Cystatin C in Milk Basic Protein (MBP) and Its Inhibitory Effect on Bone Resorptionin Vitro

2002 ◽  
Vol 66 (12) ◽  
pp. 2531-2536 ◽  
Author(s):  
Yasuhiro MATSUOKA ◽  
Atsushi SERIZAWA ◽  
Tomoe YOSHIOKA ◽  
Jun-ichi YAMAMURA ◽  
Yoshikazu MORITA ◽  
...  
Keyword(s):  
Cystatin C ◽  
Basic Protein ◽  
Inhibitory Effect ◽  
Milk Basic Protein

A new insight into cystatin C contained in milk basic protein to bone metabolism: Effects on osteoclasts and osteoblastic MC3T3-E1 cells in vitro

2018 ◽  
Vol 89 (7) ◽  
pp. 1027-1032 ◽  
Author(s):  
Takehiko Yasueda ◽  
Yusuke Abe ◽  
Mayumi Shiba ◽  
Yoshie Kamo ◽  
Yasuyuki Seto
Keyword(s):  
Bone Metabolism ◽  
Cystatin C ◽  
Basic Protein ◽  
Milk Basic Protein ◽  
Insight Into

scholarly journals Milk basic protein supplementation exerts an anti-inflammatory effect in a food-allergic enteropathy model mouse

2018 ◽  
Vol 101 (3) ◽  
pp. 1852-1863 ◽  
Author(s):  
Aiko Ono-Ohmachi ◽  
Haruyo Nakajima-Adachi ◽  
Yoshikazu Morita ◽  
Ken Kato ◽  
Satoshi Hachimura
Keyword(s):  
Basic Protein ◽  
Protein Supplementation ◽  
Model Mouse ◽  
Anti Inflammatory ◽  
Milk Basic Protein ◽  
Inflammatory Effect

Milk Basic Protein Promotes Bone Formation and Suppresses Bone Resorption in Healthy Adult Men

2001 ◽  
Vol 65 (6) ◽  
pp. 1353-1357 ◽  
Author(s):  
Yasuhiro TOBA ◽  
Yukihiro TAKADA ◽  
Yasuhiro MATSUOKA ◽  
Yoshikazu MORITA ◽  
Mutsumi MOTOURI ◽  
...  
Keyword(s):  
Bone Resorption ◽  
Bone Formation ◽  
Basic Protein ◽  
Healthy Adult ◽  
Adult Men ◽  
Milk Basic Protein

Milk Basic Protein Increases Bone Mineral Density and Improves Bone Metabolism in Humans

2004 ◽  
pp. 413-429
Author(s):  
Yukihiro Takada ◽  
Seiichiro Aoe ◽  
Yasuhiro Toba ◽  
Kazuhiro Uenishi ◽  
Akira Takeuchi ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Metabolism ◽  
Bone Mineral ◽  
Basic Protein ◽  
Mineral Density ◽  
Milk Basic Protein

scholarly journals Translation of myelin basic protein mRNA in oligodendrocytes is regulated by integrin activation and hnRNP-K

2011 ◽  
Vol 192 (5) ◽  
pp. 797-811 ◽  
Author(s):  
Lisbeth S. Laursen ◽  
Colin W. Chan ◽  
Charles ffrench-Constant
Keyword(s):  
Protein Synthesis ◽  
Myelin Basic Protein ◽  
Myelin Sheath ◽  
Basic Protein ◽  
Inhibitory Effect ◽  
Integrin Activation ◽  
Hnrnp K ◽  
Sheath Formation ◽  
The Central Nervous System ◽  
Mrna Binding

Myelination in the central nervous system provides a unique example of how cells establish asymmetry. The myelinating cell, the oligodendrocyte, extends processes to and wraps multiple axons of different diameter, keeping the number of wraps proportional to the axon diameter. Local regulation of protein synthesis represents one mechanism used to control the different requirements for myelin sheath at each axo–glia interaction. Prior work has established that β1-integrins are involved in the axoglial interactions that initiate myelination. Here, we show that integrin activation regulates translation of a key sheath protein, myelin basic protein (MBP), by reversing the inhibitory effect of the mRNA 3′UTR. During oligodendrocyte differentiation and myelination α6β1-integrin interacts with hnRNP-K, an mRNA-binding protein, which binds to MBP mRNA and translocates from the nucleus to the myelin sheath. Furthermore, knockdown of hnRNP-K inhibits MBP protein synthesis during myelination. Together, these results identify a novel pathway by which axoglial adhesion molecules coordinate MBP synthesis with myelin sheath formation.

Milk basic protein increases ghrelin secretion and bone mineral density in rodents

Nutrition ◽  
2017 ◽  
Vol 39-40 ◽  
pp. 15-19 ◽  
Author(s):  
Yuko Ishida ◽  
Rakhi Chacrabati ◽  
Aiko Ono-Ohmachi ◽  
Zhi Gong ◽  
Chika Ikenoya ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Basic Protein ◽  
Mineral Density ◽  
Ghrelin Secretion ◽  
Milk Basic Protein

Role and advantage of cystatin C in kidney function monitoring during retroviral therapy

2017 ◽  
Vol 53 (1) ◽  
pp. 33-40
Author(s):  
Maria Warwas ◽  
Katarzyna Juszczyńska ◽  
Ewa Mulewicz ◽  
Jakub Gburek
Keyword(s):  
Kidney Function ◽  
Cystatin C ◽  
Clinical Investigation ◽  
Inhibitory Effect ◽  
Antiretroviral Drugs ◽  
Hiv Protease ◽  
Hiv Virus ◽  
Infection And Inflammation ◽  
Virus Strains

The aim of the study is to evaluate the utility of cystatin C (Cys C) determination in monitoring of HIV seropositive patients, based on recent literature concerning clinical investigation. Determination of serum CysC concentration can be helpful in monitoring the kidney function and eGFR (estimated GFR) calculation, however infection and inflammation markers influence should be included. A risk assessment of the appearance of cardiovascular incidents and risks of the all-cause mortality can be the other application for this parameter. The urinary CysC concentration can serve as the diagnostic marker of kidney tubular injuries triggered with adverse effects of antiretroviral drugs eg. tenofovir. In order to introduce applications into the routine clinical practice, further research is essential. Research concerning antiviral activity of cystatin C suggest, that CysC suppresses the viral replication due to inhibition of HIV protease, but in some cases its inhibitory effect on cathepsin B may be harmful and cause progression of the infection. In order that CysC could effectively use in the future, further experiments are needed to evaluate its effect on all sort virus strains, both dependent and independent of CD4+ T-lymphocytes, strains of the HIV virus.

Milk basic protein: a novel protective function of milk against osteoporosis

Bone ◽  
2000 ◽  
Vol 27 (3) ◽  
pp. 403-408 ◽  
Author(s):  
Y. Toba ◽  
Y. Takada ◽  
J. Yamamura ◽  
M. Tanaka ◽  
Y. Matsuoka ◽  
...  
Keyword(s):  
Basic Protein ◽  
Protein A ◽  
Protective Function ◽  
Milk Basic Protein
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