scholarly journals Research Progress of the Effects of Traditional Chinese Medicine and Its Active Ingredients on the Blood Brain Barrier

2013 ◽  
Vol 02 (02) ◽  
pp. 12-18
Author(s):  
泉琳 顾
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Research Progress ◽  
Active Ingredients ◽  
Blood Brain

scholarly journals The Traditional Chinese Medicine Compound, GRS, Alleviates Blood–Brain Barrier Dysfunction

2020 ◽  
Vol Volume 14 ◽  
pp. 933-947
Author(s):  
Yuanyuan Zhang ◽  
Yang Hu ◽  
Min Li ◽  
Jieman Wang ◽  
Gengshuo Guo ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Barrier Dysfunction ◽  
Blood Brain

Research progress of mechanisms for tight junction damage on blood–brain barrier inflammation

2020 ◽  
pp. 1-12 ◽  
Author(s):  
Bo Zhao ◽  
Qiyang Yin ◽  
Yuxiang Fei ◽  
Jianping Zhu ◽  
Yanying Qiu ◽  
...  
Keyword(s):  
Tight Junction ◽  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Research Progress ◽  
Blood Brain

scholarly journals RADT-46. SYSTEMATIC REVIEW OF RADIOSENSITIZERS FOR MALIGNANT BRAIN TUMORS: POTENTIAL FOR LEARNING FROM PAST FAILURES

2020 ◽  
Vol 22 (Supplement_2) ◽  
pp. ii191-ii191
Author(s):  
Usman Beg ◽  
Brianna Snyder ◽  
Sarosh Madhani ◽  
Nima Hamidi ◽  
Alireza Mansouri
Keyword(s):  
Systematic Review ◽  
Brain Tumors ◽  
Blood Brain Barrier ◽  
Mechanism Of Action ◽  
Progression Free Survival ◽  
Tumor Oxygenation ◽  
Cns Tumors ◽  
Brain Barrier ◽  
Research Progress ◽  
Blood Brain

Abstract INTRODUCTION Radiation therapy (RT) is the cornerstone of management of malignant CNS tumors but its efficacy is limited in hypoxic tumors. Although numerous radiosensitizer compounds have been developed to enhance the effect of RT, progress has been stagnant. Through this systematic review of the literature on radiosensitizers for malignant CNS tumors, we have sought to provide an overview of radiosensitizers developed to date, summarize their safety and efficacy, and evaluate areas for possible improvement. METHODS PUBMED, EMBASE, Cochrane, and Web of Science were searched using terminology pertaining to radiosensitizers for brain tumor RT according to PRISMA guidelines. Publications reporting clinical evidence of non-antineoplastic radiosensitizers with RT for malignant CNS tumors were included. Pre-specified variables were extracted. Outcomes of interest were overall survival, progression-free survival, adverse events, and quality-of-life outcomes. RESULTS Forty-eight publications were identified which included 20 unique non-antineoplastic radiosensitizing agents. Only 2/20 agents, fluosol with oxygen, and efaproxiral, showed improvement in outcomes in patients with glioblastoma and brain metastasis, respectively. A larger study was not able to confirm the latter. While molecular similarities between these two agents were not identifiable, the effective mechanism of action allowed them to modulate hypoxia from within blood vessels, without crossing blood-brain barrier. Nine agents required dose modification, change of schedule, or complete discontinuation due to toxicities. CONCLUSION Despite decades of research, progress in the field of radiosensitizers for malignant CNS tumors has been limited. Available data demonstrates the lack of progress in identifying effective radiosensitizers for brain tumors. Of the many non-antineoplastic radiosensitizers that have been tested, only two have showed (limited) efficacy by targeting tumor oxygenation. Alternative strategies such as synthetic drug design, based on a mechanism of action that is independent of crossing the blood-brain barrier, may be necessary. Such studies are currently underway.

Conformationally Constrained Peptide Drugs Targeted at the Blood-Brain Barrier

1995 ◽  
Author(s):  
Thomas P. Davis ◽  
Thomas J. Abbruscato ◽  
Elizabeth Brownson ◽  
Victor J. Hruby
Keyword(s):  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Peptide Drugs ◽  
Conformationally Constrained ◽  
Blood Brain
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