dopamine Receptor Function in Neurodegenerative Diseases

2007 ◽  
Vol 34 (1) ◽  
pp. 18-29 ◽  
Author(s):  
Manon Lebel ◽  
Pierre Robinson ◽  
Michel Cyr
Keyword(s):  
Neurological Disorders ◽  
Molecular Target ◽  
D1 Receptors ◽  
Receptor Function ◽  
Neuronal Toxicity ◽  
Da Receptors ◽  
Canadian Association ◽  
The Brain

Dopamine (DA) receptors, which are heavily expressed in the caudate/putamen of the brain, represent the molecular target of several drugs used in the treatment of various neurological disorders, such as Parkinson's disease. Although most of the drugs are very effective in alleviating the symptoms associated with these conditions, their long-term utilization could lead to the development of severe side-effects. In addition to uncovering novel mediators of physiological DA receptor functions, recent research advances are suggesting a role of these receptors in toxic effects on neurons. For instance, accumulating evidence indicates that DA receptors, particularly D1 receptors, are central in the neuronal toxicity induced by elevated synaptic levels of DA. In this review, we will discuss recent findings on DA receptors as regulators of long term neuronal dysfunction and neurodegenerative processes.

scholarly journals Effects of Neurological Disorders on Bone Health

2020 ◽  
Vol 11 ◽  
Author(s):  
Ryan R. Kelly ◽  
Sara J. Sidles ◽  
Amanda C. LaRue
Keyword(s):  
Bone Health ◽  
Neurological Disorders ◽  
Molecular Mechanisms ◽  
Neurological Diseases ◽  
Sensory Innervation ◽  
Current Evidence ◽  
Bone Homeostasis ◽  
Shared Risk ◽  
The Brain

Neurological diseases, particularly in the context of aging, have serious impacts on quality of life and can negatively affect bone health. The brain-bone axis is critically important for skeletal metabolism, sensory innervation, and endocrine cross-talk between these organs. This review discusses current evidence for the cellular and molecular mechanisms by which various neurological disease categories, including autoimmune, developmental, dementia-related, movement, neuromuscular, stroke, trauma, and psychological, impart changes in bone homeostasis and mass, as well as fracture risk. Likewise, how bone may affect neurological function is discussed. Gaining a better understanding of brain-bone interactions, particularly in patients with underlying neurological disorders, may lead to development of novel therapies and discovery of shared risk factors, as well as highlight the need for broad, whole-health clinical approaches toward treatment.

Sign in / Sign up

Export Citation Format

Share Document