Milk Basic Protein Promotes Bone Formation and Suppresses Bone Resorption in Healthy Adult Men

2001 ◽  
Vol 65 (6) ◽  
pp. 1353-1357 ◽  
Author(s):  
Yasuhiro TOBA ◽  
Yukihiro TAKADA ◽  
Yasuhiro MATSUOKA ◽  
Yoshikazu MORITA ◽  
Mutsumi MOTOURI ◽  
...  
Keyword(s):  
Bone Resorption ◽  
Bone Formation ◽  
Basic Protein ◽  
Healthy Adult ◽  
Adult Men ◽  
Milk Basic Protein

scholarly journals Milk Basic Protein (MBP) Increases Radial Bone Mineral Density in Healthy Adult Women

2002 ◽  
Vol 66 (3) ◽  
pp. 702-704 ◽  
Author(s):  
Jun-ichi YAMAMURA ◽  
Seiichiro AOE ◽  
Yasuhiro TOBA ◽  
Mutsumi MOTOURI ◽  
Hiroshi KAWAKAMI ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Basic Protein ◽  
Healthy Adult ◽  
Adult Women ◽  
Mineral Density ◽  
Milk Basic Protein ◽  
Radial Bone

Milk basic protein increases alveolar bone formation in rat experimental periodontitis

2007 ◽  
Vol 42 (1) ◽  
pp. 85-89 ◽  
Author(s):  
H. Seto ◽  
Y. Toba ◽  
Y. Takada ◽  
H. Kawakami ◽  
H. Ohba ◽  
...  
Keyword(s):  
Bone Formation ◽  
Basic Protein ◽  
Alveolar Bone ◽  
Experimental Periodontitis ◽  
Milk Basic Protein

scholarly journals Early effects of androgen deprivation on bone and mineral homeostasis in adult men: a prospective cohort study

2020 ◽  
Vol 183 (2) ◽  
pp. 181-189
Author(s):  
Rougin Khalil ◽  
Leen Antonio ◽  
Michaël R Laurent ◽  
Karel David ◽  
Na Ri Kim ◽  
...  
Keyword(s):  
Cohort Study ◽  
Calcium Phosphate ◽  
Bone Resorption ◽  
Bone Formation ◽  
Bone Turnover ◽  
Prospective Cohort ◽  
Phosphate Homeostasis ◽  
Adult Men ◽  
Early Effects

Objective Long-term androgen deprivation therapy (ADT) negatively influences bone. The short-term effects on bone and mineral homeostasis are less known. Therefore, we aimed to investigate the early effects of ADT on calcium/phosphate homeostasis and bone turnover. Design Prospective cohort study. Methods Eugonadal adult, male sex offenders, who were referred for ADT to the endocrine outpatient clinic, received cyproterone acetate. Changes in blood markers of calcium/phosphate homeostasis and bone turnover between baseline and first follow-up visit were studied. Results Of 26 screened patients, 17 were included. The median age was 44 (range 20–75) years. The median time interval between baseline and first follow-up was 13 (6–27) weeks. Compared to baseline, an 81% decrease was observed for median total testosterone (to 3.4 nmol/L (0.4–12.2); P < 0.0001) and free testosterone (to 0.06 nmol/L (0.01–0.18); P < 0.0001). Median total estradiol decreased by 71% (to 17.6 pmol/L (4.7–35.6); P < 0.0001). Increased serum calcium (P < 0.0001) and phosphate (P = 0.0016) was observed, paralleled by decreased PTH (P = 0.0156) and 1,25-dihydroxyvitamin D3 (P = 0.0134). The stable calcium isotope ratio (δ44/42Ca) decreased (P = 0.0458), indicating net calcium loss from bone. Bone-specific alkaline phosphatase and osteocalcin decreased (P < 0.0001 and P = 0.0056, respectively), periostin tended to decrease (P = 0.0500), whereas sclerostin increased (P < 0.0001), indicating suppressed bone formation. Serum bone resorption markers (TRAP, CTX) were unaltered. Conclusions In adult men, calcium release from the skeleton occurs early following sex steroid deprivation, reflecting early bone resorption. The increase of sclerostin and reduction of bone formation markers, without changes in resorption markers, suggests a dominant negative effect on bone formation in the acute phase.

Controlled Trial of the Effects of Milk Basic Protein (MBP) Supplementation on Bone Metabolism in Healthy Adult Women

2001 ◽  
Vol 65 (4) ◽  
pp. 913-918 ◽  
Author(s):  
Seichiro AOE ◽  
Yasuhiro TOBA ◽  
Jun-ichi YAMAMURA ◽  
Hiroshi KAWAKAMI ◽  
Masatoshi YAHIRO ◽  
...  
Keyword(s):  
Bone Metabolism ◽  
Basic Protein ◽  
Healthy Adult ◽  
Controlled Trial ◽  
Adult Women ◽  
Milk Basic Protein

Co-purification of bone resorbing activity and adenylate cyclase stimulating activity from human tumours associated with the humoral hypercalcaemia of malignancy

1987 ◽  
Vol 114 (1) ◽  
pp. 18-26 ◽  
Author(s):  
Chohei Shigeno ◽  
Itsuo Yamamoto ◽  
Shegiharu Dokoh ◽  
Megumu Hino ◽  
Jun Aoki ◽  
...  
Keyword(s):  
Bone Resorption ◽  
High Performance ◽  
Basic Protein ◽  
Gel Filtration ◽  
Exchange Chromatography ◽  
Protein Factor ◽  
Human Tumours ◽  
Acid Stable ◽  
Bone Resorbing Activity

