scholarly journals Ποιότητα ζωής των ασθενών μετά από ολική λαρυγγεκτομή

2017 ◽  
Author(s):  
Γιάννης Θρασυβούλου
Keyword(s):  
Quality Of Life ◽  
Life Questionnaire ◽  
Cross Sectional ◽  
Quality Of Life Questionnaire ◽  
Md Anderson ◽  
Anderson Dysphagia Inventory

Η παρούσα μελέτη έχει σκοπό να συγκρίνει την οριζόντια και την κάθετη μέθοδο σύγκλισης του νεοφάρυγγα μετά από ολική λαρυγεκτομή όσον αφορά την καταποτική λειτουργία των ασθενών, και την κατάποση σε σχέση με την ποιότητα ζωής. Η πιθανή επίδραση άλλων θεραπειών και της ηλικίας εξετάστηκε επίσης. Διενεργήθηκε cross – sectional μελέτη σε 52 ασθενείς με ολική λαρυγγεκτομή. Σε όλους τους ασθενείς διανεμήθηκαν ερωτηματολόγια δυσφαγίας (MD Anderson Dysphagia Inventory) και ποιότητας ζωής (MD Anderson Quality of life Questionnaire). Για σύγκριση μεταξύ των ομάδων χρησιμοποιήθηκαν οι μη παραμετρικές δοκιμασίες Mann-Whitney και ο δείκτης κατάταξης Spearman’s. Άλλες παράμετροι όπως πρωτογενής λαρυγγεκτομή (χωρίς άλλη θεραπεία), λαρυγγεκτομή ως θεραπεία διάσωσης και λαρυγγεκτομή ακολουθούμενη από χημειοακτινοθεραπεία εξετάστηκαν με την μέθοδο Kruskal-Wallis. Χρησιμοποιήθηκαν πολλαπλή γραμμική παλινδρόμηση για να εξεταστεί η συμβολή της ομιλίας και της κατάποσης μετά την λαρυγγεκτομή, στην ποιότητα ζωής. Τα ερωτηματολόγια συμπληρώθηκαν από 34 ασθενείς; 31 άρρενες και 3 γυναίκες. Η μέση ηλικία ήταν 66.8 έτη. Οι 16 ασθενείς είχαν οριζόντια σύγκλιση του νεοφάρυγγα και οι 18 κάθετη σύγκλιση του νεοφάρυγγα. Ο δείκτης ποιότητας ζωής ήταν 91,5 (+12.5) στους ασθενείς με οριζόντια σύγκλιση και 68.3 (+18.4) στους ασθενείς με κάθετη σύγκλιση. Η τιμή του δείκτη ποιότητας ζωής ήταν 81.1 (11.67) για την οριζόντια και 80.78 (12.13) για την ομάδα της κάθετης συρραφής. Ο συντελεστής συσχέτισης ήταν θετικός και στις δύο ομάδες ασθενών, αλλά ήταν αυξημένος στην ομάδα της οριζόντιας συρραφής. Η ποιότητα ζωής και ο δείκτης δυσφαγίας δεν επηρεάστηκαν από επικουρικές θεραπείες αλλά ούτε από την ηλικία. Η οριζόντια σύγκλιση σε σύγκριση με την κάθετη σύγκλιση του νεοφάρυγγα οδηγεί σε βελτιωμένη μετεγχειρητική κατάποση – ποιότητα ζωής. Οι επικουρικές θεραπείες και η ηλικία δεν επηρεάζουν την κατάποση ή την ποιότητα ζωής. Οι ωτορινολαρυγγολόγοι πρέπει να επιλέγουν την κατάλληλη μέθοδο σύγκλισης του νεοφάρυγγα για τα βέλτιστα αποτελέσματα της κατάποσης.

scholarly journals Determination of the Influence of Peripheral Neuropathy Symptoms on Quality of Life in Breast Cancer Patients Receiving Paclitaxel: Prospective Cross Sectional Study With Four Follow-ups

2021 ◽  
Author(s):  
BERNA KURT ◽  
ZEYNEP SİPAHİ KARSLI ◽  
BERNA ÖMÜR ÇAKMAK ÖKSÜZOĞLU ◽  
EMİNE ÖZTÜRK ◽  
NESLİHAN DEMİRÖRS ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Quality Of Life ◽  
Peripheral Neuropathy ◽  
Assessment Tool ◽  
Life Questionnaire ◽  
Breast Cancer Patients ◽  
Cross Sectional ◽  
Quality Of Life Questionnaire

