scholarly journals The Protective Effect of Interleukin-11 on the Cell Death Induced by X-ray Irradiation in Cultured Intestinal Epithelial Cell

2007 ◽  
Vol 48 (2) ◽  
pp. 171-177 ◽  
Author(s):  
Takashi UEMURA ◽  
Toshiyuki NAKAYAMA ◽  
Takafumi KUSABA ◽  
Yuichi YAKATA ◽  
Kazuyuki YAMAZUMI ◽  
...  
Keyword(s):  
Cell Death ◽  
Epithelial Cell ◽  
Protective Effect ◽  
Intestinal Epithelial Cell ◽  
Intestinal Epithelial ◽  
X Ray ◽  
Interleukin 11

Mechanisms of Bile Acid-Induced Intestinal Epithelial Cell Death

2014 ◽  
Vol 219 (3) ◽  
pp. S14-S15
Author(s):  
Anne S. Roberts ◽  
Stephanie C. Papillon ◽  
Avafia Y. Roberts ◽  
Mark R. Frey ◽  
Henri R. Ford ◽  
...  
Keyword(s):  
Cell Death ◽  
Bile Acid ◽  
Epithelial Cell ◽  
Intestinal Epithelial Cell ◽  
Intestinal Epithelial ◽  
Epithelial Cell Death

scholarly journals Tauroursodeoxycholic acid inhibits experimental colitis by preventing early intestinal epithelial cell death

2014 ◽  
Vol 94 (12) ◽  
pp. 1419-1430 ◽  
Author(s):  
Debby Laukens ◽  
Lindsey Devisscher ◽  
Lien Van den Bossche ◽  
Pieter Hindryckx ◽  
Roosmarijn E Vandenbroucke ◽  
...  
Keyword(s):  
Cell Death ◽  
Epithelial Cell ◽  
Intestinal Epithelial Cell ◽  
Experimental Colitis ◽  
Intestinal Epithelial ◽  
Tauroursodeoxycholic Acid ◽  
Epithelial Cell Death

Regulation of intestinal tyrosine phosphorylation and programmed cell death by peroxovanadate

1999 ◽  
Vol 277 (3) ◽  
pp. C572-C579 ◽  
Author(s):  
Lawrence A. Scheving ◽  
Jiji R. Thomas ◽  
Linda Zhang
Keyword(s):  
Cell Death ◽  
Epithelial Cell ◽  
Programmed Cell Death ◽  
Tyrosine Phosphorylation ◽  
Intestinal Epithelial Cell ◽  
Tyrosine Phosphatase ◽  
Active Form ◽  
Intestinal Epithelial ◽  
Protein Tyrosine Phosphorylation ◽  
Protein Tyrosine

Cell suspensions of ileal mucosa undergo a rapid and synchronized form of programmed cell death when cultured in a simple medium at 37°C. Because tyrosine phosphorylation of proteins plays a crucial role in the signal transduction of many cellular processes, we examined its role in intestinal programmed cell death by use of immunoblot and immunohistochemical methods. We observed a 50–70% reduction in tyrosine phosphorylation during the initial 10 min of intestinal epithelial cell culture. We hypothesized that the inhibition of protein tyrosine phosphatases would increase protein tyrosine phosphorylation in these suspensions and decrease programmed cell death. A strong inhibitor of these phosphatases (peroxovanadate) but not a weaker one (sodium orthovanadate) abolished the DNA fragmentation/laddering normally seen in dying enterocytes. Peroxovanadate enhanced protein tyrosine phosphorylation of many intestinal proteins, dramatically increasing the dually phosphorylated and active form of mitogen-activated protein kinase. Immunohistochemistry revealed a particularly high level of increased tyrosine phosphorylation in the intestinal crypts in peroxovanadate-treated mucosa. Kinetic studies indicated that the pivotal time for protein tyrosine phosphatase inhibition occurred within 5 min of ex vivo culture, precisely when protein tyrosine phosphorylation declined. Our data suggest that tyrosine kinase inactivation or tyrosine phosphatase activation may initiate intestinal epithelial cell death.

scholarly journals Autocrine IL-15 Mediates Intestinal Epithelial Cell Death Via the Activation of Neighboring Intraepithelial NK Cells

2002 ◽  
Vol 169 (11) ◽  
pp. 6187-6192 ◽  
Author(s):  
Naotoshi Kinoshita ◽  
Takachika Hiroi ◽  
Noriyuki Ohta ◽  
Satoshi Fukuyama ◽  
Eun Jeong Park ◽  
...  
Keyword(s):  
Cell Death ◽  
Epithelial Cell ◽  
Nk Cells ◽  
Intestinal Epithelial Cell ◽  
Intestinal Epithelial ◽  
Epithelial Cell Death

scholarly journals Fusobacterium nucleatum Promotes the Development of Ulcerative Colitis by Inducing the Autophagic Cell Death of Intestinal Epithelial

2020 ◽  
Vol 10 ◽  
Author(s):  
Wenhao Su ◽  
Yongyu Chen ◽  
Pan Cao ◽  
Yan Chen ◽  
Yuanmei Guo ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Cell Death ◽  
Epithelial Cell ◽  
Clinical Characteristics ◽  
Intestinal Epithelial Cell ◽  
Fusobacterium Nucleatum ◽  
Autophagic Cell Death ◽  
Intestinal Epithelial

There is a growing body of evidence which suggests that intestinal microbiota, especially Fusobacterium nucleatum (F. nucleatum), are associated with intestinal immune disease such as ulcerative colitis (UC). The mechanism by which F. nucleatum promotes intestinal epithelial cell (IEC) death remained undefined. Here, we investigated the potential mechanisms about how F. nucleatum aggravates IEC death in UC. We first detected the abundance of F. nucleatum in UC tissues and analyzed its relationship with the clinical characteristics of UC. Next, we explored whether F. nucleatum promotes intestinal epithelial cell death in vitro and in vivo. Furthermore, we extracted lipopolysaccharide (LPS) of the F. nucleatum and examined whether F. nucleatum exacerbates UC via LPS. Our results indicated that F. nucleatum was abundant in UC tissues and was correlated with clinical characteristics. In addition, we demonstrated that F. nucleatum and its LPS aggravated IEC death by promoted IEC autophagy. Furthermore, autophagy inhibitors, chloroquine (CQ), 3-methyladenine (3-MA) or Atg5 silencing prevented IEC death mediated by F. nucleatum, which suggests F. nucleatum may contribute to UC by activating autophagic cell death. All our results uncover a vital role of F. nucleatum in autophagic cell death and UC, giving rise to a new sight for UC therapy by inhibiting excessive IEC autophagy and autophagic cell death.

scholarly journals Ferroptosis involves in intestinal epithelial cell death in ulcerative colitis

2020 ◽  
Vol 11 (2) ◽  
Author(s):  
Minyi Xu ◽  
Jin Tao ◽  
Yidong Yang ◽  
Siwei Tan ◽  
Huiling Liu ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Cell Death ◽  
Epithelial Cell ◽  
Intestinal Epithelial Cell ◽  
Intestinal Epithelial ◽  
Epithelial Cell Death
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