ChemInform Abstract: IMP Dehydrogenase as a Target of Antitumor and Antiviral Chemotherapy

ChemInform ◽  
2010 ◽  
Vol 27 (47) ◽  
pp. no-no
Author(s):  
P. FRANCHETTI ◽  
L. CAPPELLACCI ◽  
M. GRIFANTINI
Keyword(s):  
Imp Dehydrogenase ◽  
Antiviral Chemotherapy

Enzymes of Human Herpesviruses

1992 ◽  
Vol 57 (8) ◽  
pp. 1577-1612 ◽  
Author(s):  
Pavel Kramata ◽  
Ivan Votruba
Keyword(s):  
Binding Protein ◽  
Human Herpesvirus ◽  
Dna Helicase ◽  
Point Of View ◽  
Uracil Dna Glycosylase ◽  
Replication Complex ◽  
Viral Genomes ◽  
Origin Binding Protein ◽  
Antiviral Chemotherapy ◽  
Human Herpesviruses

The properties of human herpesvirus-encoded enzymes are reviewed and the importance of sequence analysis of viral genomes as well as the experiments on characteristics of enzymes isolated from infected cell cultures are emphasized. The following enzymes are described in detail: DNA replication complex consisting of DNA polymerase, DNA helicase-primase, single-stranded DNA binding protein and origin binding protein, further thymidine kinase, ribonucleotide reductase, deoxyuridine triphosphatase as well as uracil-DNA-glycosylase, deoxyribonuclease and protein kinase. The importance of these enzymes from the point of view of antiviral chemotherapy is discussed.

IMP dehydrogenase, an enzyme linked with proliferation and malignancy

Nature ◽  
1975 ◽  
Vol 256 (5515) ◽  
pp. 331-333 ◽  
Author(s):  
ROBERT C. JACKSON ◽  
GEORGE WEBER ◽  
HAROLD P. MORRIS
Keyword(s):  
Imp Dehydrogenase

scholarly journals Ribavirin induces widespread accumulation of IMP dehydrogenase into rods/rings structures in multiple major mouse organs

2019 ◽  
Vol 162 ◽  
pp. 130-135 ◽  
Author(s):  
Gerson Dierley Keppeke ◽  
S. John Calise ◽  
Edward K.L. Chan ◽  
Luis Eduardo C. Andrade
Keyword(s):  
Imp Dehydrogenase

Potential targets for antiviral chemotherapy

1986 ◽  
Vol 6 (6) ◽  
pp. 311-328 ◽  
Author(s):  
William H. Prusoff ◽  
Tai-Shun Lin ◽  
Marcia Zucker
Keyword(s):  
Antiviral Chemotherapy

Differential antiviral activity of several IMP dehydrogenase inhibitors

1997 ◽  
Vol 34 (2) ◽  
pp. A87
Author(s):  
J. Neyts ◽  
G. Andrei ◽  
E. De Clercq
Keyword(s):  
Antiviral Activity ◽  
Imp Dehydrogenase

scholarly journals New antifungal and antiviral chemotherapy.

BMJ ◽  
1983 ◽  
Vol 286 (6380) ◽  
pp. 1802-1804 ◽  
Author(s):  
J C Stewart ◽  
J Ferguson ◽  
P Davey
Keyword(s):  
Antiviral Chemotherapy

A broad influenza virus inhibitor acting via IMP dehydrogenase and in synergism with ribavirin

2021 ◽  
pp. 105208
Author(s):  
Evelien Vanderlinden ◽  
Arnaud Marchand ◽  
Ria Van Berwaer ◽  
Wim van Dam ◽  
Philippe Arzel ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Imp Dehydrogenase ◽  
Virus Inhibitor
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