Abstract Background The objective of this study is to evaluate the impact of peripheral neuropathy on the quality of life of breast cancer patients throughout with monthly follow-up during 4 months of paclitaxel treatment.Material and methods The research was conducted with a prospective cross sectional with four follow-ups descriptive design. The study population consisted of female patients with breast cancer at Ankara Oncology Training and Research Hospital between August 2018 and January 2019. Data were collected the ‘’Patient Information Form’’,‘’EORTC C30 Cancer Quality Of Life Questionnaire’’ and ‘’Chemotherapy-Induced Peripheral Neuropathy Assessment Tool’’. The study was undertaken in accordance with the STROBE checklist for cross-sectional studies. Results Of 79 patients included in the Chemotherapy-Induced Peripheral Neuropathy Assessment Tool except for the general activity subdimension were statistically significant in the ratings of 2nd, compared to 1st; 3rd compared to 1st and 2nd; 4th compared to 1st, 2nd, and 3rd follow-up periods. The overall mean of EORTC C30 Cancer Quality of Life Questionnaire, functional subdimension, symptom severity, and general well-being in the evaluations of 2nd, compared with 1st; 3rd compared with 1st and 2nd; 4th compared with 1st, 2nd, and 3rd follow-up periods it was found that the mean values of symptom that decreased gradually were statistically significant.Conclusion The neuropathy scale was found to be higher in 2nd, 3rd, 4th follow-up periods than in 1st follow-up. Also, EORTC C30 Cancer QLQ subdimensions were high initially but gradually decreased after the fourth cycle. Thus, it was found that the increase in neuropathy symptoms negatively affects the quality of life.

scholarly journals Funktionelle Ergebnisse nach transmandibulärer Resektion und primärer Radiochemotherapie bei fortgeschrittenen Kopf-Hals-Plattenepithelkarzinomen

HNO ◽  
2020 ◽  
Author(s):  
A. Knopf ◽  
N. Mansour ◽  
B. Hofauer ◽  
F. Johnson ◽  
H. Bier ◽  
...  
Keyword(s):  
Visuelle Analogskala ◽  
Life Questionnaire ◽  
Funktionelle Ergebnisse ◽  
European Organization ◽  
Quality Of Life Questionnaire ◽  
Mallampati Score ◽  
Saxon Test ◽  
Md Anderson ◽  
Anderson Dysphagia Inventory

Zusammenfassung Ziel der Arbeit In dieser Studie wurden die funktionellen Ergebnisse nach transmandibulärer Resektion und Rekonstruktion mittels mikrovaskulär anastomosiertem Radialistransplantat (TMR+Tx) gegenüber einer primären Radiochemotherapie (pRCT) bei fortgeschrittenen orophayngealen Plattenepithelkarzinomen (OPSCC) verglichen. Methoden Es erfolgte ein Vergleich zwischen 50 OPSCC-Patienten mit TMR+Tx und 50 OPSCC-Patienten mit pRCT. Die Wasserschluckzeit war als primärer Endpunkt definiert. Der Saxon-Test, die maxillomandibuläre Distanz, der Mallampati-Score, der Quotient aus Körpergröße zu Gewicht, eine nasale Penetration, das Vorhandensein einer Ernährungssonde/Tracheostomie sowie 4 validierte Fragebögen (Visuelle Analogskala zur Mundtrockenheit, Sicca VAS; MD Anderson Dysphagia Inventory, MDADI; Voice Handicap Index, VHI; European Organization for Research and Treatment of Cancer Quality of Life Questionnaire – Head and Neck Cancer – 35 Items, QLQ-H&N35) dienten als sonstige Endpunkte zur Beurteilung der Funktion und Lebensqualität. Ergebnisse Die Gesamtkohorte an operierten Patienten zeigte eine erhöhte Rate an nasaler Penetration (p < 0,0001), was mit einer verlängerten Wasserschluckzeit verbunden war (p < 0,05). Durch eine modifizierte Rekonstruktion des Weichgaumens wurde die nasale Penetration in der chirurgisch therapierten Gruppe im Vergleich zur klassischen Rekonstruktion signifikant reduziert (p = 0,0001). Patienten mit pRCT litten signifikant stärker an einer Xerostomie (Saxon-Test) als Patienten nach TMR+Tx und Adjuvanz (p = 0,001). In den Fragebögen zur Funktionalität und Lebensqualität zeigte sich kein Unterschied zwischen den Gruppen. Schussfolgerung Die TMR+Tx mit modifizierter Rekonstruktion und adjuvante Therapie zeigte gegenüber der pRCT vergleichbare funktionelle Ergebnisse.

