How close I.R. Prigogine, н. наken and S.P. Kurdumov approached to understanding of inevitability of TCS

10.12737/6722 ◽  
2014 ◽  
Vol 3 (3) ◽  
pp. 39-46
Author(s):  
Еськов ◽  
V. Eskov
Keyword(s):  
Systems Approach ◽  
Cellular Level ◽  
Living Systems ◽  
Self Organization ◽  
System State ◽  
The Third ◽  
Physical Chemical ◽  
Novel Approach ◽  
Life Phenomena ◽  
Living Objects

Advances in molecular biology and biophysics (at molecular-cellular level) do not contribute to understanding of life phenomena. Achievements of synergetics (H. Haken) and complexity theory (I. Prigogine) have intensified differences between physical-chemical understandings of life and systemic understandings. In addition to that, the systems approach provides the understanding of effects of living objects and especially its more organized and evolving part – human and humanity. Human-scaled systems possess the unique property – continuous and chaotic movement of many components of a system state vector x= x(t). Taking this property into consideration causes the denial of any known types of stationary nodes (for example, dx/dt=0) and requires reconsideration of concept of chaos. A novel approach for understanding of living systems (as the third paradigm of natural science) and novel methods of studying of living systems (as theory of chaos and self-organization) are proposed by the third paradigm and theory of chaos and self-organization.

An analysis of I.R. Prigogone and J.A. Wheeler’s views concerning emergency of biosystems from the perspective of the third paradigm

10.12737/7652 ◽  
2014 ◽  
Vol 3 (4) ◽  
pp. 47-62 ◽  
Author(s):  
Еськов ◽  
V. Eskov ◽  
Джумагалиева ◽  
L. Dzhumagalieva ◽  
Филатова ◽  
...  
Keyword(s):  
Deterministic Chaos ◽  
Modern Science ◽  
Main Property ◽  
Type Systems ◽  
Distribution Functions ◽  
Living Systems ◽  
Self Organization ◽  
Initial State ◽  
The Third ◽  
Emergent Systems

The main problem of modern science is pointed out: reality of specific three-type systems (TTS) that are usually presented as complexity, and simultaneously impossibility of a description of such systems by a traditional modern reducing approach. Studying properties of system elements cannot help in a description of a complex system itself – complexity (three-type systems, living systems). Hence there arises an acute need in creation of new theories which would operate with maximum uncertainty and unpredictability and provide modeling TTS. The first step in this direction was taken on the grounds of a creation of theory of chaos and self-organization (TCS), according to which complexity cannot repeat an initial state of a system (or a vector parameters x(t0)), measures are not invariant, autocorrelation functions do not converge to zero and Lyapunov exponents are not positive. Chaos of TTS differs from a deterministic chaos and statistical distribution functions f(x) are not appropriate to describe it, because they continuously change. Deterministic, stochastic and chaotic models cannot describe TTS. This is the main property of emergent systems (complexity, TTS), therefore they are described by quasi-attractors.

scholarly journals Prebiotics: A Novel Approach to Treat Hepatocellular Carcinoma

2017 ◽  
Vol 2017 ◽  
pp. 1-11 ◽  
Author(s):  
Naz Fatima ◽  
Tasleem Akhtar ◽  
Nadeem Sheikh
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Cancer ◽  
Antitumor Effect ◽  
Gut Permeability ◽  
Gut Flora ◽  
Effective Barrier ◽  
The Third ◽  
Oncogenic Pathways ◽  
Novel Approach ◽  
Genetic Modifications

Hepatocellular carcinoma is one of the fatal malignancies and is considered as the third leading cause of death. Mutations, genetic modifications, dietary aflatoxins, or impairments in the regulation of oncogenic pathways may bring about liver cancer. An effective barrier against hepatotoxins is offered by gut-liver axis as a change in gut permeability and expanded translocation of lipopolysaccharides triggers the activation of Toll-like receptors which stimulate the process of hepatocarcinogenesis. Prebiotics, nondigestible oligosaccharides, have a pivotal role to play when it comes to inducing an antitumor effect. A healthy gut flora balance is imperative to downregulation of inflammatory cytokines and reducing lipopolysaccharides induced endotoxemia, thus inducing the antitumor effect.

scholarly journals Gastric Cancer Transcription Factors in Patient Reported Outcomes (GCTF-PRO) – Draft proposal

2015 ◽  
Author(s):  
Sonia Lee
Keyword(s):  
Gastric Cancer ◽  
Patient Reported Outcomes ◽  
Statistical Power ◽  
Cellular Level ◽  
Novel Approach ◽  
New Information ◽  
Patient Reported ◽  
Predictive Methods ◽  
Draft Proposal ◽  
Gastric Cancer Patients

The GCTF-PRO seeks to examine the extent gastric cancer patients are tapping into new information particularly outside of conventional healthcare disclosures. Its significance is in assessing dimensions of QOL paradigms that frame statistical power using predictive methods. It seeks to embed evidence-based theories (perceptual and cognitive) to awareness levels in an attempt to bridge the biotechnological advances with prognostic/ diagnostic-related patient satisfactions. At present, it may complement existing GC QOL instruments and offer a novel approach on how cellular level prognoses could possibly correlate with QOL measures.

