scholarly journals Inducible Nitric Oxide Synthase Participates in Cochlear Damage after Acoustic Stimulation in Guinea Pigs

2012 ◽  
Vol 79 (2) ◽  
pp. 121-128 ◽  
Author(s):  
Shunta Inai ◽  
Ken-ichi Watanabe ◽  
Kimihiro Okubo
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Inducible Nitric Oxide Synthase ◽  
Guinea Pigs ◽  
Acoustic Stimulation ◽  
Cochlear Damage ◽  
Oxide Synthase ◽  
Inducible Nitric Oxide

Expression of inducible nitric oxide synthase (iNOS/NOS II) in the hydropic cochlea of guinea pigs

2000 ◽  
Vol 143 (1-2) ◽  
pp. 23-28 ◽  
Author(s):  
Olaf Michel ◽  
Alexander Hess ◽  
Jiping Su ◽  
Wilhelm Bloch ◽  
Eberhard Stennert ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Inducible Nitric Oxide Synthase ◽  
Guinea Pigs ◽  
Oxide Synthase ◽  
Inducible Nitric Oxide

Expression of inducible nitric oxide synthase (iNOS/NOS II) in the hydropic vestibule after injection of keyhole limpet hemocyanin into the endolymphatic sac of guinea pigs

2001 ◽  
Vol 11 (2) ◽  
pp. 67-71
Author(s):  
Ken-ichi Watanabe ◽  
Shunichi Tomiyama ◽  
Ken Jinnouchi ◽  
Alexander Hess ◽  
Olaf Michel ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Inducible Nitric Oxide Synthase ◽  
Guinea Pigs ◽  
Endolymphatic Hydrops ◽  
Keyhole Limpet Hemocyanin ◽  
Endolymphatic Sac ◽  
Temporal Bones ◽  
Oxide Synthase ◽  
Inducible Nitric Oxide

This study was undertaken to examine the expression of inducible nitric oxide synthase (iNOS / NOS II) in the hydropic vestibule of guinea pigs. Animals were systemically sensitized with 500 μg of keyhole limpet hemocyanin. Two weeks after the first injection, keyhole limpet hemocyanin (100 μg/5 μl) was injected into the endolymphatic sac following the intradural approach, and the next day temporal bones were removed for the immunohistochemical examination. Endolymphatic hydrops was evidenced by the expansion of the Reissner's membrane in the cochlea after direct injection of keyhole limpet hemocyanin into the endolymphatic sac. Inducible nitric oxide synthase expression was increased in the sensory cells, supporting cells and vestibular ganglion cells, while temporal bones, where only phosphate buffered saline was injected, did not show any inducible nitric oxide synthase immunoreactivity. High levels of inducible nitric oxide synthase-catalyzed nitric oxide were detected prior to the development of the inner ear dysfunction. Our results suggest that the occurrence of inducible nitric oxide synthase immunoreactivity parallels the inner ear disturbance as seen in endolymphatic hydrops.

Dose-dependent attenuation of lipopolysaccharide-fever by inhibitors of inducible nitric oxide-synthase in guinea pigs

1999 ◽  
Vol 383 (2) ◽  
pp. 177-187 ◽  
Author(s):  
Joachim Roth ◽  
Birgit Störr ◽  
Jörg-Michael Goldbach ◽  
Karlheinz Voigt ◽  
Eugen Zeisberger
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Inducible Nitric Oxide Synthase ◽  
Guinea Pigs ◽  
Oxide Synthase ◽  
Dose Dependent ◽  
Inducible Nitric Oxide

Expression of inducible nitric oxide synthase (iNOS/NOS II) in the cochlea of guinea pigs after intratympanical endotoxin-treatment

1999 ◽  
Vol 830 (1) ◽  
pp. 113-122 ◽  
Author(s):  
Alexander Hess ◽  
Wilhelm Bloch ◽  
Jochen Huverstuhl ◽  
Jiping Su ◽  
Eberhard Stennert ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Inducible Nitric Oxide Synthase ◽  
Guinea Pigs ◽  
Oxide Synthase ◽  
Inducible Nitric Oxide

Expression of Inducible Nitric Oxide Synthase in the Cochlea following Immune Response in the Endolymphatic Sac of Guinea Pigs

ORL ◽  
2001 ◽  
Vol 63 (3) ◽  
pp. 155-159 ◽  
Author(s):  
Ken-ichi Watanabe ◽  
Shunichi Tomiyama ◽  
Ken Jinnouchi ◽  
Ruby Pawankar ◽  
Toshiaki Yagi
Keyword(s):  
Nitric Oxide ◽  
Immune Response ◽  
Nitric Oxide Synthase ◽  
Inducible Nitric Oxide Synthase ◽  
Guinea Pigs ◽  
Endolymphatic Sac ◽  
Oxide Synthase ◽  
Inducible Nitric Oxide
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