scholarly journals Observation of Effect of Wet Compress of Potato Flake to Treat Preterm Fants with Fat Emulsion Extravasation

2015 ◽  
Vol 05 (03) ◽  
pp. 41-43
Author(s):  
文翰 林
Keyword(s):  
Fat Emulsion ◽  
Potato Flake

scholarly journals Increased myocardial fat supply improves cardiac energetics and function in heart failure

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
W Watson ◽  
P.G Green ◽  
S Neubauer ◽  
O.J Rider
Keyword(s):  
Heart Failure ◽  
Creatine Kinase ◽  
Ejection Fraction ◽  
Funding Source ◽  
Cardiac Energetics ◽  
Fat Emulsion ◽  
Euglycaemic Clamp ◽  
Fat Infusion ◽  
And Function ◽  
Glucose Supply

Abstract Introduction The failing heart is starved of energy, in part accounting for its contractile dysfunction. Reduced uptake of fat and sugar required for energy production has frequently been demonstrated in heart failure, therefore altering metabolism of glucose and/or fat is therefore attractive as a therapy. We hypothesized increasing glucose supply would be beneficial over increasing fat supply so measured ATP usage (via PCr/ATP ratio and flux through creatine kinase) and cardiac function during fat emulsion infusion or euglycaemic hyperinsulinaemic clamp. Methods 11 patients with a diagnosis of heart failure and nonischaemic cardiomyopathy were recruited, mean age 66 (range 49–80), mean BMI 27.7 (range 21.3–37.5), F:M 3:8, 3 diabetic and 8 non-diabetic. On the first visit they had a baseline cardiac magnetic resonance (CMR), collecting cardiac volumes and function, then were randomised to receive either fat infusion or euglycaemic clamp. Following an hour of infusion, CMR was repeated followed by 31P cardiac magnetic resonance spectroscopy, then a dobutamine stress sequence at 65% maximum heart rate. They received the alternate infusion at the next visit. Results Data was normally distributed. Baseline ejection fraction was 37±9%. PCr/ATP ratio was greater with the fat infusion compared to euglycaemic clamp (1.82±0.26 vs 1.68±0.24, p=0.04). Fat emulsion infusion also brought about a greater ejection fraction increase over the baseline, compared to the euglycaemic clamp in which there was little difference (+5.3±5.3% vs −0.6±3.1%, p=0.004). Calculated cardiac work was greater in the fat infusion group than the Insulin/glucose group (682±156 L.mmHg/min vs 581±85 L.mmHg/min, p=0.009). There was no significant difference in creatine kinase first order rate constant (fat infusion 0.2±0.09/s vs euglycaemic clamp 0.16±0.07/s, p=0.32) nor creatine kinase flux (fat infusion 1.85±0.92 μmol/g/s vs euglycaemic clamp 1.46±0.58 μmol/g/s, p=0.22). The increment in cardiac output on stress over baseline was not significantly different between arms (fat infusion +3.39±3.07 L/min vs euglycaemic clamp +3.08±2.57 L/min, p=0.42). The PCr/ATP ratio showed positive correlation with the stress ejection fraction (R2=0.656, p=0.001), but not with resting ejection fraction. Conclusions Increased supply of fat to the myocardium brought about improved contractility and cardiac energetics compared to an increased glucose supply. The increase in PCr/ATP ratio would imply (given ATP concentrations are kept constant in the myocardium) there is a greater availability of phosphocreatine, suggesting increased mitochondrial ATP synthesis. These results were unexpected as it has traditionally been thought that increased glucose metabolism would yield greater cardiac function in the failing heart. These data suggest targeting myocardial fat metabolism may provide novel treatments for cardiac dysfunction. Figure 1 Funding Acknowledgement Type of funding source: Foundation. Main funding source(s): British Heart Foundation

Improvement of graft function and animal survival by fat emulsion in liver transplant rats

2007 ◽  
Vol 54 (1) ◽  
pp. 25-32 ◽  
Author(s):  
Zheng-Wei Ma ◽  
Li-Dong Liu ◽  
Kun Li ◽  
Yu-Jun Zhang ◽  
Jia-Hong Dong
Keyword(s):  
Liver Transplant ◽  
Graft Function ◽  
Fat Emulsion ◽  
Animal Survival

scholarly journals A Modified Fluorescence Polarization Immunoassay Method Incorporating Fat Emulsion(FE-FPIA) to Determine Cyclosporin A Concentrations in Rat Skin.

1999 ◽  
Vol 22 (5) ◽  
pp. 539-542
Author(s):  
Yuji KUROSAKI ◽  
Tomoya ASADA ◽  
Nanae YASUMOTO ◽  
Toshiaki NAKAMURA ◽  
Mikio MASADA ◽  
...  
Keyword(s):  
Cyclosporin A ◽  
Fluorescence Polarization ◽  
Fluorescence Polarization Immunoassay ◽  
Rat Skin ◽  
Fat Emulsion

A Randomized Trial of Micropreemies Receiving Higher Amounts of Intravenous Fat Emulsion During the First Week of Life

2011 ◽  
Vol 4 (1) ◽  
pp. 58-66
Author(s):  
Douglas Drenckpohl ◽  
Matthew Niehaus ◽  
Catherine Schneider ◽  
Connie McConnell ◽  
Huaping Wang ◽  
...  
Keyword(s):  
Randomized Trial ◽  
Fat Emulsion ◽  
Intravenous Fat Emulsion

Metabolic Utilization of Linoleic Acid from Fat Emulsion in Infants during Total Parenteral Nutrition

1988 ◽  
Vol 12 (4) ◽  
pp. 387-391 ◽  
Author(s):  
Jacques Ghisolfi ◽  
Jésus Garcia ◽  
Olga Couvaras ◽  
Jean-Paul Thouvenot ◽  
Jean-Pierre Olives
Keyword(s):  
Linoleic Acid ◽  
Parenteral Nutrition ◽  
Total Parenteral Nutrition ◽  
Fat Emulsion
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