scholarly journals The McGill Quality of Life Questionnaire-Revised (MQOL-R). Psychometric properties and validation of a Brazilian version on palliative care patients: a cross-sectional study

2020 ◽  
Vol 18 (1) ◽  
Author(s):  
Paul Vicuña Serrano ◽  
Gerardo Beltran Serrano ◽  
Iraci L. S. Torres ◽  
Roberta Rossi Graudner ◽  
Wolnei Caumo
Keyword(s):  
Quality Of Life ◽  
Palliative Care ◽  
Psychometric Properties ◽  
Convergent Validity ◽  
Karnofsky Performance Scale ◽  
Life Questionnaire ◽  
Cross Sectional ◽  
Quality Of Life Questionnaire ◽  
Validity Criterion

Abstract Background To assess the psychometric properties, including internal consistency, construct validity, criterion validity, criterion-group validity, and responsiveness, the Reviewed McGill Quality of Life Questionnaire (MQOL-R), into Brazilian Portuguese-(BrP). Also, to analyze the relationship of the BrP-MQOL-R with the scores on the Karnofsky Performance Scale (KPS) and on the Numerical Pain Scale (NPS 0–10). Methods The BrP-MQOL-R was administered to a sample of 146 adults (men = 78). A team of experts translated the MQOL-R according to international guidelines. Convergent validity and Confirmatory factor analysis (CFA) was performed. Results The BrP-MQOL-R Cronbach’s alpha was 0.85. CFA supported the original four-factor structure, with the following revised model fit-indices: PCLOSE = 0.131, Tucker-Lewis Index (TLI) rho 2 = 0.918, incremental fit index (IFI) delta 2 = 0.936. The convergence validity is supported by a significant correlation between BrP-MQOL-R total scores and their subscales with KPS and with the single item related to the quality of life. And by a converse correlation with the pain scores in the NPS (0–10). Receiver operator characteristics (ROC) analysis showed subjects with KPS equal to or lower than 30% could be discriminated from those with scores on KPS higher than 30% by an area under the curve (AUC) = 0.71, sensitivity = 97%, and specificity = 92%). Conclusion The BrP-MQOL-R proves to be a reliable instrument for assessing the quality of life (QOL) in palliative care (PC), with primary evidence of validity. BrP-MQOL-R presented adequate discriminate properties to identify distinct conditions that impact the QOL in PC.

scholarly journals Quality of Life (QOL) in Patients with Acromegaly Is Severely Impaired: Use of a Novel Measure of QOL: Acromegaly Quality of Life Questionnaire

2005 ◽  
Vol 90 (6) ◽  
pp. 3337-3341 ◽  
Author(s):  
Susannah V. Rowles ◽  
L. Prieto ◽  
X. Badia ◽  
Steven M. Shalet ◽  
Susan M. Webb ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Signs And Symptoms ◽  
Well Being ◽  
Cross Sectional Study ◽  
Life Questionnaire ◽  
Cross Sectional ◽  
Quality Of Life Questionnaire ◽  
Utility Index ◽  
Igf I

Acromegaly Quality of Life Questionnaire (AcroQoL) is a new disease-generated quality of life (QOL) questionnaire comprising 22 questions covering physical and psychological aspects of acromegaly and subdivided into “appearance” and “personal relations” categories. We have performed a cross-sectional study of QOL in 80 patients [43 male (mean age, 54.2 yr; range, 20–84); median GH, 0.93ng/ml (range, &lt;0.3 to 23.7); IGF-I, 333.1 ng/ml (range, 47.7–899)] with acromegaly. In addition to AcroQoL, patients completed three generic QOL questionnaires: Psychological General Well-Being Schedule (PGWBS), EuroQol, and a signs and symptoms score (SSS). All three generic questionnaires confirmed impairment in QOL [mean scores: PGWBS, 69.6; EuroQol, visual analog scale, 66.4 (range, 20–100) and utility index, 0.7 (range, −0.07 to 0.92); and SSS, 12 (range, 0–27)]. There was no correlation between biochemical control and any measure of QOL. AcroQoL (57.3%; range, 18.2–93.2) correlated with PGWBS (r = 0.73; P &lt; 0.0001); and in patients with active disease, AcroQoL-physical dimension correlated with SSS (r = −0.67; P &lt; 0.0003). In all questionnaires, prior radiotherapy was associated with impaired QOL. In conclusion, these data underline the marked impact that acromegaly has on patients’ QOL and provide the first evidence validating AcroQoL against well-authenticated measures of QOL. This indicates the potential of AcroQoL as a patient-friendly measure of disease activity.

