Patho-morphological changes of tissue of hypervascular formation at the endovascular treatment

2015 ◽  
Vol 9 (1) ◽  
pp. 0-0
Author(s):  
Ольшанский ◽  
M. Olshanskiy ◽  
Харитонов ◽  
D. Kharitonov ◽  
Степанов ◽  
...  
Keyword(s):  
Blood Flow ◽  
Multidisciplinary Approach ◽  
Morphological Changes ◽  
Endovascular Embolization ◽  
Ischemic Necrosis ◽  
Inflammatory Infiltration ◽  
Cavernous Malformations ◽  
Tissue Ischemia ◽  
Surgical Treatments ◽  
Further Development

Treatment of hypervascular formations is challenging surgery. The solution of this problem is due to use a multidisciplinary approach, involving complex endovascular and surgical treatments. Patho-morphological study of remote hypervascular formations in treatment was carried out. That treatment consisted of an endovascular embolotherapy and an endovasal sclerotherapy in various combinations. The embolization of blood vessels leads to a complete reduction of blood flow in the formation area, the development of diffuse inflammatory infiltration in the background on tissue ischemia. In the future, developing ischemic necrosis fol-lowed by scarring of tissue surrounding the vascular formation. Sclerotherapy causes damage to the vascular endothelium with fibrin formation and hemolysis of red blood cells in the lumen of the veins. Moreover, there are a significant fibrosis, hyalinosis and inflammatory reaction of the tissues surrounding the vessels. Further development of this process leads to a final sclerosis and fibrotic scarring of the surrounding tissues. The combi-nation of endovascular embolization and sclerotherapy allows to achieve a reduction of blood flow in the arterial vascular malformation department and to cause a tissue fibrosis in the cavernous malformations. Endovascular therapy reduces the risk of bleeding in surgery and develops the capacity of radical treatment.

scholarly journals The clinically relevant diabetic foot syndrome morphology

2021 ◽  
Vol 11 (5) ◽  
pp. 262-274
Author(s):  
V. Polyovyy ◽  
Bilel Khorshani ◽  
R. Sydorchuk ◽  
P. Kyfiak ◽  
O. Khomko ◽  
...  
Keyword(s):  
Diabetic Foot ◽  
Morphological Changes ◽  
Cellular Level ◽  
Molecular Structures ◽  
Diabetic Foot Syndrome ◽  
Inflammatory Infiltration ◽  
Diffuse Infiltration ◽  
Tissue Ischemia ◽  
Tissue Edema ◽  
The Status

Objective: to evaluate the morphological changes in diabetic foot syndrome emphasizing the ultrastructural cellular changes.Material and methods. Biopsies of the chronic lesions in 120 diabetic foot patients following necessary preparatory stages were studied by histological, histochemical and electron microscopy methods.Results. The inflammatory infiltration and destruction and involving all layers of skin and soft tissue, the phenomena of vacuolation, apoptosis or karyolysis; tissue edema, diffuse infiltration by neutrophils, vascular plethora with stasis, thrombosis, and necrosis were observed. Microcirculatory tract thrombosis exacerbated tissue ischemia, contributing to the progression of pathology. The macrophages' cytoplasm characterized by the presence of phagocytosed and digested microorganisms often intact inside them. The changes in the status of nuclear and perinuclear material were accompanied by compression and dehydration of the cell, which ended in its fragmentation and the formation of tightly contacting bodies of various shapesConclusions. Morphological changes in diabetic foot syndrome are diverse and uneven, occurring not only on tissue and cellular level but involves subcellular and molecular structures, encouraging further research in this field. Foci of destruction and lysis of the newly formed epithelium are characteristic for diabetic foot, which is not observed in the normal wound process.

