scholarly journals Liver lipid accumulation and fatty acid flux in rats fed a low protein diet containing purified whole egg protein.

1977 ◽  
Vol 41 (1) ◽  
pp. 43-48
Author(s):  
Kazumi YAGASAKI ◽  
Masao KAMETAKA
Keyword(s):  
Fatty Acid ◽  
Lipid Accumulation ◽  
Liver Lipid ◽  
Protein Diet ◽  
Low Protein Diet ◽  
Low Protein ◽  
Egg Protein ◽  
Whole Egg

Discrimination by Rhesus Monkeys of Diets Containing Supplemental Amino Acids

1975 ◽  
Vol 41 (3) ◽  
pp. 683-689
Author(s):  
Samuel N. Craddock ◽  
Arthur J. Riopelle
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Rhesus Monkeys ◽  
Normal Diet ◽  
Protein Diet ◽  
Low Protein Diet ◽  
Low Protein ◽  
Egg Protein ◽  
Protein Diets ◽  
Whole Egg

Following an opportunity to demonstrate a preference for water with or without the addition of the amino acid isoleucine, methionine, phenylalanine, or tryptophan at a concentration proportional to that in whole egg protein, 9 monkeys were subjected on 4 occasions to a 7-day experimental week when they received an isocaloric diet containing only one-fourth the amount of protein of their normal diet. An identical low-protein diet supplemented with one of the above amino acids, again at a concentration proportional to that in egg, was presented for an equivalent period during the experimental week and the amounts consumed of each diet were compared. Ss failed to exhibit a preference or an aversion for water supplemented with any of the amino acids; however, all low-protein diets supplemented with an amino acid were consumed in greater quantities than a low-protein diet lacking a supplement. On Days 6 and 7 of the experimental weeks when protein depletion was most severe, Ss significantly ( p < .05) preferred the diet supplemented with isoleucine to a diet lacking the supplement.

Low-protein diet during gestation and lactation increases hepatic lipid accumulation through autophagy and histone deacetylase

2020 ◽  
Vol 319 (1) ◽  
pp. E11-E25
Author(s):  
Huan Wang ◽  
Guanying Bianca Xu ◽  
Diego Hernández-Saavedra ◽  
Hong Chen ◽  
Yuan-Xiang Pan
Keyword(s):  
Amino Acid ◽  
Histone Deacetylase ◽  
Lipid Accumulation ◽  
Protein Diet ◽  
Low Protein Diet ◽  
Low Density ◽  
Hepatic Lipid ◽  
Low Protein ◽  
Triglyceride Accumulation ◽  
Autophagic Degradation

The present study examined the mechanism of a low-protein (LP) diet on hepatic lipid metabolism during gestation and lactation. Timed-pregnant Sprague-Dawley rats were fed a control or an LP diet during gestation and lactation. LP dams had increased hepatic triglyceride accumulation and a significantly higher aspartate/alanine transaminase ratio, accompanied by a decrease in the circulating very low-density/low-density lipoprotein ratio. Microtubule-associated protein 1 light-chain 3β (LC3B) expression was stimulated in LP dams along with increased histone acetylation. LP diet induced colocalization of the LC3 binding motif interacting proteins apolipoprotein B (APOB) or microsomal triglyceride transfer protein (MTTP) with LC3B, suggesting autophagic degradation. Histone deacetylase 3 (HDAC3) is found necessary to prevent lipid accumulation in response to amino acid deprivation in HepG2 cells. LC3B-mediated APOB protein degradation is related to increases in lipid accumulation. HDAC3 regulated LC3B-induced lipid accumulation potentially through autophagic degradation of APOB and MTTP in response to amino acid limitation caused by a low-protein diet.

FP384EFFECT OF OMEGA-3 FATTY ACID AND MENAQUINONE-7 ON OSTEOPENIA AND SARCOPENIA IN ADENINE AND LOW PROTEIN DIET INDUCED UREMIC RATS

2018 ◽  
Vol 33 (suppl_1) ◽  
pp. i162-i163
Author(s):  
SuMi Lee ◽  
Eu Gene Jeong ◽  
Sung Hyun Son ◽  
Hyuck Jae Choi ◽  
Young Ki Son ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Protein Diet ◽  
Low Protein Diet ◽  
Omega 3 ◽  
Omega 3 Fatty Acid ◽  
Low Protein

scholarly journals Maternal low protein diet in rats programmes fatty acid desaturase activities in the offspring

Diabetologia ◽  
1998 ◽  
Vol 41 (11) ◽  
pp. 1337-1342 ◽  
Author(s):  
S. E. Ozanne ◽  
N. D. Martensz ◽  
C. J. Petry ◽  
C. L Loizou ◽  
C. N. Hales
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Desaturase ◽  
Protein Diet ◽  
Low Protein Diet ◽  
Low Protein

scholarly journals Low-Protein Diet Supplemented with Medium-Chain Fatty Acid Glycerides Improves the Growth Performance and Intestinal Function in Post-Weaning Piglets

Animals ◽  
2020 ◽  
Vol 10 (10) ◽  
pp. 1852
Author(s):  
Zhijuan Cui ◽  
Xianze Wang ◽  
Zhenping Hou ◽  
Simeng Liao ◽  
Ming Qi ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Growth Performance ◽  
Chain Fatty Acid ◽  
Medium Chain Fatty Acid ◽  
Protein Diet ◽  
Low Protein Diet ◽  
Weaned Piglets ◽  
Medium Chain ◽  
Low Protein ◽  
Glycerol Monolaurate

Medium-chain fatty acid glycerides have been shown to provide energy for rapid oxidation in the body. The study was conducted to investigate the effects of dietary supplementation with medium-chain fatty acid glyceride on the growth performance and intestinal health of weaned piglets fed with a low-protein diet. Nighty healthy weaned piglets were randomly divided into five treatments: NP (Normal protein treatment, normal-protein diet no antibiotics included); NC (Negative control, low-protein diet no antibiotics included); PC (Positive control, low-protein diet +75 mg/kg quinocetone, 20 mg/kg virginiamycin and 50 mg/kg aureomycin); MCT (tricaprylin + tricaprin treatment, low-protein diet + tricaprylin + tricaprin); GML (glycerol monolaurate treatment, low-protein diet + glycerol monolaurate). The results showed that the average daily feed intake (ADFI) of the MCT treatment was significantly higher than that of the NP, NC treatments (p < 0.05). In the jejunum, the villus height of the GML treatment was significantly lower than that of the PC treatment (p < 0.05), and the number of goblet cells in the GML treatment was higher than that in the NC treatment (p < 0.05). Compared with the NC treatment, the MCT treatment significantly increased the level of claudin-1, Zonula occludens-1(ZO-1), while the GML treatment significantly increased the level of claudin-1, occludin, ZO-1 (p < 0.05). In the ileum, the level of ZO-1 in the GML treatment was significantly higher than that in the NP, NC, PC treatments (p < 0.05). Compared with the NC treatment, the GML treatment significantly increased the level of Secretory immunoglobulin A (SIgA) in the ileum and serum, while the MCT treatment significantly increased the level of SIgA and decreased the level of interleukin-6 (IL-6) in the ileum (p < 0.05). These results showed that the addition of medium-chain fatty acid glycerides to a low-protein diet could improve the growth performance and intestinal functional barrier of weaned piglets and also improve the immune function of weaned piglets.

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