Numerical Simulation of Aqueous Humor Flow in Glaucoma

苗 王

doi:10.12677/mos.2020.93027

Numerical simulation of the aqueous humor flow in the eye drainage system; a healthy and pathological condition comparison.

Medical Engineering & Physics ◽

10.1016/j.medengphy.2020.07.010 ◽

2020 ◽

Vol 83 ◽

pp. 82-92 ◽

Cited By ~ 1

Author(s):

G.J. Martínez Sánchez ◽

C. Escobar del Pozo ◽

J.A. Rocha Medina ◽

J. Naude ◽

A. Brambila Solorzano

Keyword(s):

Numerical Simulation ◽

Aqueous Humor ◽

Pathological Condition ◽

Drainage System ◽

Aqueous Humor Flow ◽

System A

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Numerical Simulation of Multi-Field Coupling in Aqueous Humor Under the Condition of Dynamic Pressure

International Journal of Computational Methods ◽

10.1142/s021987621842001x ◽

2019 ◽

Vol 16 (03) ◽

pp. 1842001 ◽

Cited By ~ 2

Author(s):

Hongfang Song ◽

Lin Li ◽

Wenjia Wang ◽

Qi Li ◽

Zhicheng Liu

Keyword(s):

Numerical Simulation ◽

Aqueous Humor ◽

Dynamic Pressure ◽

Field Coupling ◽

Rabbit Eye ◽

Aqueous Humor Flow ◽

Simulation Based ◽

Dynamic Pressure Measurement ◽

Ocular Pressure ◽

Fluid Solid Interaction

In order to investigate the aqueous humor flow based on the coupling effects of fluid–solid–heat under different ocular pressure, four models of rabbit eye were constructed and multi-field coupling vs. fluid–solid interaction was compared in these models. ADINA software was applied to mimic the aqueous humor flow. The contour of temperature demonstrates multiple peaks with larger value near the pupil. The flow pattern is influenced mainly by the variation of ocular pressure. It is necessary to perform multi-field coupling simulation based on dynamic pressure measurement when studying the aqueous humor flow in eyes.

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Numerical simulation of aqueous humor flow to predict the effect of the expanding ring

Advances in Energy Equipment Science and Engineering ◽

10.1201/b19126-430 ◽

2015 ◽

pp. 2231-2236

Author(s):

Y Cong ◽

L Wang ◽

H Yu

Keyword(s):

Numerical Simulation ◽

Aqueous Humor ◽

Aqueous Humor Flow

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Numerical simulation of aqueous humor flow: From healthy to pathologic situations

Applied Mathematics and Computation ◽

10.1016/j.amc.2013.10.070 ◽

2014 ◽

Vol 226 ◽

pp. 777-792 ◽

Cited By ~ 7

Author(s):

J.A. Ferreira ◽

P. de Oliveira ◽

P.M. da Silva ◽

J.N. Murta

Keyword(s):

Numerical Simulation ◽

Aqueous Humor ◽

Aqueous Humor Flow

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Effect of Prostaglandin E2 on aqueous humor flow in the rabbit eye

Graefe s Archive for Clinical and Experimental Ophthalmology ◽

10.1007/bf00407096 ◽

1974 ◽

Vol 190 (3) ◽

pp. 221-227 ◽

Cited By ~ 3

Author(s):

Stephen Tak�ts ◽

Casimir Jobst ◽

Hilda Szilv�ssy

Keyword(s):

Prostaglandin E2 ◽

Aqueous Humor ◽

Rabbit Eye ◽

Aqueous Humor Flow

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Intraocular Pressure and the Mechanisms Involved in Resistance of the Aqueous Humor Flow in the Trabecular Meshwork Outflow Pathways

Progress in Molecular Biology and Translational Science - Molecular Biology of Eye Disease ◽

10.1016/bs.pmbts.2015.06.007 ◽

2015 ◽

pp. 301-314 ◽

Cited By ~ 44

Author(s):

Ernst R. Tamm ◽

Barbara M. Braunger ◽

Rudolf Fuchshofer

Keyword(s):

Intraocular Pressure ◽

Aqueous Humor ◽

Trabecular Meshwork ◽

Aqueous Humor Flow

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Computational Study on the Biomechanics of Pupil Block Phenomenon

BioMed Research International ◽

10.1155/2019/4820167 ◽

2019 ◽

Vol 2019 ◽

pp. 1-10

Author(s):

Wenjia Wang ◽

Hongfang Song ◽

Zhicheng Liu

Keyword(s):

Numerical Simulation ◽

Pupil Diameter ◽

Computational Study ◽

Reference Value ◽

Threshold Value ◽

Practical Method ◽

Angle Closure ◽

Finite Element Models ◽

Aqueous Humor Flow ◽

Primary Angle Closure Glaucoma

Pupil blocking force (PBF) can indicate the potential risk of pupil block (PB), which is considered as a main pathogenic factor of primary angle-closure glaucoma (PACG). However, the effect of PB on the PBF under different pupil diameters and iris-lens channel (ILC) distance was unknown. Besides, a simple and practical method to assess PBF has not been reported yet. In this study, 21 finite element models of eyes with various pupil diameters (2.4 mm–2.6 mm) and ILC (2 μm–20 μm) were constructed and were conducted to simulate aqueous humor flow by fluid-solid coupling numerical simulation. PBF in each model was calculated based on the numerical simulation results and was fitted using response surface methodology. The results demonstrated that ILC distance had a more significant effect than pupil diameter on PBF. With the decrease of ILC distance, the PBF increased exponentially. When the reduced distance was lower than 5 μm, the PBF exploded quickly, resulting in a high risk of iris bomb. The PBF also varied with pupil diameter, especially under the condition of narrow ILC. Both ILC distance and pupil diameter could explain more than 97% variation in PBF, and a second-order empirical model has been developed to be a good predictor of PBF. Based on the linear relationship between anterior chamber deformation and PBF, a threshold value of PBF was given to guide clinical decisions. This study could be used to investigate PACG pathological correlation and its pathogenesis, so as to provide a reference value for clinical diagnosis of PACG.

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