Synthetic and Structure-Activity Relationship Studies on Bioactive Natural Products

2013 ◽  
Vol 77 (3) ◽  
pp. 446-454 ◽  
Author(s):  
Kouji KURAMOCHI
Keyword(s):  
Natural Products ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Bioactive Natural Products ◽  
Structure Activity

scholarly journals Chemo- and site-selective derivatizations of natural products enabling biological studies

2014 ◽  
Vol 31 (3) ◽  
pp. 318-334 ◽  
Author(s):  
Omar Robles ◽  
Daniel Romo
Keyword(s):  
Natural Products ◽  
Functional Group ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Reactive Group ◽  
Bioactive Natural Products ◽  
Sar Studies ◽  
Structure Activity ◽  
Biological Studies ◽  
Site Selective

The direct chemo- and site-selective modification of native bioactive natural products (NP) for structure–activity relationship (SAR) studies and cellular probe synthesis has recently begun to be addressed (FG = functional group). This review highlights selected recent examples of these functionalization strategies, including those that simultaneously introduce a linker and reactive group (gray structure) for subsequent conjugation to reporter tags.

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