Abstract. We have partially purified a tumour factor capable of stimulating both bone resorption in vitro and cAMP accumulation in osteoblastic ROS 17/2 cells from three human tumours associated with humoral hypercalcaemia of malignancy. Purification of tumour factor by sequential acid urea extraction, gel filtration and cation-exchange chromatography, reverse-phase high performance liquid chromatography followed by analytical isoelectric focussing provided a basic protein (pI > 9.3) with a molecular weight of approximately 13 000 as a major component of the final preparation which retained both the two bioactivities. Bone resorbing activity and cAMP-increasing activity in purified factor correlated with each other. cAMP-increasing activity of the factor was heat- and acid-stable, but sensitive to alkaline ambient pH. Treatment with trypsin destroyed cAMP-increasing activity of the factor. Synthetic parathyroid hormone (PTH) antagonist, human PTH-(3– 34) completely inhibited the cAMP-increasing activity of the factor. The results suggest that this protein factor, having its effects on both osteoclastic and osteoblastic functions, may be involved in development of enhanced bone resorption in some patients with humoral hypercalcaemia of malignancy.

Effect of 4-week cyclic stretching program on muscle properties and physical performance in healthy adult men

2020 ◽  
Vol 60 (1) ◽  
Author(s):  
Shogo Sakai ◽  
Noriaki Maeda ◽  
Junpei Sasadai ◽  
Somu Kotoshiba ◽  
Keitaro Anami ◽  
...  
Keyword(s):  
Physical Performance ◽  
Healthy Adult ◽  
Muscle Properties ◽  
Adult Men ◽  
Cyclic Stretching

Changes in bone metabolism associated with exposure to industrial vibration

2020 ◽  
pp. 766-766
Author(s):  
A. V. Sukhova ◽  
E. N. Kryuchkova
Keyword(s):  
Bone Mineral Density ◽  
Alkaline Phosphatase ◽  
Bone Resorption ◽  
Bone Formation ◽  
Bone Metabolism ◽  
Biochemical Markers ◽  
Mineral Density ◽  
Local Vibration ◽  
Markers Of Bone Formation

The influence of general and local vibration on bone remodeling processes is investigated. The interrelations between the long - term exposure of industrial vibration and indicators of bone mineral density (T-and Z-criteria), biochemical markers of bone formation (osteocalcin, alkaline phosphatase) and bone resorption (ionized calcium, calcium/creatinine) were established.

scholarly journals Pharmacological inhibition of TAK1, with the selective inhibitor takinib, alleviates clinical manifestation of arthritis in CIA mice

2019 ◽  
Vol 21 (1) ◽  
Author(s):  
Scott A. Scarneo ◽  
Liesl S. Eibschutz ◽  
Phillip J. Bendele ◽  
Kelly W. Yang ◽  
Juliane Totzke ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Bone Resorption ◽  
Bone Formation ◽  
Transforming Growth Factor Beta ◽  
Transforming Growth Factor ◽  
Inflammatory Diseases ◽  
Cartilage Damage ◽  
Cytokine Signaling ◽  
Periosteal Bone Formation ◽  
Bone Width

Abstract Objectives To examine the ability of takinib, a selective transforming growth factor beta-activated kinase 1 (TAK1) inhibitor, to reduce the severity of murine type II collagen-induced arthritis (CIA), and to affect function of synovial cells. Methods Following the induction of CIA, mice were treated daily with takinib (50 mg/kg) and clinical scores assessed. Thirty-six days post-CIA induction, histology was performed on various joints of treated and vehicle-treated animals. Inflammation, pannus, cartilage damage, bone resorption, and periosteal bone formation were quantified. Furthermore, pharmacokinetics of takinib were evaluated by LC-MS in various tissues. Rheumatoid arthritis fibroblast-like synoviocytes (RA-FLS) cells were cultured with 10 μM takinib and cytokine secretion analyzed by cytokine/chemokine proteome array. Cytotoxicity of takinib for RA-FLS was measured with 24 to 48 h cultures in the presence or absence of tumor necrosis factor (TNF). Results Here, we show takinib’s ability to reduce the clinical score in the CIA mouse model of rheumatoid arthritis (RA) (p < 0.001). TAK1 inhibition reduced inflammation (p < 0.01), cartilage damage (p < 0.01), pannus, bone resorption, and periosteal bone formation and periosteal bone width in all joints of treated mice compared to vehicle treated. Significant reduction of inflammation (p < 0.004) and cartilage damage (p < 0.004) were observed in the knees of diseased treated animals, with moderate reduction seen in the forepaws and hind paws. Furthermore, the pharmacokinetics of takinib show rapid plasma clearance (t½ = 21 min). In stimulated RA-FLS cells, takinib reduced GROα, G-CSF, and ICAM-1 pro-inflammatory cytokine signaling. Conclusion Our findings support the hypothesis that TAK1 targeted therapy represents a novel therapeutic axis to treat RA and other inflammatory diseases.

scholarly journals Milk basic protein supplementation exerts an anti-inflammatory effect in a food-allergic enteropathy model mouse

2018 ◽  
Vol 101 (3) ◽  
pp. 1852-1863 ◽  
Author(s):  
Aiko Ono-Ohmachi ◽  
Haruyo Nakajima-Adachi ◽  
Yoshikazu Morita ◽  
Ken Kato ◽  
Satoshi Hachimura
Keyword(s):  
Basic Protein ◽  
Protein Supplementation ◽  
Model Mouse ◽  
Anti Inflammatory ◽  
Milk Basic Protein ◽  
Inflammatory Effect
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