Importance of airway blood flow on particle clearance from the lung

1996 ◽  
Vol 81 (5) ◽  
pp. 1878-1883 ◽  
Author(s):  
Elizabeth M. Wagner ◽  
W. Michael Foster
Keyword(s):  
Blood Flow ◽  
Autologous Blood ◽  
Left Lung ◽  
Mucosal Blood Flow ◽  
Control Flow ◽  
Time Data ◽  
Tissue Ischemia ◽  
Bronchial Circulation ◽  
Insoluble Particles ◽  
Particle Clearance

Wagner, Elizabeth M., and W. Michael Foster. Importance of airway blood flow on particle clearance from the lung. J. Appl. Physiol. 81(5): 1878–1883, 1996.—The role of the airway circulation in supporting mucociliary function has been essentially unstudied. We evaluated the airway clearance of inert, insoluble particles in anesthetized ventilated sheep ( n = 8), in which bronchial perfusion was controlled, to determine whether airway mucosal blood flow is essential for maintaining surface transport of particles through airways. The bronchial branch of the bronchoesophageal artery was cannulated and perfused with autologous blood at control flow (0.6 ml ⋅ min−1⋅ kg−1) or perfusion was stopped. With the sheep in a supine position and after a steady-state133Xe ventilation scan for designation of lung zones of interest, an inert99mTc-labeled sulfur colloid aerosol (2.1-μm diameter) was deposited in the lung. The clearance kinetics of the radiolabeled particles were determined from the activity-time data obtained for right and left lung zones. At 60 min postdeposition of aerosol, average airway particle retention for control bronchial blood flow conditions was 57 ± 7 (SE)% for the right and 53 ± 8% for the left lung zones. Clearance of particles was significantly impaired when bronchial blood flow was stopped, e.g., right and left lung zones averaged 77 ± 6 and 76 ± 7% at 60 min, respectively ( P < 0.05). These data demonstrate a significant influence of the bronchial circulation on mucociliary transport of insoluble particles. Potential mechanisms that may account for these results include the importance of the bronchial circulation for nutrient flow, maintenance of airway wall temperature and humidity, and release of mediators and sequelae associated with tissue ischemia.

Effects of Cytoflavin and Neuronol on Morphological Changes in the Brain and Survival of Rats with Ischemic Disturbances in Cerebral Blood Flow

2004 ◽  
Vol 137 (4) ◽  
pp. 411-414 ◽  
Author(s):  
V. V. Bulon ◽  
I. B. Krylova ◽  
N. R. Evdokimova ◽  
A. L. Kovalenko ◽  
L. E. Alekseeva ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Morphological Changes ◽  
The Brain

scholarly journals Non-surgical treatments of complications after dental implantation. Perspectives for infrared laser light in the treatment of mucositis and peri-implantitis

2020 ◽  
Vol 24 (1) ◽  
pp. 49-56
Author(s):  
I. N. Razina ◽  
L. M. Lomiashvili ◽  
V. B. Nedoseko
Keyword(s):  
Laser Light ◽  
Antimicrobial Effect ◽  
Infrared Region ◽  
Surface Cleaning ◽  
Electromagnetic Spectrum ◽  
Implant Surface ◽  
Dental Implantation ◽  
Surgical Treatments ◽  
Further Development ◽  
Inflammatory Effect

The present article is a review of literature sources and electronic databases on the conservative treatment of mucositis and peri-implantitis. The authors analyze potentials of diode lasers, generating light in the infrared region of electromagnetic spectrum. They discuss further development of this direction and issues for the application of this type of lasers in implantology. They also discuss several parameters for the discussed laser light in dental implantology, like: antimicrobial effect, thermal effect, possible damage to implant surface, biostimulating and anti-inflammatory effect, better implant surface cleaning, accelerated osseointegration, control for apical migration and formation of stable denture attachment.

scholarly journals Characterisation of Morphology in Musculus Semitendinosus Tendon Used for Anterior Cruciate Ligament Reconstruction: A Pilot Study

2020 ◽  
Vol 18 (1) ◽  
pp. 1-6
Author(s):  
Janis Davis Osipovs ◽  
Mara Pilmane ◽  
Modris Ciems
Keyword(s):  
Anterior Cruciate Ligament ◽  
Morphological Changes ◽  
Cruciate Ligament ◽  
Collagen I ◽  
Collagen Fibres ◽  
Nerve Fibres ◽  
Tissue Ischemia ◽  
Moderate Number ◽  
Collagen Iii ◽  
Anterior Cruciate