Psychological manifestation in adolescents with thalassemia

2011 ◽  
Vol 26 (S2) ◽  
pp. 276-276
Author(s):  
H. Dessoki ◽  
T. Elhifnawy ◽  
O. Ezzat
Keyword(s):  
Quality Of Life ◽  
Outpatient Clinic ◽  
Depression Scale ◽  
Structured Interview ◽  
Life Questionnaire ◽  
Cross Sectional ◽  
Quality Of Life Questionnaire ◽  
Middlesex Hospital ◽  
Significant Difference

Objectiveβ-thalassemia major and its complications carry a significant psychological impact, causing emotional burden, hopelessness, and difficulty with social integration.MethodCross-sectional study which includes thirty adolescents with diagnosis of thalassemia & another group of thirty adolescents from gastrointestinal outpatient clinic were selected. All participants were subjected to Semi structured interview, Patient Health Questionnaire, Hospital Anxiety Depression Scale, Middlesex Hospital Questionnaire, and McGill Quality of Life Questionnaire.ResultsThalassemic adolescents shows statistically significant higher depression (p < 0.001), and higher anxiety (p < 0.001) compared to adolescents from gastrointestinal outpatient clinic. There was highly statistical significant difference regarding Middlesex Hospital Questionnaire (p < 0.001), and McGill Quality of Life Questionnaire. (p < 0.001).ConclusionDepressive and anxiety disorders were more prevalent among adolescents with thalassemia. Also, among the same group there was higher degree of Free Floating Anxiety, Phobic Anxiety, Obsessive Symptoms, Somatic Symptoms, Depressive Symptoms, and hysteria. Quality of life was highly affected among adolescents with thalassemia.

scholarly journals Penilaian kualitas hidup penderita karsinoma nasofaring berdasarkan Karnofsky Scale, EORTC QLQ-C30 dan EORTC QLQ-H & N35

2014 ◽  
Vol 43 (2) ◽  
pp. 110
Author(s):  
Dewi Kurniawati ◽  
Frederik George Kuhuwael ◽  
Abdul Qadar Punagi
Keyword(s):  
Quality Of Life ◽  
Karnofsky Performance Scale ◽  
Life Questionnaire ◽  
Cross Sectional ◽  
European Organization ◽  
Quality Of Life Questionnaire ◽  
Eortc Qlq C30 ◽  
Eortc Qlq ◽  
Performance Scale

Latar belakang: Karsinoma nasofaring (KNF) berpengaruh terhadap kualitas hidup penderita, baik dari kankernya sendiri, maupun pengobatan serta efek sampingnya. Penilaian kualitas hidup penderita KNF dapat secara unidimensional menggunakan parameter status tampilan Karnofsky Performance Scale (Karnofsky PS) atau multidimensional memakai parameter European Organization For Research and Treatment of Cancer Quality of Life Questionnaire C30 (EORTC QLQ-C30) dan European Organization For Research And Treatment Of Cancer Head and Neck Cancer Quality of Life Questionnaire (EORTC QLQ-H&N35).Tujuan: Menilai kesesuaian hasil skor Karnofsky PS, EORTC QLQ-C30 dan EORTC QLQ-H&N35 dalam menilai kualitas hidup penderita KNF dengan menentukan korelasi antar parameter dan menentukan estimasi skor Karnofsky PS menggunakan skor EORTC QLQ-C30 dan skor EORTC QLQ-H&N35. Menganalisis hubungan antar parameter menurut stadium.Metode: Penelitian adalah observasional analitik dengan pedekatan cross sectional. Populasinya semua kasus KNF yang berobat ke Bagian THT-KL, Rumah Sakit Wahidin Sudirohusodo, Makassar. Sampel sebanyak 48 orang dipilih secara purposive. Penilaian kualitas hidup menggunakan parameter Karnofsky PS, EORTC QLQ-C30 dan EORTC QLQ-H&N35. Hasil: Didapati kesesuaian hasil skor dari ketiga parameter, ditandai adanya korelasi bermakna antara skor Karnofsky PS, skor EORTC QLQ-C30 dan skor EORTC QLQ-H&N35. Semakin tinggi skor Karnofsky PS, akan semakin rendah skor EORTC QLQ-C30 dan skor EORTC QLQ-H&N35 maka kualitas hidup penderita KNF semakin baik. Skor EORTC QLQ-C30 dan skor EORTC QLQ-H&N35 dapat mengestimasi skor Karnofsky PS. Terdapat hubungan bermakna antara Karnofsky PS, EORTC QLQ-C30 dan EORTC QLQ-H&N35 menurut stadium (p<0,05). Kesimpulan: DEORTC QLQ-C30 dan EORTC QLQ-H&N35 dapat melengkapi Karnofsky PS dalam penilaian kualitas hidup penderita kanker kepala leher terutama KNF. Kata kunci: Kualitas hidup, KNF, Karnofsky PS, EORTC QLQ-C30, EORTC QLQ-H&N3.

