Microscopic Instrumentation and Analysis of Laser-Tissue Interaction in a Skin Flap Model

1991 ◽  
Vol 113 (3) ◽  
pp. 301-307 ◽  
Author(s):  
Z. F. Gourgouliatos ◽  
A. J. Welch ◽  
K. R. Diller
Keyword(s):  
Skin Flap ◽  
Light Attenuation ◽  
Argon Laser ◽  
Dye Laser ◽  
In Vivo Studies ◽  
Tissue Interaction ◽  
Experimental Apparatus ◽  
Laser Tissue Interaction ◽  
Unique Method

A dorsal skin flap model for microcirculatory studies has been modified for “in vivo” studies of laser-tissue interaction with microcirculation. An experimental apparatus has been built implementing a laser delivery system, video microscopy during irradiation, and thermal recordings. This model has been used to study irradiation effects on microcirculation using the argon laser (488 and 514.5 nm) and the argon pumped dye laser at 577 nm. The results include: measurements of the optical properties of the model; dosimetry measurements for the production of embolized and stationary coaguli in arterioles and venules; and focal vessel disappearance of venules irradiated with the argon or the argon pumped dye laser at 577 nm; a method to determine light attenuation in the model; a unique method for measurements of blood flow velocity in arterioles and venules and measurements obtained with this method; measurements of transient and steady state temperatures during irradiation and a study of laser induced photorelaxation phenomena in venules.

Experimental in-vivo study of laser-tissue interaction on the brain: influence of gaseous environment

1990 ◽  
Author(s):  
Maria C. Chavantes ◽  
Lucia J. Zamorano ◽  
Federico Vinas ◽  
Manuel Dujovny ◽  
Ljubisa Dragovic
Keyword(s):  
In Vivo Study ◽  
Tissue Interaction ◽  
Gaseous Environment ◽  
Laser Tissue Interaction ◽  
The Brain

Measurements of argon laser light attenuation in the skin 'in vivo' using a unique animal model

2003 ◽  
Author(s):  
Z.F. Gourgouliatos ◽  
S. Ghaffari ◽  
A.J. Welch ◽  
K.R. Diller ◽  
R.C. Straight
Keyword(s):  
Animal Model ◽  
Laser Light ◽  
Light Attenuation ◽  
Argon Laser

Measurements of argon laser light attenuation in the skin ‘in vivo’ using a unique animal model

1992 ◽  
Vol 7 (1-4) ◽  
pp. 63-71 ◽  
Author(s):  
Zafirios F. Gourgouliatos ◽  
Ashley J. Welch ◽  
Kenneth R. Diller
Keyword(s):  
Animal Model ◽  
Laser Light ◽  
Light Attenuation ◽  
Argon Laser

In vitro and in vivo studies of new cationic Zn(II)‐benzonaphthoporphyrazines as photosensitizers for PDT

2001 ◽  
Vol 5 (8) ◽  
pp. 645-651
Author(s):  
M. Peeva ◽  
M. Shopova ◽  
U. Michelsen ◽  
D. Wöhrle ◽  
G. Petrov ◽  
...  
Keyword(s):  
In Vivo Studies

Effect of caffeine on theophyliine on cerebral blood flow response to brain activation: In vitro and in vivo studies

2005 ◽  
Vol 25 (1_suppl) ◽  
pp. S198-S198
Author(s):  
Joseph R Meno ◽  
Thien-son K Nguyen ◽  
Elise M Jensen ◽  
G Alexander West ◽  
Leonid Groysman ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Brain Activation ◽  
In Vivo Studies ◽  
Blood Flow Response ◽  
Flow Response

Effects of Unfractionated and Low Molecular Weight Heparins on Platelet Thromboxane Biosynthesis “In Vivo”

1994 ◽  
Vol 72 (06) ◽  
pp. 942-946 ◽  
Author(s):  
Raffaele Landolfi ◽  
Erica De Candia ◽  
Bianca Rocca ◽  
Giovanni Ciabattoni ◽  
Armando Antinori ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Unfractionated Heparin ◽  
Low Molecular Weight Heparin ◽  
Primary Source ◽  
In Vivo Studies ◽  
Low Molecular Weight ◽  
Heparin Administration ◽  
To Receive

SummarySeveral “in vitro” and “in vivo” studies indicate that heparin administration may affect platelet function. In this study we investigated the effects of prophylactic heparin on thromboxane (Tx)A2 biosynthesis “in vivo”, as assessed by the urinary excretion of major enzymatic metabolites 11-dehydro-TxB2 and 2,3-dinor-TxB2. Twenty-four patients who were candidates for cholecystectomy because of uncomplicated lithiasis were randomly assigned to receive placebo, unfractionated heparin, low molecular weight heparin or unfractionaed heparin plus 100 mg aspirin. Measurements of daily excretion of Tx metabolites were performed before and during the treatment. In the groups assigned to placebo and to low molecular weight heparin there was no statistically significant modification of Tx metabolite excretion while patients receiving unfractionated heparin had a significant increase of both metabolites (11-dehydro-TxB2: 3844 ± 1388 vs 2092 ±777, p <0.05; 2,3-dinor-TxB2: 2737 ± 808 vs 1535 ± 771 pg/mg creatinine, p <0.05). In patients randomized to receive low-dose aspirin plus unfractionated heparin the excretion of the two metabolites was largely suppressed thus suggesting that platelets are the primary source of enhanced thromboxane biosynthesis associated with heparin administration. These data indicate that unfractionated heparin causes platelet activation “in vivo” and suggest that the use of low molecular weight heparin may avoid this complication.

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