Synthesis, absolute stereochemistry, and biological activity of optically active cyclodiene insecticides

1978 ◽  
Vol 26 (4) ◽  
pp. 975-977 ◽  
Author(s):  
Akio Miyazaki ◽  
Tokuji Hotta ◽  
Shingo Marumo ◽  
Michihiko Sakai
Keyword(s):  
Biological Activity ◽  
Optically Active ◽  
Cyclodiene Insecticides ◽  
Absolute Stereochemistry

scholarly journals Isolation and Absolute Stereochemistry of Optically Active Sydonic Acid fromGloniumsp. (Hysteriales, Ascomycota)

2009 ◽  
Vol 73 (1) ◽  
pp. 203-204 ◽  
Author(s):  
Shinji KUDO ◽  
Takanori MURAKAMI ◽  
Junsuke MIYANISHI ◽  
Kazuaki TANAKA ◽  
Noboru TAKADA ◽  
...  
Keyword(s):  
Optically Active ◽  
Absolute Stereochemistry

scholarly journals Biological activity of optically active salithion and salioxon.

1989 ◽  
Vol 53 (1) ◽  
pp. 175-178 ◽  
Author(s):  
Akinori HIRASHIMA ◽  
Isaac ISHAAYA ◽  
Ryohei UENO ◽  
Yoshifumi ICHIYAMA ◽  
Shao-Yong WU ◽  
...  
Keyword(s):  
Biological Activity ◽  
Optically Active

scholarly journals Synthesis of Optically Active Bicyclic Derivatives of Nitroimidazoles

Compounds ◽  
2021 ◽  
Vol 1 (3) ◽  
pp. 145-153
Author(s):  
Justyna Żwawiak ◽  
Lucjusz Zaprutko
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Biological Activity ◽  
Optically Active ◽  
Tuberculostatic Activity ◽  
Wide Range ◽  
Derivatives Of

Nitroimidazoles are characterized by a wide range of biological activity and many of them are used as therapeutics. Moreover, some bicyclic nitroimidazooxazoles show considerable potency against Mycobacterium tuberculosis. Some authors noticed that in the case of chiral derivatives of nitroimidazodihydrooxazoles, the (R) form shows a greater tuberculostatic activity than the (S) enantiomer. This work describes the procurement of new 12 enantiomeric bicyclic derivatives of nitroimidazole.

Synthesis and Antifungal Activity of New Dihydropyrazoles of Designed Curcumin Analogues

2019 ◽  
Vol 4 (2) ◽  
pp. 94-100
Author(s):  
Vishwa Deepak Tripathi ◽  
Nisha Saxena
Keyword(s):  
Biological Activity ◽  
Minimum Inhibitory Concentration ◽  
Phenyl Ring ◽  
Mass Spectra ◽  
Inhibitory Concentration ◽  
Pyrazole Ring ◽  
Optically Active ◽  
1H And 13C Nmr ◽  
Curcumin Analogues ◽  
Antifungal Potential

A library of new dihydropyrazole derivatives have been synthesized from well designed curcumin analogues by reaction of chalcone derivatives with phenylhydrazine. All the synthesized compounds were characterized by spectroscopic (1H and 13C NMR, IR spectra), spectrometric (Mass spectra) data and elemental analysis. Dihydro-pyrazoles exhibited characteristic dd (double doublet) due to presence of optically active carbon of pyrazole ring. All the synthesized compounds were also evaluated for their antifungal potential against six different fungal starins. Evaluated heterocyles showed potent inhibitory property against tested fungal strains with minimum inhibitory concentration (MIC) values upto 3.12 μg/mL. Heterocyles with nitro and methoxy substitutions were showing best antifungal activities. Among 20 different derivatives tested for biological activity SAR has been developed between the various substitutions at phenyl ring of synthesized heterocycles.

scholarly journals Asymmetric Synthesis of Tetrasubstituted α-Aminophosphonic Acid Derivatives

Molecules ◽  
2021 ◽  
Vol 26 (11) ◽  
pp. 3202
Author(s):  
Aitor Maestro ◽  
Xabier del Corte ◽  
Adrián López-Francés ◽  
Edorta Martínez de Marigorta ◽  
Francisco Palacios ◽  
...  
Keyword(s):  
Amino Acids ◽  
Biological Activity ◽  
Absolute Configuration ◽  
Strong Dependence ◽  
Structural Similarity ◽  
Optically Active ◽  
Biologically Active ◽  
Chiral Molecules ◽  
Aminophosphonic Acid ◽  
The Past

Due to their structural similarity with natural α-amino acids, α-aminophosphonic acid derivatives are known biologically active molecules. In view of the relevance of tetrasubstituted carbons in nature and medicine and the strong dependence of the biological activity of chiral molecules into their absolute configuration, the synthesis of α-aminophosphonates bearing tetrasubstituted carbons in an asymmetric fashion has grown in interest in the past few decades. In the following lines, the existing literatures for the synthesis of optically active tetrasubstituted α-aminophosphonates are summarized, comprising diastereoselective and enantioselective approaches.

Antioestrogenic and antifertility compounds. III. Enantiomers of (±)-hexoestrol and its homologues

1970 ◽  
Vol 23 (8) ◽  
pp. 1605 ◽  
Author(s):  
DJ Collins ◽  
JJ Hobbs
Keyword(s):  
Butyric Acid ◽  
Active Site ◽  
Oestrogen Receptor ◽  
Optically Active ◽  
Valeric Acid ◽  
Absolute Stereochemistry

(�)-2,3-Bis(p-hydroxyphenyl)butane (5a) and (&)-3,4-bis(p-hydroxyphenyl)-hexane (5c) were resolved, and absolute stereochemistry of the former was established as (-)-(2R,3R) by correlation with (+)-(R)-2,3-bis(p-methoxyphenyl)but-1-en. The (+) and (-) isomers of erythro-2,3-bis(p-hydroxyphenyl)pentane (Sb) were synthesized from (-)- and (+)-erythro-2,3-bis(p-methoxyphenyl)valeric acid, respectively. (+)-erythro-2,3-Bis(p-hydroxyphenyl)pentane (5b) was shown to have the (2R,3S) configuration, and (+)-threo-(b) the (2S,3S) configuration, by correlation with (-)-(8)-2,3-bis(p-methoxyphenyl)pent-1-ene. It follows that the configuration of erythro-2,3-bis(p-methoxyphenyl)-valeric and the corresponding-butyric acid is (+)-(2S,3R). Interaction of optically active hexoestrol and its homologues with the oestrogen receptor active site is discussed in terms of steroid stereochemistry.

Biological Activity of Optically Active Salithion and Salioxon

1989 ◽  
Vol 53 (1) ◽  
pp. 175-178 ◽  
Author(s):  
Akinori Hirashima ◽  
Isaac Ishaaya ◽  
Ryohei Ueno ◽  
Yoshifumi Ichiyama ◽  
Shao-Yong Wu ◽  
...  
Keyword(s):  
Biological Activity ◽  
Optically Active
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