scholarly journals Production of germ-free mosquitoes via transient colonisation allows stage-specific investigation of host-microbiota interactions

2019 ◽  
Author(s):  
Ottavia Romoli ◽  
Johan Claes Schönbeck ◽  
Siegfried Hapfelmeier ◽  
Mathilde Gendrin
Keyword(s):  
Larval Development ◽  
Emerging Adults ◽  
Larval Instar ◽  
Bacterial Colonisation ◽  
Germ Free ◽  
Functional Studies ◽  
The Third ◽  
Novel Approach ◽  
Folate Biosynthesis ◽  
Vector Borne

AbstractThe mosquito microbiota impacts the physiology of its host and is essential for normal larval development, thereby influencing transmission of vector-borne pathogens. Germ-free mosquitoes generated with current methods show larval stunting and developmental deficits. Therefore, functional studies of the mosquito microbiota have so far mostly been limited to antibiotic treatments of emerging adults. In this study, we developed a novel approach to produce germ-free Aedes aegypti mosquitoes. It is based on reversible colonisation with bacteria genetically modified to allow complete decolonisation at any developmental stage. We show that, unlike germ-free mosquitoes previously produced using sterile diets, reversibly colonised mosquitoes show no developmental retardation and reach the same size as control adults. This allowed us to uncouple the study of the microbiota in larvae and adults. In adults, we detected no impact of bacterial colonisation on mosquito fecundity or longevity. In larvae, we performed a transcriptome analysis and diet supplementation experiments following decolonisation during the third larval instar. Our data suggest that bacteria support larval development by contributing to folate biosynthesis and by enhancing energy storage. Our study establishes a novel tool to study the microbiota in insects and deepens our knowledge on the metabolic contribution of bacteria to mosquito development.

SELF-ORGANIZATION OF FULLERENE C60 MOLECULES IN VOLUME OF EVAPORATING DROPLETS

2018 ◽  
Vol 20 (5) ◽  
pp. 309-314
Author(s):  
U.K. Makhmanov ◽  
A.M. Kokhkharov ◽  
S.A. Bakhramov
Keyword(s):  
Room Temperature ◽  
Ostwald Ripening ◽  
Substrate Surface ◽  
Fullerene C60 ◽  
Chemical Mechanism ◽  
Self Organization ◽  
Flat Substrate ◽  
Large Structures ◽  
Physical Chemical ◽  
Two Component

An efficient method of formation of the ordered fullerene C60 nanoaggregates in the volume of evaporating fullerene droplets in mixtures of two-component solvents (benzene and acetonitrile) on a flat substrate surface at room temperature is demonstrated. The specific physical-chemical mechanism of the synthesis of fullerene C60 aggregates in the volume of the evaporating droplet of solution, so called Ostwald ripening, according to which relatively large structures grow at the expense of smaller ones, has been proposed.

Constructive Molecular Dynamics Lattice Gases: Three-Dimensional Molecular Self-Assembly

2003 ◽  
Author(s):  
Martin Nilsson ◽  
Steen Rasmussen
Keyword(s):  
Molecular Dynamics ◽  
Self Assembly ◽  
Lattice Gas ◽  
Chemical Properties ◽  
Special Kind ◽  
Lattice Gases ◽  
Living Systems ◽  
Self Organization ◽  
Assembly Systems ◽  
Formal Systems

Realistic molecular dynamics and self-assembly is represented in a lattice simulation where water, water-hydrocarbons, and water-amphiphilic systems are investigated. The details of the phase separation dynamics and the constructive self-assembly dynamics are discussed and compared to the corresponding experimental systems. The method used to represent the different molecular types can easily be expended to include additional molecules and thus allow the assembly of more complex structures. This molecular dynamics (MD) lattice gas fills a modeling gap between traditional MD and lattice gas methods. Both molecular objects and force fields are represented by propagating information particles and all microscopic interactions are reversible. Living systems, perhaps the ultimate constructive dynamical systems, is the motivation for this work and our focus is a study of the dynamics of molecular self-assembly and self-organization. In living systems, matter is organized such that it spontaneously constructs intricate functionalities at all levels from the molecules up to the organism and beyond. At the lower levels of description, chemical reactions, molecular selfassembly and self-organization are the drivers of this complexity. We shall, in this chapter, demonstrate how molecular self-assembly and selforganization processes can be represented in formal systems. The formal systems are to be denned as a special kind of lattice gas and they are in a form where an obvious correspondence exists between the observables in the lattice gases and the experimentally observed properties in the molecular self-assembly systems. This has the clear advantage that by using these formal systems, theory, simulation, and experiment can be conducted in concert and can mutually support each other. However, a disadvantage also exists because analytical results are difficult to obtain for these formal systems due to their inherent complexity dictated by their necessary realism. The key to novelt simpler molecules (from lower levels), dynamical hierarchies are formed [2, 3]. Dynamical hierarchies are characterized by distinct observable functionalities at multiple levels of description. Since these higher-order structures are generated spontaneously due to the physico-chemical properties of their building blocks, complexity can come for free in molecular self-assembly systems. Through such processes, matter apparently can program itself into structures that constitute living systems [11, 27, 30].

Sign in / Sign up

Export Citation Format

Share Document