scholarly journals Radioprotective Property of the Ethanolic Extract of Piper betel Leaf

2005 ◽  
Vol 46 (2) ◽  
pp. 165-171 ◽  
Author(s):  
Sayanti BHATTACHARYA ◽  
Mahesh SUBRAMANIAN ◽  
Susri ROYCHOWDHURY ◽  
Ajay K. BAURI ◽  
Jaya P. KAMAT ◽  
...  
Keyword(s):  
Ethanolic Extract ◽  
Radioprotective Property ◽  
Betel Leaf ◽  
Piper Betel Leaf

scholarly journals Betel (Piper betle L.) leaf ethanolic extracts dechlorophyllized using different methods: antioxidant and antibacterial activities, and application for shelf-life extension of Nile tilapia (Oreochromis niloticus) fillets

RSC Advances ◽  
2021 ◽  
Vol 11 (29) ◽  
pp. 17630-17641
Author(s):  
Mohamed Tagrida ◽  
Soottawat Benjakul
Keyword(s):  
Shelf Life ◽  
Nile Tilapia ◽  
Ethanolic Extract ◽  
Antibacterial Activities ◽  
Life Extension ◽  
Piper Betle ◽  
Refrigerated Storage ◽  
Betel Leaf ◽  
Nile Tilapia Oreochromis Niloticus ◽  
Ethanolic Extracts

Betel leaf ethanolic extract dechlorophyllized using sedimentation (BLEE-SED) exhibited enhanced antioxidant and antibacterial activities. BLEE-SED could extend the shelf-life of Nile tilapia fillets during refrigerated storage (4 °C) up to 9 days.

Increased sensitivity of Hep G2 cells toward the cytotoxicity of cisplatin by the treatment of piper betel leaf extract

2005 ◽  
Vol 80 (6) ◽  
pp. 319-327 ◽  
Author(s):  
Shun-Chieh Young ◽  
Chau-Jong Wang ◽  
Jeng-Dong Hsu ◽  
Jui-Ling Hsu ◽  
Fen-Pi Chou
Keyword(s):  
Leaf Extract ◽  
Hep G2 ◽  
Hep G2 Cells ◽  
Betel Leaf ◽  
Increased Sensitivity ◽  
G2 Cells ◽  
Piper Betel Leaf

scholarly journals Piper betel leaf extract: anticancer benefits and bio-guided fractionation to identify active principles for prostate cancer management

2013 ◽  
Vol 34 (7) ◽  
pp. 1558-1566 ◽  
Author(s):  
Rutugandha Paranjpe ◽  
Sushma R. Gundala ◽  
N. Lakshminarayana ◽  
Arpana Sagwal ◽  
Ghazia Asif ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Leaf Extract ◽  
Betel Leaf ◽  
Cancer Management ◽  
Prostate Cancer Management ◽  
Piper Betel Leaf

scholarly journals Determination of phenolic contents and antioxidant activity test of ethanol extract of Sirih merah (Piper crocatum Ruiz & Pav.) leaves using the DPPH method

2021 ◽  
Vol 13 (2) ◽  
pp. 137-142
Author(s):  
Kasta Gurning ◽  
◽  
Sifikal Lumbangaol ◽  
Risanti F. R. Situmorang ◽  
Saronom Silaban ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Total Phenolic Content ◽  
Phenolic Content ◽  
Ethanolic Extract ◽  
Ethanol Extract ◽  
Extraction Process ◽  
Total Phenolic ◽  
Betel Leaf ◽  
Dpph Method

The research objectives were to identify the secondary metabolite components, total phenolic content and determine the antioxidant activity of the ethanol extract of red betel leaf (Piper crocatum Ruiz & Pav.). The extraction process was carried out by materation using ethanol as a solvent. Determination of total phenolic content was carried out colorimetrically with Folin-Ciocalteu reagent measured at a maximum wavelength of 765 nm. Determination of antioxidant activity using the DPPH method measured by spectrophotometry at a maximum wavelength of 517 nm. The results of phytochemical screening of the ethanolic extract of red betel leaf contain secondary metabolites, including flavonoid, phenolic, tannin, alkaloids, steroids, and triterpenoids. The total phenolic content of the red betel leaf ethanol extract was 0.949±0.003 mg GAE/g d.w. and has antioxidant activity (IC50) 84,656 including strong category as an antioxidant. Keywords: Piper crocatum Ruiz & Pav., Antioxidant, Ethanol extract, Folin-Ciocalteu and DPPH

scholarly journals Efektivitas Perlakuan Kombinatif Plasma Medis dan Ekstrak Daun Sirih untuk Mempercepat Penyembuhan Luka Fase Proliferasi pada Model Mencit Diabetik

