scholarly journals Biological activity of optically active salithion and salioxon.

1989 ◽  
Vol 53 (1) ◽  
pp. 175-178 ◽  
Author(s):  
Akinori HIRASHIMA ◽  
Isaac ISHAAYA ◽  
Ryohei UENO ◽  
Yoshifumi ICHIYAMA ◽  
Shao-Yong WU ◽  
...  
Keyword(s):  
Biological Activity ◽  
Optically Active

scholarly journals Synthesis of Optically Active Bicyclic Derivatives of Nitroimidazoles

Compounds ◽  
2021 ◽  
Vol 1 (3) ◽  
pp. 145-153
Author(s):  
Justyna Żwawiak ◽  
Lucjusz Zaprutko
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Biological Activity ◽  
Optically Active ◽  
Tuberculostatic Activity ◽  
Wide Range ◽  
Derivatives Of

Nitroimidazoles are characterized by a wide range of biological activity and many of them are used as therapeutics. Moreover, some bicyclic nitroimidazooxazoles show considerable potency against Mycobacterium tuberculosis. Some authors noticed that in the case of chiral derivatives of nitroimidazodihydrooxazoles, the (R) form shows a greater tuberculostatic activity than the (S) enantiomer. This work describes the procurement of new 12 enantiomeric bicyclic derivatives of nitroimidazole.

Synthesis and Antifungal Activity of New Dihydropyrazoles of Designed Curcumin Analogues

2019 ◽  
Vol 4 (2) ◽  
pp. 94-100
Author(s):  
Vishwa Deepak Tripathi ◽  
Nisha Saxena
Keyword(s):  
Biological Activity ◽  
Minimum Inhibitory Concentration ◽  
Phenyl Ring ◽  
Mass Spectra ◽  
Inhibitory Concentration ◽  
Pyrazole Ring ◽  
Optically Active ◽  
1H And 13C Nmr ◽  
Curcumin Analogues ◽  
Antifungal Potential

A library of new dihydropyrazole derivatives have been synthesized from well designed curcumin analogues by reaction of chalcone derivatives with phenylhydrazine. All the synthesized compounds were characterized by spectroscopic (1H and 13C NMR, IR spectra), spectrometric (Mass spectra) data and elemental analysis. Dihydro-pyrazoles exhibited characteristic dd (double doublet) due to presence of optically active carbon of pyrazole ring. All the synthesized compounds were also evaluated for their antifungal potential against six different fungal starins. Evaluated heterocyles showed potent inhibitory property against tested fungal strains with minimum inhibitory concentration (MIC) values upto 3.12 μg/mL. Heterocyles with nitro and methoxy substitutions were showing best antifungal activities. Among 20 different derivatives tested for biological activity SAR has been developed between the various substitutions at phenyl ring of synthesized heterocycles.

scholarly journals Asymmetric Synthesis of Tetrasubstituted α-Aminophosphonic Acid Derivatives

Molecules ◽  
2021 ◽  
Vol 26 (11) ◽  
pp. 3202
Author(s):  
Aitor Maestro ◽  
Xabier del Corte ◽  
Adrián López-Francés ◽  
Edorta Martínez de Marigorta ◽  
Francisco Palacios ◽  
...  
Keyword(s):  
Amino Acids ◽  
Biological Activity ◽  
Absolute Configuration ◽  
Strong Dependence ◽  
Structural Similarity ◽  
Optically Active ◽  
Biologically Active ◽  
Chiral Molecules ◽  
Aminophosphonic Acid ◽  
The Past

Due to their structural similarity with natural α-amino acids, α-aminophosphonic acid derivatives are known biologically active molecules. In view of the relevance of tetrasubstituted carbons in nature and medicine and the strong dependence of the biological activity of chiral molecules into their absolute configuration, the synthesis of α-aminophosphonates bearing tetrasubstituted carbons in an asymmetric fashion has grown in interest in the past few decades. In the following lines, the existing literatures for the synthesis of optically active tetrasubstituted α-aminophosphonates are summarized, comprising diastereoselective and enantioselective approaches.

