Inhibitory Effect of Curcumin on IMP Dehydrogenase, the Target for Anticancer and Antiviral Chemotherapy Agents

2010 ◽  
Vol 74 (1) ◽  
pp. 185-187 ◽  
Author(s):  
Issei DAIRAKU ◽  
Yunkyung HAN ◽  
Noriyuki YANAKA ◽  
Norihisa KATO
Keyword(s):  
Inhibitory Effect ◽  
Imp Dehydrogenase ◽  
Antiviral Chemotherapy ◽  
Chemotherapy Agents

ChemInform Abstract: IMP Dehydrogenase as a Target of Antitumor and Antiviral Chemotherapy

ChemInform ◽  
2010 ◽  
Vol 27 (47) ◽  
pp. no-no
Author(s):  
P. FRANCHETTI ◽  
L. CAPPELLACCI ◽  
M. GRIFANTINI
Keyword(s):  
Imp Dehydrogenase ◽  
Antiviral Chemotherapy

Apoptosis and Caspase 3 Pathway Role on Anti-Proliferative Effects of Scrophulariaoxy Sepala Methanolic Extract on Caco-2 Cells

Drug Research ◽  
2017 ◽  
Vol 67 (09) ◽  
pp. 547-552 ◽  
Author(s):  
Ali Namvaran ◽  
Mehdi Fazeli ◽  
Safar Farajnia ◽  
Gholamreza Hamidian ◽  
Hassan Rezazadeh
Keyword(s):  
Caspase 3 ◽  
Methanolic Extract ◽  
Inhibitory Effect ◽  
Control Group ◽  
Common Source ◽  
Dependent Manner ◽  
High Doses ◽  
New Treatment ◽  
Induced Apoptosis ◽  
Chemotherapy Agents

AbstractColorectal cancer is one the most important malignancies worldwide and finding new treatment option for this cancer is of high priority. Natural compounds are common source of drugs for treatment of various diseases including cancers. The aim of this study was to investigate the effects of Scrophularia oxysepala extract on Caco-2 cells and explore the possible role of caspase 3 pathway in inducing cell death in this cancer cells in compare with chemotherapy agents of cisplatin and capecitabine. The methanolic extract of Scrophularia oxysepala (SO) was prepared by drench method. The IC50 of extract, cisplatin and capecitabine on Caco-2 cells were determined by MTT assay. The effect of SO extract on caspase 3 expression and inducing apoptosis were determined using TUNEL assay and caspase 3 ELISA methods, respectively. The IC50 of SO extract, cisplatin and capecitabine were 300, 195 and 80 µg/ml, respectively. Analysis for apoptosis revealed that SO methanolic extract increased apoptosis significantly (P<0.001) compared with control group. The effect of high doses of SO extract on apoptosis induction were comparable to cisplatin but significantly were higher than capecitabine. Only high doses of SO methanolic extract showed significant effects (P<0.05) on increasing caspase 3 compared to control group. The methanolic extract of SO showed inhibitory effect on Caco-2 cells and induced apoptosis in a dose-dependent manner comparable to cisplatin and higher than capecitabine 2 commonly used chemotherapeutic agent for various cancers.

scholarly journals Anti-inflammatory Compounds from Ampelopsis cantoniensis

2015 ◽  
Vol 10 (3) ◽  
pp. 1934578X1501000 ◽  
Author(s):  
Nguyen Van Thu ◽  
Dao Cuong ◽  
Tran Manh Hung ◽  
Hoang Van Luong ◽  
Mi Hee Woo ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Inhibitory Effect ◽  
Raw 264.7 Cells ◽  
Chemical Components ◽  
No Production ◽  
Anti Inflammatory ◽  
Oxide Synthase ◽  
Chemotherapy Agents ◽  
First Time ◽  
Dose Dependent

Many natural products have been shown to have an inhibitory effect on nitric oxide (NO), and are used as chemotherapy agents for inflammation disease. The current study was designed to evaluate the anti-inflammatory activity of chemical components from the leaves of Ampelopsis cantoniensis. Sixteen compounds (1–16) were isolated and identified. Phloretin (5) and 5,7,3′,5′-tetrahydroxyflavanone (16) inhibited nitric oxide (NO) production with IC50 values of 5.2, and 18.5 μM, respectively. The inhibitory effect of compounds 5 and 16 were accompanied by dose-dependent decreases in LPS-induced nitric oxide synthase (iNOS) in RAW 264.7 cells, respectively. This study investigated the significant anti-inflammatory properties of isolated compounds from the leaves of A. cantoniensis for the first time. The findings demonstrate that A. cantoniensis could be used beneficially in the treatment of inflammation disease.

Inhibitory effect of melatonin on nitric oxide synthase in rat enteric nervous system

2001 ◽  
Vol 120 (5) ◽  
pp. A176-A176
Author(s):  
P KOPPITZ ◽  
M STORR ◽  
D SAUR ◽  
M KURJAK ◽  
H ALLESCHER
Keyword(s):  
Nitric Oxide ◽  
Nervous System ◽  
Nitric Oxide Synthase ◽  
Enteric Nervous System ◽  
Inhibitory Effect ◽  
Oxide Synthase

Inhibitory effect of proton pump inhibitors against chemotaxis of Helicobacter pylori

2001 ◽  
Vol 120 (5) ◽  
pp. A655-A656
Author(s):  
H NAKAMURA ◽  
H YOSHIYAMA ◽  
H YANAI ◽  
M SHIRAL ◽  
T NAKAZAWA ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Proton Pump Inhibitors ◽  
Proton Pump ◽  
Inhibitory Effect

The Nature of the Inhibitory Effect of Normal Human Gastric Jiuice on Heidenhain Pouch Dogs

1958 ◽  
Vol 34 (2) ◽  
pp. 181-187 ◽  
Author(s):  
William O. Smith ◽  
Robert Hoke ◽  
Jerome Landy ◽  
Ranwel Caputto ◽  
Stewart Wolf
Keyword(s):  
Inhibitory Effect ◽  
Heidenhain Pouch ◽  
Normal Human

Inhibitory effect of Rhamnus alpinus and Rhamnus saxatilis extracts on chemokine secretion induced by lipopolysaccharide in monocyte-derived macrophages

Planta Medica ◽  
2008 ◽  
Vol 74 (09) ◽  
Author(s):  
F Epifano ◽  
L Menghini ◽  
A Chiavaroli ◽  
G Orlando ◽  
VD La ◽  
...  
Keyword(s):  
Inhibitory Effect
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