2019 ◽  
Vol 15 (2) ◽  
pp. 81
Author(s):  
Eka Sakti Wahyuningtyas ◽  
Nasruddin Nasruddin ◽  
Heni Setyowati Esti Rahayu ◽  
Heni Lutfiyati ◽  
Isabella Meliawati Sikumbang ◽  
...  
Keyword(s):  
Wound Healing ◽  
Leaf Extract ◽  
Plasma Jet ◽  
Diabetic Wound ◽  
Diabetic Mice ◽  
Plasma Medicine ◽  
Betel Leaf ◽  
Diabetic Wound Healing ◽  
Diabetic Wounds ◽  
Piper Betel Leaf

The continued increase in the number of people with Diabetes Mellitus (DM) in Indonesia is a serious problem. One of the big problems for people with Diabetes Mellitus (DM) is the emergence of complications of diabetic wounds. To date the strategy for treatment of diabetic wounds has been limited to the use of wound dressing, cell therapy and oxygen therapy. The problem is that the strategy is not fully successful. Thus, it is very important to look for new strategies to improve the quality of diabetic wound healing, such as by applying a combination of plasma medicine and local natural product, like the extraction of Daun sirih (Piper betle) leaves. Plasma medicine is a relatively new and multidisciplinary study involving plasma science, biomedical, pharmaceutical and other health sciences aimed at applying plasma to therapeutic health. Plasma is the fourth phase of matter, after the solid, liquid and gas phase. The medical aspects of plasma are related to the ability of plasma to produce biological molecules Reactive Oxygen and Nitrogen Species (RONS). If RONS is controlled in the right dosage it can be efficacious for health therapy. This study intends to examine the effects of combinative treatment of plasma medicine and Piper betel leaf extract for proliferation phase of wound healing in diabetic small animal model. This study used male Balb c mice with acute wounds which were divided into 5 groups, namely groups of untreated normal mice (ND-TP), groups of untreated diabetic mice (D-TP), groups of diabetic mice wounds with Piper betel leaf extract (DS ), the wound group of diabetic mice with plasma medicine (DP) and the wound group of diabetic mice with plasma medicine and Piper betel leaf (DPS). The plasma medicine was treated on wound with condition non-contact style (the plasma jet did not touch the wound) with a distance of plasma jet reactor nozzle to the surface of wound about 20 mm, for 2 minutes, every day. Macroscopic observation of wounds is carried out every day from day 0 to 7. On day 7 it was seen that the size of the wound area for D-P-S was smaller than the other groups. The results of this study indicated that Piper betel leaf extract can potentially be used to optimize the performance of plasma medicine in accelerating diabetic wound healing during the proliferation phase. Further investigation, however, is important to be conducted to study the effect for all phases of wound healing and its mechanism histo-pathologically.

scholarly journals Effect of Piper betel leaf extract on learning and memory in Aluminium chloride induced Alzheimer’s disease in Wistar rats

2019 ◽  
Vol 12 (3) ◽  
pp. 1425-1431
Author(s):  
Shreeraksha Upadhyaya ◽  
Shivaprakash Gangachannaiah ◽  
Pallavi Lakshmi Chandrashekar
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Wistar Rats ◽  
Treated Group ◽  
Aluminium Chloride ◽  
Morris Water Maze Test ◽  
Control Group ◽  
Betel Leaf ◽  
Maze Test ◽  
Piper Betel Leaf

Alzheimer's disease is a common neurological disorder affecting a significant proportion of the elderly population.There are only a few drugs which can be used safely to treat it. We sought to investigate for the first time Piper betel leaf, a postmeal mouth freshener for its potential use in Alzheimer's disease. Five groups of male Wistar rats with six rats in each group aged 10-12 weeks were used. The control group received the distilled water, aluminium chloride (AlCl3) group was treated with AlCl3, the standard group was treated with rivastigmine with AlCl3, and the two test groups received piper betel leaf extract (PBE) at doses of 400mg/kg and 500mg/kg body weight with AlCl3. AlCl3 was administered orally for 42 days in all the treated groups. Memory and learning were evaluated by Morris water maze test and Passive avoidance test.The results of the Morris water maze test showed reduced mean escape latency period in all the groups on trial day three (P≤0.05) and on trial day four (P ≤0.01) compared to AlCl3 group. The retention of spatial memory by probe trial showed that PBE and rivastigmine treated group spent more time in the target (platform) quadrant when compared to AlCl3 group (P≤0.01). The passive avoidance test showed a significant increase in step through latency in standard and test groups compared to the AlCl3 treated group. The weight of the rats treated with AlCl3 and PBE was reduced at the end of the treatment period while increased in standard and control group. The study shows the beneficial effects of Piper betel leaves in Alzheimer’s disease by significantly improving the learning and memory functions in rats.