SummaryIntroductionAnterior cruciate ligament (ACL) rupture is very common in athletes. In the general population, incidence is approximately 33 per 100 000 people.Aim of the studyThe aim of the study was the evaluation of morphological changes in the musculus semitendinosus tendon used for the reconstruction of ACL to understand the quality of most common for surgery used material.Material and methodsThe materials were obtained from four ACL autologous hamstring reconstruction surgeries. The tissue was stained with hematoxyllin and eosin and with immunohistochemical (IMH) staining of PGP9.5, VEGF, collagen I and collagen III. The material was evaluated with semiquantitative method.ResultsRoutine staining showed practically unchanged tendon structure, with one exception when sclerotic blood vessels were observed in endotenon. Collagen III IMH demonstrated moderate to numerous positive collagen fibres in two cases, but in other two there were only few positive structures seen. Collagen I IMH showed few to moderate number of positive collagen fibres in all cases. In two cases, moderate number of PGP9.5 positive nerve fibres was observed and in two other cases occasional to few number of positive structures was detected. PGP 9.5 marked higher number of nerve fibres in peritenon than in endotenon. Numerous VEGF positive endotheliocytes were observed in two cases, but in two other cases VEGF positive endotheliocytes were occasional.ConclusionsTendon of musculus semitendinosus displays two patterns of distribution of tissue ischemia, neuropeptide containing innervation and collagen I and III. Collagen III is thought to be evaluated as a response of tendon to the ischemia and intensive innervation, while increase of collagen I probably is related to the relatively unchanged vascularity and innervation. The pattern of musculus semitendinosus tendon structural changes seems to be connected to the individual homeostasis in patients persisting before the usage of tendon for the reconstruction.

scholarly journals ANGIOPULMONOGRAPHY WITH NITROGLYCERIN TEST IN THE DIAGNOSIS OF ACUTE INFECTIOUS LUNG DESTRUCTION

2021 ◽  
Vol 29 (4) ◽  
pp. 412-419
Author(s):  
V.I. Petukhov ◽  
◽  
V.I. Derkach ◽  
S.N. Ermashkevich ◽  
M.V. Kuntsevich ◽  
...  
Keyword(s):  
Blood Flow ◽  
Differential Diagnosis ◽  
Test Performance ◽  
Blood Circulation ◽  
Lung Parenchyma ◽  
Inflammatory Infiltration ◽  
Affected Area ◽  
Vascular Bed ◽  
Pulmonary Parenchyma ◽  
Flow Through

Objective. To develop a method for additional and differential diagnosis of acute infectious lung destruction (AILD) based on angiopulmonography with the nitroglycerin test. Methods. Angiopulmonography with the nitroglycerin test was used in 10 patients with suppurative diseasesof thelung and pleura for additional and differential diagnosis of AILD The method was used in such situations when chest computed tomography did not allow to determine unambiguously the presence and / or prevalence of necrosis of the lung parenchyma. Results. In 3 patients with the lung abscess, a clear restriction of the decay cavity was registered with the preservation of the main blood flow and weakening of the parenchymal phase of the blood circulation along the periphery of the destructive area. During the nitroglycerin test performance there was no change in the filling of the microvascular bed with contrast along the periphery of the decay cavity, which made it possible to determine the presence of parietal sequesters. According to the results of the study, the lung gangrene was diagnosed in 6 patients. At the same time, two variants of circulatory disorders were noted: the first - with preservation of the blood flow through the main vessels and with the absence of a parenchymal phase in the lesion focus, the second - with the violation of the main blood flow. In the affected area no change in blood flow was observed after the nitroglycerin test performance. Similar results of the study indicated the development of necrosis of the pulmonary parenchyma, which was subsequently confirmed during the operations performed. In the site of inflammatory infiltration of the pulmonary parenchyma with preserved main blood flow, the depletion of the parenchymal phase of blood circulation was determined, but after the nitroglycerin test, a pronounced enrichment of the vascular architecture to the parenchymal phase in the pneumonia affecting part of the lung was noted. Conclusion. It has been established that AILD is characterized by irreversible changes in the vascular bed of the lung parenchyma in the lesion focus. Angiopulmonography with the nitroglycerin test is considered to be an additional highly informative method improving the early and differential diagnosis of AILD in difficult clinical situations. What this paper adds It has been found out that during angiopulmonography the areas of pulmonary necrosis are characterized by the absence of a vascular pattern with or without disturbance of the blood flow through the segmental arteries. At the same time, in contrast to the foci of pneumonia, the nitroglycerin test is not accompanied by an evaluation of the filling of the pulmonary vascular bed in the affected area, i.e. blood supply disorders are irreversible. Thus, based on an assessment of the nature and reversibility of the blood flow disturbances in the affected lung, it is possible to carry out differential diagnosis of the early stages of acute infectious lung destruction (AILD) and pneumonia.

