scholarly journals Immunohistochemical Localization of Laminin, Collagen Type IV and Heparan Sulfate Proteoglycan in Human Colorectal Adenocarcinoma: Correlation with Local Invasive Pattern and Lymph Node Metastasis.

1998 ◽  
Vol 31 (1) ◽  
pp. 39-47 ◽  
Author(s):  
Tamotsu Kiyoshima ◽  
Ieyoshi Kobayashi ◽  
Kou Matsuo ◽  
Yukiko Ishibashi ◽  
Akira Miyoshi ◽  
...  
Keyword(s):  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Heparan Sulfate ◽  
Colorectal Adenocarcinoma ◽  
Collagen Type ◽  
Immunohistochemical Localization ◽  
Collagen Type Iv ◽  
Sulfate Proteoglycan ◽  
Node Metastasis ◽  
Type Iv

scholarly journals Mapping of nidogen binding sites for collagen type IV, heparan sulfate proteoglycan, and zinc

1993 ◽  
Vol 268 (15) ◽  
pp. 10881-10887
Author(s):  
D. Reinhardt ◽  
K. Mann ◽  
R. Nischt ◽  
J.W. Fox ◽  
M.L. Chu ◽  
...  
Keyword(s):  
Heparan Sulfate ◽  
Binding Sites ◽  
Collagen Type ◽  
Heparan Sulfate Proteoglycan ◽  
Collagen Type Iv ◽  
Sulfate Proteoglycan ◽  
Type Iv

scholarly journals Colorectal adenocarcinoma with micropapillary pattern and its association with lymph node metastasis

2007 ◽  
Vol 20 (7) ◽  
pp. 729-733 ◽  
Author(s):  
Bisong Haupt ◽  
Jae Y Ro ◽  
Mary R Schwartz ◽  
Steven S Shen
Keyword(s):  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Colorectal Adenocarcinoma ◽  
Node Metastasis ◽  
Micropapillary Pattern

scholarly journals Expression of the Heparan Sulfate Proteoglycan, Perlecan, during Mouse Embryogenesis and Perlecan Chondrogenic Activity In Vitro

1999 ◽  
Vol 145 (5) ◽  
pp. 1103-1115 ◽  
Author(s):  
M.M. French ◽  
S.E. Smith ◽  
K. Akanbi ◽  
T. Sanford ◽  
J. Hecht ◽  
...  
Keyword(s):  
Heparan Sulfate ◽  
Collagen Type ◽  
Heparan Sulfate Proteoglycan ◽  
Surrounding Tissue ◽  
Collagen Type Iv ◽  
Type Ii ◽  
Sulfate Proteoglycan ◽  
Collagen Type Ii ◽  
Murine Embryonic Fibroblast

Expression of the basement membrane heparan sulfate proteoglycan (HSPG), perlecan (Pln), mRNA, and protein has been examined during murine development. Both Pln mRNA and protein are highly expressed in cartilaginous regions of developing mouse embryos, but not in areas of membranous bone formation. Initially detected at low levels in precartilaginous areas of d 12.5 embryos, Pln protein accumulates in these regions through d 15.5 at which time high levels are detected in the cartilage primordia. Laminin and collagen type IV, other basal lamina proteins commonly found colocalized with Pln, are absent from the cartilage primordia. Accumulation of Pln mRNA, detected by in situ hybridization, was increased in d 14.5 embryos. Cartilage primordia expression decreased to levels similar to that of the surrounding tissue at d 15.5. Pln accumulation in developing cartilage is preceded by that of collagen type II. To gain insight into Pln function in chondrogenesis, an assay was developed to assess the potential inductive activity of Pln using multipotential 10T1/2 murine embryonic fibroblast cells. Culture on Pln, but not on a variety of other matrices, stimulated extensive formation of dense nodules reminiscent of embryonic cartilaginous condensations. These nodules stained intensely with Alcian blue and collagen type II antibodies. mRNA encoding chondrocyte markers including collagen type II, aggrecan, and Pln was elevated in 10T1/2 cells cultured on Pln. Human chondrocytes that otherwise rapidly dedifferentiate during in vitro culture also formed nodules and expressed high levels of chondrocytic marker proteins when cultured on Pln. Collectively, these studies demonstrate that Pln is not only a marker of chondrogenesis, but also strongly potentiates chondrogenic differentiation in vitro.

scholarly journals Predictive factors of lymph node metastasis in patients with non-metastatic colorectal adenocarcinoma

2016 ◽  
Vol 27 ◽  
pp. vi177
Author(s):  
E. Karcı ◽  
E.B. Köksoy ◽  
A. Alkan ◽  
İ Dede ◽  
G. Tuncay ◽  
...  
Keyword(s):  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Predictive Factors ◽  
Colorectal Adenocarcinoma ◽  
Node Metastasis

scholarly journals Factors Associated with Lymphovascular Invasion in Colorectal Adenocarcinoma at Dr. Cipto Mangunkusumo General Hospital, Jakarta: A Preliminary Report

2020 ◽  
Vol 3 (1) ◽  
Keyword(s):  
Lymph Node ◽  
Lymph Node Metastasis ◽  
General Hospital ◽  
Preliminary Report ◽  
Lymphovascular Invasion ◽  
Colorectal Adenocarcinoma ◽  
P Value ◽  
Cross Sectional ◽  
Factors Associated ◽  
Node Metastasis

Background: Lymph node metastasis is a prognostic factor in colorectal adenocarcinoma. Besides, lymphovascular invasion is one of the factors to indicate the lymph node metastasis. This study aimed to investigate factors associated with lymphovascular invasion in our hospital. Methods: This preliminary report was a cross−sectional study of patients with colorectal adenocarcinoma in Cipto Manungkusumo General Hospital, Jakarta, Indonesia between 2012 and 2016. Our focus of interest was the association between lymphovascular invasion and variables of patient’s characteristics, including age, gender, location of the tumor, tumor differentiation, pathological stage of tumor infiltration, and lymph node metastasis. Results: We found 70% of the 68 subjects had lymphovascular invasions. Among all the variables analyzed for association with lymphovascular invasion, there is no factor with significant association. However, lymph node metastasis was found to have significant association with lymphovascular invasion (odd ratio [OR] = 6.69, 95% confidence interval [CI] = 2.09–21.38, p−value =0.001). Conclusion: Although lymphovascular invasion was significantly associated with lymph node metastasis in colorectal adenocarcinoma, there is no factor significantly associated with lymphovascular invasion in this study.

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