"IN VIVO" MICROSCOPIC INSTRUMENTATION AND ANALYSIS OF LASER-TISSUE INTERACTION IN A SKIN FLAP MODEL

1990 ◽  
Author(s):  
ΖΑΦΕΙΡΙΟΣ ΓΟΥΡΓΟΥΛΙΑΤΟΣ
Keyword(s):  
Skin Flap ◽  
Tissue Interaction ◽  
Laser Tissue Interaction

Microscopic Instrumentation and Analysis of Laser-Tissue Interaction in a Skin Flap Model

1991 ◽  
Vol 113 (3) ◽  
pp. 301-307 ◽  
Author(s):  
Z. F. Gourgouliatos ◽  
A. J. Welch ◽  
K. R. Diller
Keyword(s):  
Skin Flap ◽  
Light Attenuation ◽  
Argon Laser ◽  
Dye Laser ◽  
In Vivo Studies ◽  
Tissue Interaction ◽  
Experimental Apparatus ◽  
Laser Tissue Interaction ◽  
Unique Method

A dorsal skin flap model for microcirculatory studies has been modified for “in vivo” studies of laser-tissue interaction with microcirculation. An experimental apparatus has been built implementing a laser delivery system, video microscopy during irradiation, and thermal recordings. This model has been used to study irradiation effects on microcirculation using the argon laser (488 and 514.5 nm) and the argon pumped dye laser at 577 nm. The results include: measurements of the optical properties of the model; dosimetry measurements for the production of embolized and stationary coaguli in arterioles and venules; and focal vessel disappearance of venules irradiated with the argon or the argon pumped dye laser at 577 nm; a method to determine light attenuation in the model; a unique method for measurements of blood flow velocity in arterioles and venules and measurements obtained with this method; measurements of transient and steady state temperatures during irradiation and a study of laser induced photorelaxation phenomena in venules.

Experimental in-vivo study of laser-tissue interaction on the brain: influence of gaseous environment

1990 ◽  
Author(s):  
Maria C. Chavantes ◽  
Lucia J. Zamorano ◽  
Federico Vinas ◽  
Manuel Dujovny ◽  
Ljubisa Dragovic
Keyword(s):  
In Vivo Study ◽  
Tissue Interaction ◽  
Gaseous Environment ◽  
Laser Tissue Interaction ◽  
The Brain

Basic laser tissue interaction

1989 ◽  
Vol 4 (S1) ◽  
pp. 7-15 ◽  
Author(s):  
G. Müller ◽  
B. Schaldach
Keyword(s):  
Tissue Interaction ◽  
Laser Tissue Interaction

Cryo, Hyper or Both? Investigating Combination Cryo/Hyperthermia in the Dorsal Skin Flap Chamber

2000 ◽  
Author(s):  
Nathan E. Hoffmann ◽  
Bo H. Chao ◽  
John C. Bischof
Keyword(s):  
Combination Therapy ◽  
Thermal History ◽  
Standard Treatment ◽  
Tissue Injury ◽  
Skin Flap ◽  
Dorsal Skin ◽  
Combination Therapies ◽  
Disease Treatment ◽  
Copenhagen Rat

Abstract Combination therapies have been investigated as a mean to increase efficacy of disease treatment. For example, combinations such as radiation and chemotherapy, surgery and chemotherapy, and two different chemotherapies have become standard treatment for most cancers. Current theories suggest that vascular-mediated injury is an important mechanism of cryosurgical (reviewed in Gage and Baust (1998)) and hyperthermic destruction (Badylak et al., 1985; Dudar and Jain, 1984) in the treatment of solid tumors. These techniques appear complementary. Freezing creates vascular damage and promotes stasis within the vessels (Rabb et al., 1974), whereas hyperthermia creates cell and vascular destruction more effectively with a compromised vasculature (Shakil et al., 1999). Thus, in this study, we investigated the effect of combining these therapies on the vascular and tissue injury from the two therapies. We chose the dorsal skin flap chamber (DSFC) implanted in the Copenhagen rat as the cryosurgical model for this study. This in vivo freezing model allowed us to monitor thermal history and investigate both vascular and tissue injury in response to the combination therapy.

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