scholarly journals PERITUMORAL EDEMA AT BRAIN MENINGIOMAS

2016 ◽  
Vol 1 (1) ◽  
pp. 7-11
Author(s):  
Борисов ◽  
Eduard Borisov ◽  
Сороковиков ◽  
Vladimir Sorokovikov ◽  
Бывальцев ◽  
...  
Keyword(s):  
Brain Edema ◽  
Tumor Tissue ◽  
Neural System ◽  
Peritumoral Edema ◽  
Olfactory Groove ◽  
Peritumoral Brain Edema ◽  
Patient Localization ◽  
High Degree ◽  
Slow Growing ◽  
Obvious Relation

Among edema-producing neoplasms of central neural system, the meningiomas are unique. Meningiomas are histologically benign, slow growing and originate extracerebrally. The development of accompanying peritumoral brain edema (PВE) occurs in 40–60 % of meningiomas and often with a high degree of PВE with no obvious relation to the size and histologic features of the meningioma. The aim of our study was to determine the correlation between such parameters as gender, age of the patient, localization of the tumor tissue and the presence/severity of PBE. At meningiomas PBE was present in 70,1 % of patients. Meningioma with the presence of PBE occur more often than tumors without PBE. Olfactory groove tumors have more pronounced degree of PBE, unlike meningiomas of parasagittal localization and the region of the wings of the sphenoid bone. Mixed meningiomas had a greater degree of PBE unlike meningotheliomatozic and fibroblastic variants.

scholarly journals P.035 Peritumoral brain edema in meningiomas: correlation with surgical findings and prognosis

2018 ◽  
Vol 45 (s2) ◽  
pp. S25-S25
Author(s):  
AM Seleem ◽  
AA Farag
Keyword(s):  
Brain Edema ◽  
Postoperative Morbidity ◽  
Interface Plane ◽  
Peritumoral Edema ◽  
Negative Group ◽  
Positive Group ◽  
Postoperative Prognosis ◽  
Peritumoral Brain Edema ◽  
Case Mortality ◽  
Operative Monitoring

Background: Peritumoral brain edema(PTBE) in meningiomas had been a subject of interest; its occurrence in an extra-axial tumor was the reason of many studies and published data.Our study was made to evaluate the exact implication of Peritumoral brain edema in meningiomas in intraoperative and short postoperative prognosis. Methods: During 2006 to 2011,45 patients with supratentorial meningiomas were studied.Intraoperatively,certain findings were reported including: easy or difficult resection,Simpson’s grade of removal,brain tumor interface,plane of cleavage, pial vascularization of the tumor and arachnoid disruption.Morbidity and mortality were recorded;also postoperative CT and/or MRI were obtained within the first 3 months. Results: There were 26 meningiomas (57.7%) with peritumoral edema and 19 meningiomas without (42.3%).Pial vascularization of the tumor was defined in 24 patients (53.3%),four patients(21%) had a pial blood supply in edema negative group compared to 20 patients (76.9%) in edema positive group. In this study, there was one case mortality (2.2%) in edema positive group.As regard morbidity, eight (30.6%) patients in edema positive group suffered an early postoperative morbidity this is in comparison to four patients(21%) in the edema negative group. Conclusions: Our study shows that PTBE in meningiomas affects the surgical prognosis and confers a higher risk of morbidity and postoperative complications.Preoperative management of PTBE and immediate post-operative monitoring are important.

scholarly journals Peritumoral brain edema in intracranial meningiomas

2010 ◽  
Vol 68 (3) ◽  
pp. 346-349 ◽  
Author(s):  
Nelson de Azambuja Pereira-Filho ◽  
Fabiano Pasqualotto Soares ◽  
Ivan de Mello Chemale ◽  
Ligia Maria Barbosa Coutinho
Keyword(s):  
Brain Edema ◽  
Pathophysiological Mechanism ◽  
Histological Subtype ◽  
Porto Alegre ◽  
Olfactory Groove ◽  
Intracranial Meningiomas ◽  
Peritumoral Brain Edema

Occurrence of peritumoral brain edema (PBE) in meningiomas has been associated with several factors in recent years, although its pathophysiological mechanism has not yet been fully elucidated. The aim of this study was to analyze the correlation between the presence / degree of PBE and factors such as gender, age, size and histological subtype of tumor. We analyzed the MRI images of 74 patients operated on Hospital Beneficência Portuguesa de Porto Alegre for the presence / degree of PBE and data was statistically correlated with the parameters of the patient. PBE was present in 70.1% of patients. Tumors with higher volume had more PBE. Tumors of the olfactory groove showed more PBE than sphenoid wing and parassagittal tumors. Transitional subtype showed more PBE than fibroblastic and meningothelial subtypes.

scholarly journals The importance of pial blood supply to the development of peritumoral brain edema in meningiomas

1997 ◽  
Vol 2 (4) ◽  
pp. E6 ◽  
Author(s):  
Michael Bitzer ◽  
Lars Wöckel ◽  
Andreas R. Luft ◽  
Ajay K. Wakhloo ◽  
Dirk Petersen ◽  
...  
Keyword(s):  
Brain Edema ◽  
Blood Supply ◽  
Tumor Size ◽  
Tumor Volume ◽  
Volume Ratio ◽  
Total Tumor Volume ◽  
Pial Vessels ◽  
Peritumoral Brain Edema ◽  
Tumor Region ◽  
The Mean