scholarly journals Multitarget, Selective Compound Design Yields Picomolar Inhibitors of a Kinetoplastid Pteridine Reductase 1

2020 ◽  
Author(s):  
Ina Poehner ◽  
Antonio Quotadamo ◽  
Joanna Panecka-Hofman ◽  
Rosaria Luciani ◽  
Matteo Santucci ◽  
...  
Keyword(s):  
Drug Discovery ◽  
Dihydrofolate Reductase ◽  
Multidisciplinary Approach ◽  
Microwave Assisted Synthesis ◽  
Crystallographic Structure ◽  
Computational Docking ◽  
Design And Optimization ◽  
Microwave Assisted ◽  
Structure Activity ◽  
Further Development

The optimization of compounds with multiple targets in the drug discovery cycle is a difficult multidimensional problem. Here, we present a systematic, multidisciplinary approach to the development of selective anti-parasitic compounds. Efficient microwave-assisted synthesis of pteridines along with iterations of crystallographic structure determination were used to validate computational docking predictions and support derivation of a structure-activity relationship for multitarget inhibition. This approach yielded compounds showing picomolar inhibition of <i>T. brucei</i> pteridine reductase 1 (PTR1), nanomolar inhibition of <i>L. major</i> PTR1, along with selective submicromolar inhibition of parasitic dihydrofolate reductase (DHFR). Moreover, by combining design for polypharmacology with a property-based on-parasite optimization, we found three compounds that exhibited micromolar EC<sub>50</sub> values against <i>T. brucei brucei</i>, whilst retaining their target inhibition. Our results provide a basis for the further development of pteridine-based compounds and we expect our multitarget approach to be generally applicable to the design and optimization of anti-infective agents.<br>

scholarly journals Multitarget, Selective Compound Design Yields Picomolar Inhibitors of a Kinetoplastid Pteridine Reductase 1

2020 ◽  
Author(s):  
Ina Poehner ◽  
Antonio Quotadamo ◽  
Joanna Panecka-Hofman ◽  
Rosaria Luciani ◽  
Matteo Santucci ◽  
...  
Keyword(s):  
Drug Discovery ◽  
Dihydrofolate Reductase ◽  
Multidisciplinary Approach ◽  
Microwave Assisted Synthesis ◽  
Crystallographic Structure ◽  
Computational Docking ◽  
Design And Optimization ◽  
Microwave Assisted ◽  
Structure Activity ◽  
Further Development

