The Effects of Individual Vitamin and Mineral Complex on Some Parameters of Physical Capacity and Blood Oxidative Metabolism in Athletes

2015 ◽  
Vol 22 (4) ◽  
pp. 127-131
Author(s):  
Мартусевич ◽  
A. Martusevich ◽  
Карузин ◽  
K. Karuzin
Keyword(s):  
Superoxide Dismutase ◽  
Antioxidant Capacity ◽  
Oxidative Metabolism ◽  
Total Antioxidant Capacity ◽  
Physical Capacity ◽  
Mineral Complex ◽  
Total Antioxidant ◽  
Oxidative Processes ◽  
The Individual ◽  
Positive Effect

The purpose of this work was the estimation of the effects of the individual technology of metabolic correction on the parameters of the physical capacity and blood oxidative processes in athletes. The authors studied physical capacity indexes and blood oxidative metabolism (by total antioxidant capacity and activity of superoxide dismutase) in 24 athletes of main group (with vitamin and mineral complex) and 30 sportsmen, which got a placebo. It was stated the positive effect of investigated complex on the physical capacity, is realized through the directed optimization of the blood oxidative metabolism, first of all – antioxidant enzymes.

scholarly journals Decreased Superoxide Dismutase Concentrations (SOD) in Plasma and CSF and Increased Circulating Total Antioxidant Capacity (TAC) Are Associated with Unfavorable Neurological Outcome after Aneurysmal Subarachnoid Hemorrhage

2021 ◽  
Vol 10 (6) ◽  
pp. 1188
Author(s):  
Harald Krenzlin ◽  
Dominik Wesp ◽  
Jan Schmitt ◽  
Christina Frenz ◽  
Elena Kurz ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Superoxide Dismutase ◽  
Subarachnoid Hemorrhage ◽  
Brain Injury ◽  
Antioxidant Capacity ◽  
Neurological Outcome ◽  
Total Antioxidant Capacity ◽  
Early Brain Injury ◽  
Fisher Grade ◽  
Total Antioxidant

Background: Subarachnoid hemorrhage (SAH) is a devastating disease with high morbidity and mortality. Hypoxia-induced changes and hemoglobin accumulation within the subarachnoid space are thought to lead to oxidative stress, early brain injury, and delayed vasospasm. This study aimed to evaluate the antioxidant status and its impact on neurological outcome in patients with aneurysmal SAH. Methods: In this prospective observational study, 29 patients with aneurysmal SAH were included (mean age 54.7 ± 12.4). Blood and cerebrospinal fluid (CSF) samples were collected on days (d) 1, 3, and 7. In addition, 29 patients without intracranial hemorrhage served as controls. The antioxidant system was analyzed by glutathione peroxidase (GSH-Px; U/L) and total and free glutathione-sulfhydryl (GSH; mg/L) in the plasma. Superoxide dismutase (SOD, U/mL) and total antioxidant capacity (TAC, µmol/L) were measured in the serum and CSF. Clinical data were compiled on admission (Hunt and Hess grade, Fisher grade, and GCS). Neurological and cognitive outcome (modified Rankin scale (mRS), Glasgow Outcome Scale Extended (GOSE) and Montreal Cognitive Assessment (MoCA)) was assessed after 6 weeks (6 w) and 6 months (6 m). Results: Plasma levels of SOD increased from day 1 to 7 after SAH (d1: 1.22 ± 0.36 U/L; d3: 1.25 ± 0.33 U/L, p = 0.99; d7: 1.52 ± 0.4 U/L, p = 0.019) and were significantly higher compared to controls (1.11 ± 0.27 U/L) at day 7 (p < 0.001). Concordantly, CSF levels of SOD increased from day 1 to 7 after SAH (d1: 1.22 ± 0.41 U/L; d3: 1.77 ± 0.73 U/L, p = 0.10; d7: 2.37 ± 1.29 U/L, p < 0.0001) without becoming significantly different compared to controls (1.74 ± 0.8 U/L, p = 0.09). Mean plasma TAC at day 1 (d1: 77.87 ± 49.72 µmol/L) was not statistically different compared to controls (46.74 ± 32.42 µmol/L, p = 0.25). TAC remained unchanged from day 1 to 7 (d3: 92.64 ± 68.58 µmol/L, p = 0.86; d7: 74.07 ± 54.95 µmol/L, p = 0.8) in plasma. TAC in CSF steeply declined from day 1 to 7 in patients with SAH becoming significantly different from controls at days 3 and 7 (d3: 177.3 ± 108.7 µmol/L, p = 0.0046; d7: 85.35 ± 103.9 µmol/L, p < 0.0001). Decreased SOD levels in plasma and CSF are associated with a worse neurological outcome 6 weeks (mRS: CSF p = 0.0001; plasma p = 0.027/GOSE: CSF p = 0.001; plasma p = 0.001) and 6 months (mRS: CSF p = 0.001; plasma p = 0.09/GOSE: CSF p = 0.001; plasma p = 0.001) after SAH. Increased plasma TAC correlated with a worse neurological outcome 6 weeks (mRS: p = 0.001/GOSE p = 0.001) and 6 months (mRS p = 0.001/GOSE p = 0.001) after SAH. Conclusion: In our study, a reduction in the antioxidative enzyme SOD and elevated TAC were associated with a poorer neurological outcome reflected by mRS and GOSE at 6 weeks and 6 months after SAH. A lower initial SOD CSF concentration was associated with the late deterioration of cognitive ability. These findings support the mounting evidence of the role of oxidative stress in early brain injury formation and unfavorable outcome after SAH.