scholarly journals Sense of Coherence and Quality of Life in Patients Treated with Antivitamin K Oral Anticoagulants: A Cross-Sectional Study

2021 ◽  
Vol 18 (4) ◽  
pp. 1668
Author(s):  
Ana Anguas-Gracia ◽  
Ana Belén Subirón-Valera ◽  
Beatriz Rodríguez-Roca ◽  
Ángel Gasch-Gallén ◽  
Isabel Antón-Solanas ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Sense Of Coherence ◽  
Oral Anticoagulants ◽  
Self Management ◽  
Life Questionnaire ◽  
Anticoagulant Treatment ◽  
Oral Anticoagulant Treatment ◽  
Cross Sectional ◽  
Quality Of Life Questionnaire

The aim of this study was to analyze the correlation between the participants’ self-reported quality of life and their sense of coherence in a sample (n = 85) of patients on treatment with oral antivitamin K anticoagulants. A cross-sectional design was used. The measurement instruments included a questionnaire on sociodemographic variables, the Spanish version of the Abbreviated World Health Organization Quality of Life questionnaire (WHOQOL-BREF), an oral-anticoagulant-treatment-specific quality-of-life questionnaire, and the sense-of-coherence (SOC) scale. We analyzed the correlations between the participants’ characteristics and the results from the quality-of-life and SOC scales. Age, level of education, employment status, living arrangement, and treatment length were the determinants of the quality of life in people treated with oral anticoagulants. We found a significant association between the four domains of the WHOQOL-BREF questionnaire and general treatment satisfaction (p < 0.01); no significant correlations were found between the SOC subscales and the oral-anticoagulant-treatment-specific quality of life in our sample. Women had a worse level of self-management than men. Nursing interventions should be tailored to the needs of the populations on treatment with oral anticoagulants in order to facilitate a higher level of self-management.

scholarly journals The McGill Quality of Life Questionnaire-Revised (MQOL-R). Psychometric properties and validation of a Brazilian version on palliative care patients: A Cross-sectional Study

2020 ◽  
Author(s):  
Paul Vicuña Serrano ◽  
Gerardo Beltran Serrano ◽  
Iraci Lucena da Silva Torres ◽  
Roberta Rossi Graudner ◽  
Wolne Caumo ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Palliative Care ◽  
Psychometric Properties ◽  
Convergent Validity ◽  
Karnofsky Performance Scale ◽  
Life Questionnaire ◽  
Cross Sectional ◽  
Quality Of Life Questionnaire ◽  
Validity Criterion

Abstract Background: To assess the psychometric properties, including internal consistency, construct validity, criterion validity, criterion-group validity, and responsiveness, the Reviewed McGill Quality of Life Questionnaire (MQOL-R), into Brazilian Portuguese-(BrP). Also, to analyze the relationship of the BrP-MQOL-R with the scores on the Karnofsky Performance Scale (KPS) and on the Numerical Pain Scale (NPS 0-10).Methods: The BrP-MQOL-R was administered to a sample of 146 adults (men = 78). A team of experts translated the MQOL-R according to international guidelines. Convergent validity and Confirmatory factor analysis (CFA) was performed. Results: The BrP-MQOL-R Cronbach´s alfa was 0.85. CFA supported the original four-factor structure, with the following revised model fit-indices: PCLOSE = 0.131, Tucker-Lewis Index (TLI) rho2= 0.918, incremental fit index (IFI) delta 2 = 0.936. The convergence validity is supported by a significant correlation between BrP-MQOL-R total scores and their subscales with KPS and with the single item related to the quality of life. And by a converse correlation with the pain scores in the NPS (0-10). Receiver operator characteristics (ROC) analysis showed subjects with KPS equal to or lower than 30% could be discriminated from those with scores on KPS higher than 30% by an area under the curve (AUC) = 0.71, sensitivity = 97%, and specificity = 92%). Conclusion: The BrP-MQOL-R proves to be a reliable instrument for assessing the quality of life (QOL) in palliative care (PC), with primary evidence of validity. BrP-MQOL-R presented adequate discriminate properties to identify distinct conditions that impact the QOL in PC.

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