scholarly journals Gastric Emptying of a Carbohydrate-electrolyte Solution in Healthy Volunteers Depends on Osmotically Active Particles

2013 ◽  
Vol 80 (5) ◽  
pp. 342-349 ◽  
Author(s):  
Chol Kim ◽  
Tadashi Okabe ◽  
Minoru Sakurai ◽  
Koji Kanaya ◽  
Keiichi Ishihara ◽  
...  
Keyword(s):  
Gastric Emptying ◽  
Healthy Volunteers ◽  
Electrolyte Solution ◽  
Active Particles

A study of gastric emptying in H. pylori negative healthy volunteers using the 13C-octanoic acid breath test

2000 ◽  
Vol 118 (4) ◽  
pp. A1169 ◽  
Author(s):  
Shigeyuki Ebara ◽  
Nobuo Aoyama ◽  
Toshiyuki Sakai ◽  
Takahiro Ikemura ◽  
Daisuke Shirasaka ◽  
...  
Keyword(s):  
Gastric Emptying ◽  
Healthy Volunteers ◽  
Breath Test ◽  
Octanoic Acid ◽  
H Pylori

Su2071 The Effect of the Bitter Taste Receptor Agonist Denatonium Benzoate on Gastric Emptying, Satiety and Return of Hunger After a Meal in Healthy Volunteers

2013 ◽  
Vol 144 (5) ◽  
pp. S-548 ◽  
Author(s):  
Sofie Verschueren ◽  
Pieter Janssen ◽  
Christopher N. Andrews ◽  
Kristin Verbeke ◽  
Inge Depoortere ◽  
...  
Keyword(s):  
Gastric Emptying ◽  
Healthy Volunteers ◽  
Receptor Agonist ◽  
Bitter Taste ◽  
Taste Receptor ◽  
Bitter Taste Receptor ◽  
Denatonium Benzoate

Dual effects of cisapride on gastric emptying and antropyloroduodenal motility

1993 ◽  
Vol 264 (2) ◽  
pp. G195-G201 ◽  
Author(s):  
R. Fraser ◽  
M. Horowitz ◽  
A. Maddox ◽  
J. Dent
Keyword(s):  
Gastric Emptying ◽  
Healthy Volunteers ◽  
Gastric Motility ◽  
Normal Subjects ◽  
Solid Component ◽  
Pressure Waves ◽  
Dual Effect ◽  
Intravenous Saline ◽  
Plausible Mechanism ◽  
Stimulation Of

There is little information about the effects of cisapride on human antropyloroduodenal motility, despite its documented efficacy for increasing the rate of gastric emptying in patients with gastroparesis. Cisapride has been reported to have little effect on gastric emptying in normal subjects. Antral, pyloric, and duodenal pressures were recorded simultaneously with gastric emptying in 20 healthy volunteers. Thirty minutes after the solid component of the meal had started to empty from the stomach, each subject received either 10 mg cisapride i.v. (11 subjects) or intravenous saline (9 subjects). Intravenous saline had no effect on either motility or gastric emptying. In contrast, cisapride administration was associated with a dual effect on motility, with initial suppression of antral pressure waves (P < 0.05) followed by stimulation of associated antropyloroduodenal pressure waves (P < 0.01). Gastric emptying slowed in the first 30 min after cisapride (P < 0.05), and this was followed by more rapid gastric emptying (P < 0.01). The amount of the meal emptied in the 60 min after cisapride correlated with the number of associated antroduodenal pressure waves (r = 0.75, P < 0.001) but not with the number of antral waves (r = 0.42, NS). These results indicate that cisapride in a dose of 10 mg i.v. has dual effects on gastric emptying and gastric motility. The stimulation of associated antral pressure waves is a plausible mechanism for the efficacy of cisapride in the treatment of gastroparesis.

Effect of intragastric barostat bag on proximal and distal gastric accommodation in response to liquid meal

2002 ◽  
Vol 283 (3) ◽  
pp. G681-G686 ◽  
Author(s):  
M. W. Mundt ◽  
T. Hausken ◽  
M. Samsom
Keyword(s):  
Gastric Emptying ◽  
Healthy Volunteers ◽  
Gold Standard ◽  
Gastric Volume ◽  
Gastric Accommodation ◽  
Liquid Meal ◽  
Transpyloric Flow ◽  
Antral Area

The barostat is the gold standard for measurement of proximal gastric accommodation. Ultrasonography can be used to measure gastric volume. The aim was to investigate the effects of the barostat bag on gastric accommodation and transpyloric flow. Accommodation after a liquid meal (300 ml, 450 kcal) was measured twice at random in eight healthy volunteers. Proximal accommodation was measured once using barostat and once using ultrasound (US). Antrum accommodation was measured using US. Bag volume (BV), antral area (AA), proximal gastric area, and proximal gastric diameter (PGD) data were assessed before and 1, 5, 15, 30, 40, 50, and 60 min postprandially. Transpyloric flow was measured using Doppler 1–5 min postprandially. Fasted, AA size was not affected by the barostat bag (1 mmHg > minimal distension pressure; 2.7 ± 0.5 vs. 2.6 ± 0.3 cm2). Postprandially, AAs were larger with the bag present (ANOVA, P < 0.04). Maximum AA was reached with the bag in 5 min, without the bag in 1 min postprandially (15.1 ± 2.3 vs. 9.4 ± 1.5 cm2; P < 0.03). Furthermore, AAs were related to BVs ( r = 0.57; P < 0.01). After bag deflation, AA decreased (11.9 ± 1.8 to 7.0 ± 0.9 cm2; P = 0.02) and was comparable with the 60-min AA size without the bag (7.1 ± 1.2 cm2; P = 0.76) present. Proximal gastric radius calculated from the BVs and PGDs was larger with the bag present (ANOVA, P < 0.001). No effect on early gastric emptying was observed. Postprandially, the barostat bag causes dilatation of the antrum due to meal displacement without influencing early gastric emptying. This antral dilatation is likely to induce exaggerated proximal gastric relaxation observed in studies using the barostat to evaluate fundic accommodation.

235 PF-04548043, a Novel Motilin Receptor Agonist, Increases Gastric Emptying in Healthy Volunteers and Does Not Undergo Tachyphylaxis

2009 ◽  
Vol 136 (5) ◽  
pp. A-45 ◽  
Author(s):  
Jeremy D. Gale ◽  
Peter J. Colman ◽  
Constantino Kantaridis ◽  
Catherine Claes ◽  
Radu Tutuian
Keyword(s):  
Gastric Emptying ◽  
Healthy Volunteers ◽  
Receptor Agonist ◽  
Motilin Receptor
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