The optimization of compounds with multiple targets in the drug discovery cycle is a difficult multidimensional problem. Here, we present a systematic, multidisciplinary approach to the development of selective anti-parasitic compounds. Efficient microwave-assisted synthesis of pteridines along with iterations of crystallographic structure determination were used to validate computational docking predictions and support derivation of a structure-activity relationship for multitarget inhibition. This approach yielded compounds showing picomolar inhibition of <i>T. brucei</i> pteridine reductase 1 (PTR1), nanomolar inhibition of <i>L. major</i> PTR1, along with selective submicromolar inhibition of parasitic dihydrofolate reductase (DHFR). Moreover, by combining design for polypharmacology with a property-based on-parasite optimization, we found three compounds that exhibited micromolar EC<sub>50</sub> values against <i>T. brucei brucei</i>, whilst retaining their target inhibition. Our results provide a basis for the further development of pteridine-based compounds and we expect our multitarget approach to be generally applicable to the design and optimization of anti-infective agents.<br>

scholarly journals A rare case report on double J stenting in a rare case antepartum patient with right sided hydronephrosis and hydroureter

2021 ◽  
Vol 10 (10) ◽  
pp. 3989
Author(s):  
Niranjan N. Chavan ◽  
Shikhanshi . ◽  
Tulika Chouhan ◽  
Shreya Kampoowale
Keyword(s):  
Rare Case ◽  
Multidisciplinary Approach ◽  
Renal Colic ◽  
Symptom Relief ◽  
Severe Form ◽  
Gravid Uterus ◽  
Potential Harm ◽  
Rare Case Report ◽  
Loin Pain ◽  
Surgical Treatments

Gestational hydronephrosis (GH) is caused due to dilatation effect of the progesterone as well as physical pressure of the gravid uterus. In pregnancy, its management is challenging as routine radiological investigations and surgical treatments cannot be performed due to the potential harm to the foetus. Women who fail to respond to conservative methods require intervention. Acute hydronephrosis and renal colic are common aetiologies for loin pain, and can lead to severe form of urinary tract infection affecting perinatal outcome. Double J (DJ) stenting during pregnancy is safe, requiring no intra-operative imaging, and inserted under local anaesthesia. It provides good symptom relief, low complication rate, efficient and safe modality for women with refractory symptoms. Multidisciplinary approach to this procedure is advised.

scholarly journals A Single-Connector Stent Antenna for Intravascular Monitoring Applications

Sensors ◽  
2019 ◽  
Vol 19 (21) ◽  
pp. 4616 ◽  
Author(s):  
Liu ◽  
Chen ◽  
Hsiao
Keyword(s):  
Blood Pressure ◽  
Blood Flow ◽  
Wireless Communications ◽  
Flow Velocity ◽  
Blood Flow Velocity ◽  
Electrical Current ◽  
Biomedical Signals ◽  
External Monitoring ◽  
Intravascular Stents ◽  
Further Development

Recently, smart stents have been developed by integrating various sensors with intravascular stents for detecting vascular restenosis or monitoring intravascular biomedical conditions such as blood pressure or blood flow velocity. The information on biomedical signals is then transmitted to external monitoring systems via wireless communications. Due to the limited volumes of blood vessels and limited influence of blood flow, antennas with good radiation performance are required for intravascular applications. In this paper, we propose a stent antenna composed of multiple rings containing crowns and struts, where each ring is connected with one connector. Unlike a conventional stent, wherein each ring is connected with several connectors, the single connector prevents the random distribution of electrical current and thus achieves good radiation performance. The implantable stent antenna is designed for the frequency range of 2 to 3 GHz for minimum penetration loss in the human body and tissues. Mechanical FEM simulations were conducted to ensure that the mechanical deformation was within specific limits during balloon expansions. A prototype was fabricated with laser cutting techniques and its radiation performance experimentally characterized. It was demonstrated that the fabricated stent antenna had an omnidirectional radiation pattern for arbitrary receiving angles, a gain of 1.38 dBi, and a radiation efficiency of 74.5% at a resonant frequency of 2.07 GHz. The main contribution of this work was the manipulation of the current distributions of the stent for good EM radiation performances which needed to be further examined while inserted inside human bodies. These research results should contribute to the further development of implantable wireless communications and intravascular monitoring of biomedical signals such as blood pressure and blood flow velocity.

Sign in / Sign up

Export Citation Format

Share Document