scholarly journals Optimasi Konsentrasi Ekstrak dan Bahan Pengikat Polivinil Pirolidon pada Granul Ekstrak Daun Sirih Merah (Piper crocatum Ruiz & Pav) sebagai Antihiperurisemia

2017 ◽  
Vol 15 (2) ◽  
pp. 216
Author(s):  
Dian Ratih Laksmitawati ◽  
Liliek Nurhidayati ◽  
Mochamad Futuchul Arifin ◽  
Bagus Bahtiar
Keyword(s):  
Chemical Properties ◽  
Ethanolic Extract ◽  
Ethanol Extract ◽  
Contour Plot ◽  
Pharmaceutical Dosage Form ◽  
Betel Leaf ◽  
Hot Air ◽  
Optimum Formula ◽  
Physical And Chemical

Ethanolic extract of red betel leaves (Piper crocatum Ruiz & Pav) has antihyperuricemic activity. In order to be applicable to consume, this extract need to be formulated into pharmaceutical dosage form. Granules which is packed in a tea sac bag was considered to be more practical andappropriate for person suff ering hyperuricemic, because they have to drink more water. In the granulation process, the he binder plays an important role so that this study aims to fi nd the optimal red betel leaf granule formula with variation on the extract dose and the polyvinyl pyrolidone (PVP) binder and prove granule activity in vivo in mouse hyperuricemia model. The extract was prepared by macerationthe leaves in 96% ethanol and sprayed dried by hot air. The powder was then formulated to granules form in 22 factorial design. The factors were the extract dosages (38% dan 47.51%) dan the amount of PVP (Polyvinyl Pyrrolidone) as a binder (0.5% dan 2%). The physical and chemical properties of the granules were evaluated, interaction dosage, PVP concentration and each properties was analysed by making the contour plot and superimposed contour plot to get the optimum formula. The in vivo antihyperuricemic activity of the granules was determined in hyperuricemic mice. The result showed that the optimum formula was found in granules that contained 42.5% extract and 1% PVP. At the equivalent dosage of 455 mg extract/kg, this granules formula had antihyperuricemic activity decreasing 54.2 %plasma uric acid level significantly. Thus it can be concluded that the optimum granules of ethanol extract of red betelleaf with 42.5% extra ct  content and 1% PVP proved to have antihiperurisemia activity in mice induced by chicken extractand potassium oxonate.

scholarly journals INHIBITORY EFFECT OF RED PIPER BETEL LEAF ETHANOL EXTRACT (PIPER CROCATUM RUIZ AND PAV.) AGAINST TRICHOMONAS VAGINALIS TROPHOZOITES IN VITRO

2017 ◽  
Vol 10 (11) ◽  
pp. 311
Author(s):  
Sri Agung Fitri Kusuma ◽  
Widyastuti S Manan ◽  
Fajar Budiman
Keyword(s):  
Trichomonas Vaginalis ◽  
Ethanol Extract ◽  
Inhibitory Effect ◽  
Betel Leaf ◽  
Extract Concentration ◽  
Standard Procedures ◽  
Vaginal Secretions ◽  
Piper Betel Leaf

  Objective: The objective of this study is to determine the minimum inhibitory concentration (MIC) of red betel leaf ethanol extract against Trichomonas vaginalis trophozoites.Materials and Methods: The samples of red piper betel leaf were extracted with 70% ethanol using a maceration method. The phytochemical screening of ethanol extract was performed using the standard procedures. Isolation of T. vaginalis trophozoites from vaginal secretions was conducted using swab method, then suspending it into a saline solution sterile and followed by observing trophozoites motility using a microscope. While the anti-leucorrhea activity test and determination of MIC extract was done using macrodillution method. The inhibitory effect of each extract concentration to trichomonas trophozoites’ morphology was observed under a microscope using staining techniques by adding Giemsa dyes.Results: The extract of red piper betel leaves contains several secondary metabolites such as alkaloids, flavonoids, polyphenols, quinones, and saponins. Of the six vaginal secretions, four positive trichomoniasis secretions were obtained. The results of anti-leucorrhea activity of red piper betel ethanol extract showed that the number of inactive trophozoites was proportional to the increasing of extract concentration. The inactive trophozoites were characterized by the absence of its motility under microscope observation. The MIC value of red piper betel extract of T. vaginalis trophozoites was 5% w/v.Conclusion: It can be concluded that the ethanol extract of red piper betel leaves could be contribute as a natural and safe anti-leucorrhea candidate for in vivo study on trichomoniasis in the future. 

Sign in / Sign up

Export Citation Format

Share Document