The authors studied the pial and dural blood supplies in 74 intracranial meningiomas and quantified their associated peritumoral brain edema (PTBE). The extent and localization of pial blush in relation to the total tumor volume were determined angiographically. The amount of edema and tumor size were calculated using computerized tomography. The edema-tumor volume ratio was defined as Edema Index (EI). There were 49 meningiomas with PTBE; of those tumors, 46 were supplied by pial vessels, and three were supplied exclusively by dural vessels. Tumors without PTBE showed no pial blush. The mean EI in meningiomas with pial blush was significantly larger (EI = 3.0) than in meningiomas without pial supply (EI = 1.1; p < 0.0001). Meningiomas in which 10% of the whole tumor volume was supplied by pial vessels had only a small mean EI of 2.2, whereas tumors with pial blood supply greater than or equal to 20% had a mean EI of 3.3 (p < 0.026). In 69.9% of cases with pial blood supply, major portions of the edema were located adjacent to the tumor region supplied by pial vessels. Edema index differences among tumors of different subgroups, as defined by size or histology, were significantly related to the pial supply in each subset. Thus, pial blood supply may be causative for the development of PTBE in meningiomas.

scholarly journals Peritumoral brain edema associated with meningioma

Cancer ◽  
1999 ◽  
Vol 85 (4) ◽  
pp. 936-944 ◽  
Author(s):  
Hiroyuki Yoshioka ◽  
Seiji Hama ◽  
Eiji Taniguchi ◽  
Kazuhiko Sugiyama ◽  
Kazunori Arita ◽  
...  
Keyword(s):  
Brain Edema ◽  
Peritumoral Brain Edema

Peritumoral brain edema in angiomatous supratentorial meningiomas: an investigation of the vascular endothelial growth factor A pathway

Apmis ◽  
2013 ◽  
Vol 121 (11) ◽  
pp. 1025-1036 ◽  
Author(s):  
Damoun Nassehi ◽  
Lars P. Sørensen ◽  
Henrik Dyrbye ◽  
Carsten Thomsen ◽  
Marianne Juhler ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Brain Edema ◽  
Vascular Endothelial ◽  
Peritumoral Brain Edema ◽  
Endothelial Growth Factor

Role of hydrodynamic processes in the pathogenesis of peritumoral brain edema in meningiomas

2000 ◽  
Vol 93 (4) ◽  
pp. 594-604 ◽  
Author(s):  
Michael Bitzer ◽  
Thomas Nägele ◽  
Beverly Geist-Barth ◽  
Uwe Klose ◽  
Eckardt Grönewäller ◽  
...  
Keyword(s):  
Contrast Agent ◽  
Brain Edema ◽  
Brain Tissue ◽  
Magnetic Resonance Images ◽  
Content Type ◽  
Extracellular Contrast Agent ◽  
Peritumoral Brain Edema ◽  
Hydrodynamic Processes ◽  
Fine Print

Object. In a prospective study, 28 patients with 32 intracranial meningiomas were examined to determine the role of hydrodynamic interaction between tumor and surrounding brain tissue in the pathogenesis of peritumoral brain edema.Methods. Gadolinium—diethylenetriamine pentaacetic acid (Gd-DPTA), an extracellular contrast agent used for routine clinical imaging, remains strictly extracellular without crossing an intact blood—brain barrier. Therefore, it is well suited for investigations of hydrodynamic extracellular mechanisms in the development of brain edema. Spin-echo T1-weighted magnetic resonance images were acquired before and after intravenous administration of 0.2 mmol/kg Gd-DPTA. Additional T1-weighted imaging was performed 0.6, 3.5, and 6.5 hours later. No significant Gd-DPTA diffused from tumor into peritumoral brain tissue in 12 meningiomas without surrounding brain edema. In contrast, in 17 of 20 meningiomas with surrounding edema, contrast agent in peritumoral brain tissue was detectable after 3.5 hours and 6.5 hours. In three of 20 meningiomas with minimum surrounding edema (< 5 cm3), contrast agent effusion was absent. After 3.5 hours and 6.5 hours strong correlations of edema volume and the maximum distance of contrast spread from the tumor margin into adjacent brain parenchyma (r = 0.84 and r = 0.87, respectively, p < 0.0001) indicated faster effusion in larger areas of edema.Conclusions. The results of this study show that significant contrast agent effusion from the extracellular space of the tumor into the interstitium of the peritumoral brain tissue is only found in meningiomas with surrounding edema. This supports the hypothesis that hydrodynamic processes play an essential role in the pathogenesis of peritumoral brain edema in meningiomas.

scholarly journals High Delta-Like Ligand 4 (DLL4) Is Correlated With Peritumoral Brain Edema and Predicts Poor Prognosis in Primary Glioblastoma

Medicine ◽  
2014 ◽  
Vol 93 (8) ◽  
pp. e57 ◽  
Author(s):  
Xian-xin Qiu ◽  
Long Chen ◽  
Chen-hong Wang ◽  
Zhi-xiong Lin ◽  
Chang-fu Zhou ◽  
...  
Keyword(s):  
Brain Edema ◽  
Poor Prognosis ◽  
Primary Glioblastoma ◽  
Peritumoral Brain Edema

Predictive Factors of Postoperative Peritumoral Brain Edema after Meningioma Resection

2021 ◽  
Vol 69 (6) ◽  
pp. 1682
Author(s):  
Jian Gong ◽  
Liang-Ming Li ◽  
Wen-Jian Zheng ◽  
Ying-Zhi Chen ◽  
Zi-Hui Hu ◽  
...  
Keyword(s):  
Brain Edema ◽  
Predictive Factors ◽  
Peritumoral Brain Edema

Prostaglandins F2α and E2 as Possible Mediators of Peritumoral Brain Edema

1988 ◽  
pp. 243-249 ◽  
Author(s):  
J. Anagnostopoulos-Schleep ◽  
W. Schlegel ◽  
K. H. Krähling ◽  
H.-J. König
Keyword(s):  
Brain Edema ◽  
Peritumoral Brain Edema
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