Biological Activity of Optically Active Salithion and Salioxon

1989 ◽  
Vol 53 (1) ◽  
pp. 175-178 ◽  
Author(s):  
Akinori Hirashima ◽  
Isaac Ishaaya ◽  
Ryohei Ueno ◽  
Yoshifumi Ichiyama ◽  
Shao-Yong Wu ◽  
...  
Keyword(s):  
Biological Activity ◽  
Optically Active

ChemInform Abstract: Optically Active Juvenoids Derived from 2-Substituted Cyclopentanol and Their Biological Activity on Tenebrio molitor.

ChemInform ◽  
2010 ◽  
Vol 30 (13) ◽  
pp. no-no
Author(s):  
Martin Rejzek ◽  
Zdenek Wimmer ◽  
Marie Zarevucka ◽  
Jelena Kuldova ◽  
David Saman ◽  
...  
Keyword(s):  
Biological Activity ◽  
Tenebrio Molitor ◽  
Optically Active

scholarly journals Der Einfluß von Atropisomerie und chiralem Zentrum auf die biologische Aktivität des Metolachlor / The Influence of Atropisomerism and Chiral Centre on the Biological Activity of Metolachlor

1982 ◽  
Vol 37 (4) ◽  
pp. 451-462 ◽  
Author(s):  
Hans Moser ◽  
Grety Rihs ◽  
Hanspeter Sauter
Keyword(s):  
Biological Activity ◽  
Optically Active ◽  
Herbicidal Activity ◽  
X Ray ◽  
Biologische Aktivität ◽  
Herbicide Metolachlor

The four stereoisomers of the grass herbicide Metolachlor, the isomerism of which is based on a combination of a chiral centre and a chiral axis, were prepared, and their absolute configurations determined by X-ray analysis. The synthesis was achieved by using optically active starting materials and new optically active carbamates as intermediates. The herbicidal activity is mainly influenced by the chiral centre, the S-isomers being the most active ones.

scholarly journals STUDY OF BIOLOGICAL ACTIVITY OF RACEMIC AND OPTICALLY ACTIVE ESTERS OF NAPHTHENIC AND FATTY ACIDS BASED ON UNSATURATED OXYESTERS

2021 ◽  
pp. 42-58
Author(s):  
A.N. Bagirli ◽  
Keyword(s):  
Fatty Acids ◽  
Biological Activity ◽  
Naphthenic Acids ◽  
Optically Active ◽  
Active Esters ◽  
Aromatic Esters ◽  
Antimicrobial And Antifungal Activity ◽  
Escherichia Coli Bacteria ◽  
Allyl Esters ◽  
Test Cultures

Petrochemical products based on petroleum naphthenic acids have special properties. Esters of naphthenic acids possess practically valuable organic compounds. The aim of this work is the development of effective methods for the preparation of aromatic esters based on naphthenic and individual fatty acids which is a very promising direction in the medicine practice. The synthesis of unsaturated racemic and chiral oxyethers was carried out on the basis of the interaction of chloromethylpropargyl (allyl) esters with carbonyl compounds with the participation of metallic zinc. Also, to study the biological activity, racemic and optically active esters were synthesized based on naphthenic acids and unsaturated racemic and chiral oxyesters. As test cultures used: gram-positive (Staphylo-coccus aureus-Staphylococcus aureus), gram-negative (Pseudomonas aeruginosa – Pseu-domonas aeruginosa, Escherichia coli) bacteria, as well as yeast-like fungi of the genus Candida - Candida albicans. Analysis of the biological activity of the synthesized compounds showed that optically active bicyclo [2.2.1] hept-5-ene-2-methylol monoesters have higher antimicrobial and antifungal activity compared to their racemic analogs and drugs used in medicine.

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