Sulforaphane Inhibited Melanin Synthesis by Regulating Tyrosinase Gene Expression in B16 Mouse Melanoma Cells

2010 ◽  
Vol 74 (3) ◽  
pp. 579-582 ◽  
Author(s):  
Ichiro SHIRASUGI ◽  
Miyuki KAMADA ◽  
Takashi MATSUI ◽  
Yoichi SAKAKIBARA ◽  
Ming-Cheh LIU ◽  
...  
Keyword(s):  
Gene Expression ◽  
Melanoma Cells ◽  
Melanin Synthesis ◽  
Mouse Melanoma ◽  
Tyrosinase Gene ◽  
B16 Mouse Melanoma

Stimulation of melanin synthesis of B16-F10 mouse melanoma cells by bufalin

Life Sciences ◽  
1992 ◽  
Vol 51 (1) ◽  
pp. 17-24 ◽  
Author(s):  
Lisha Zhang ◽  
Takemi Yoshida ◽  
Yukio Kuroiwa
Keyword(s):  
Melanoma Cells ◽  
Melanin Synthesis ◽  
Mouse Melanoma ◽  
Stimulation Of

Non-malignant migration of B16 mouse melanoma cells in the neural crest and invasive growth in the eye cup of the chick embryo

2007 ◽  
Vol 17 (1) ◽  
pp. 17-30 ◽  
Author(s):  
Matthias Oppitz ◽  
Christian Busch ◽  
Gernot Schriek ◽  
Marco Metzger ◽  
Lothar Just ◽  
...  
Keyword(s):  
Chick Embryo ◽  
Neural Crest ◽  
Melanoma Cells ◽  
Invasive Growth ◽  
Mouse Melanoma ◽  
B16 Mouse Melanoma

scholarly journals Prevention of Melanin Formation by Yeast Cerebroside in B16 Mouse Melanoma Cells

2007 ◽  
Vol 56 (12) ◽  
pp. 645-648 ◽  
Author(s):  
Mikio Kinoshita ◽  
Naofumi Hori ◽  
Kazuhiko Aida ◽  
Tatsuya Sugawara ◽  
Masao Ohnishi
Keyword(s):  
Melanoma Cells ◽  
Mouse Melanoma ◽  
Melanin Formation ◽  
B16 Mouse Melanoma

scholarly journals Cycloalliin Inhibits Melanin Biosynthesis in B16 Mouse Melanoma Cells

2018 ◽  
Vol 24 (4) ◽  
pp. 627-633 ◽  
Author(s):  
Tomohiro Bito ◽  
Kyohei Koseki ◽  
Tomohiro Moriguchi ◽  
Yu Sasaki ◽  
Yukinori Yabuta ◽  
...  
Keyword(s):  
Melanoma Cells ◽  
Melanin Biosynthesis ◽  
Mouse Melanoma ◽  
B16 Mouse Melanoma

scholarly journals The Organogermanium Compound THGP Suppresses Melanin Synthesis via Complex Formation with L-DOPA on Mushroom Tyrosinase and in B16 4A5 Melanoma Cells

2019 ◽  
Vol 20 (19) ◽  
pp. 4785
Author(s):  
Junya Azumi ◽  
Tomoya Takeda ◽  
Yasuhiro Shimada ◽  
Hisashi Aso ◽  
Takashi Nakamura
Keyword(s):  
Gene Expression ◽  
Kojic Acid ◽  
Biological Activities ◽  
Melanoma Cells ◽  
Tyrosinase Activity ◽  
Melanin Synthesis ◽  
Mushroom Tyrosinase ◽  
Melanin Production ◽  
Organogermanium Compound ◽  
Or Gene

The organogermanium compound 3-(trihydroxygermyl)propanoic acid (THGP) has various biological activities. We previously reported that THGP forms a complex with cis-diol structures. L-3,4-Dihydroxyphenylalanine (L-DOPA), a precursor of melanin, contains a cis-diol structure in its catechol skeleton, and excessive melanin production causes skin darkening and staining. Thus, the cosmetic field is investigating substances that suppress melanin production. In this study, we investigated whether THGP inhibits melanin synthesis via the formation of a complex with L-DOPA using mushroom tyrosinase and B16 4A5 melanoma cells. The ability of THGP to interact with L-DOPA was analyzed by 1H-NMR, and the influence of THGP and/or kojic acid on melanin synthesis was investigated. We also examined the effect of THGP on cytotoxicity, tyrosinase activity, and gene expression and found that THGP interacted with L-DOPA, a precursor of melanin with a cis-diol structure. The results also showed that THGP inhibited melanin synthesis, exerted a synergistic effect with kojic acid, and did not affect tyrosinase activity or gene expression. These results suggest that THGP is a useful substrate that functions as an inhibitor of melanogenesis and that its effect is enhanced by combination with kojic acid.

Procyanidin Trimers to Pentamers Fractionated from Apple Inhibit Melanogenesis in B16 Mouse Melanoma Cells

2005 ◽  
Vol 53 (15) ◽  
pp. 6105-6111 ◽  
Author(s):  
Toshihiko Shoji ◽  
Saeko Masumoto ◽  
Nina Moriichi ◽  
Masuko Kobori ◽  
Tomomasa Kanda ◽  
...  
Keyword(s):  
Melanoma Cells ◽  
Mouse Melanoma ◽  
B16 Mouse Melanoma
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