Total Antioxidant Capacity of Blood Plasma from Healthy Donors Receiving Vitamin and Mineral Complex

2004 ◽  
Vol 137 (5) ◽  
pp. 457-459 ◽  
Author(s):  
M. V. Voronin ◽  
E. S. Sidneva ◽  
T. A. Lisitsyna ◽  
A. K. Zhanataev ◽  
A. D. Durnev
Keyword(s):  
Blood Plasma ◽  
Antioxidant Capacity ◽  
Total Antioxidant Capacity ◽  
Mineral Complex ◽  
Healthy Donors ◽  
Total Antioxidant

scholarly journals Antioxidative responses to seasonal changes and chemiluminescence assay of Astragalus onobrychis leaves extract

2013 ◽  
Vol 11 (2) ◽  
pp. 123-132
Author(s):  
Dragoljub Miladinović ◽  
Budimir Ilić ◽  
Stevo Najman ◽  
Olga Cvetković ◽  
Aleksandra Šajnović ◽  
...  
Keyword(s):  
Superoxide Dismutase ◽  
Enzyme Activity ◽  
Glutathione Peroxidase ◽  
Antioxidant Capacity ◽  
Total Antioxidant Capacity ◽  
Seasonal Changes ◽  
Antioxidant Enzyme Activity ◽  
Guaiacol Peroxidase ◽  
Stages Of Growth ◽  
Total Antioxidant

AbstractThe aim of this study was to research the seasonal changes of antioxidant enzyme activity and total antioxidant capacity in leaves of Astragalus onobrychis L. subsp. chlorocarpus (Griseb.) S. Kozuharov et D.K. Pavlova. Leaves of A. onobrychis were collected during the different stages of growth and analyzed for antioxidant enzyme activity: superoxide dismutase, catalase, guaiacol peroxidase, glutathione peroxidase. Quantities of malonyldialdehyde, superoxide radicals, and hydroxyl radicals were measured as well as the content of soluble proteins. Furthermore, total antioxidant capacity was determined by the inhibition of chemiluminescence activity of blood phagocytes by leaf extracts. Stages of vegetation significantly affected the accumulation of superoxide radicals, but there were no significant differences in hydroxyl radical quantity and lipid peroxidation levels during vegetation. Soluble proteins vary greatly between different stages of growth. Seasonal changes were found to have an effect on enzymatic activities. During the spring season, guaiacol peroxidase showed the highest levels. Catalase and glutathione peroxidase increased their activities in summer, while, during the autumn season, superoxide dismutase showed maximum activity. On the basis of chemiluminescence assay, it can be concluded that leaf extract of A. onobrychis possesses a significant antioxidant capacity thus protecting plants during environmental stress.

scholarly journals Plasma Total Antioxidant Capacity and Activities of Blood Glutathione Peroxidase and Superoxide Dismutase Determined in Healthy Dogs by Using Commercially Available Kits

2016 ◽  
Vol 66 (4) ◽  
pp. 534-548 ◽  
Author(s):  
Katerina Tomsič ◽  
Alenka Seliškar ◽  
Barbara Lukanc ◽  
Alenka Nemec Svete
Keyword(s):  
Superoxide Dismutase ◽  
Glutathione Peroxidase ◽  
Antioxidant Capacity ◽  
Total Antioxidant Capacity ◽  
Significant Difference ◽  
Erythrocyte Superoxide Dismutase ◽  
Total Antioxidant ◽  
Antioxidant Parameters ◽  
Healthy Dogs ◽  
Effect Of Age

AbstractData on the values of selected blood antioxidant parameters, i.e. total antioxidant capacity, glutathione peroxidase, and superoxide dismutase in healthy dogs, are lacking. There are no published accepted standard reference methods for their determination. The aim of this study was to determine the values of plasma total antioxidant capacity and the activities of whole blood glutathione peroxidase and erythrocyte superoxide dismutase in 30 healthy client-owned dogs (19 females, 11 males). The effect of age and sex on the measured antioxidant parameters was also investigated. Antioxidant parameters were determined with an automated biochemical analyser, using the commercially available Randox kits. No significant difference in age, weight, and antioxidant parameters was determined between females and males. A significant positive effect of age (p = 0.002, r2= 0.284) on superoxide dismutase activity was confirmed. There was no effect of sex on any of the antioxidant parameters measured. However, we observed a tendency of the effect of sex (p = 0.063, r2= 0.118), as well as age (p = 0.073, r2= 0.111), on the activity of glutathione peroxidase. Our results are in part comparable with the results of other studies in which the same types of methods and samples were used to determine antioxidant parameters. In conclusion, the sex and age of dogs should be taken into consideration when planning a study on antioxidant status parameters.

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