scholarly journals Colorectal adenocarcinoma with micropapillary pattern and its association with lymph node metastasis

2007 ◽  
Vol 20 (7) ◽  
pp. 729-733 ◽  
Author(s):  
Bisong Haupt ◽  
Jae Y Ro ◽  
Mary R Schwartz ◽  
Steven S Shen
2016 ◽  
Vol 27 ◽  
pp. vi177
Author(s):  
E. Karcı ◽  
E.B. Köksoy ◽  
A. Alkan ◽  
İ Dede ◽  
G. Tuncay ◽  
...  

2020 ◽  
Vol 3 (1) ◽  

Background: Lymph node metastasis is a prognostic factor in colorectal adenocarcinoma. Besides, lymphovascular invasion is one of the factors to indicate the lymph node metastasis. This study aimed to investigate factors associated with lymphovascular invasion in our hospital. Methods: This preliminary report was a cross−sectional study of patients with colorectal adenocarcinoma in Cipto Manungkusumo General Hospital, Jakarta, Indonesia between 2012 and 2016. Our focus of interest was the association between lymphovascular invasion and variables of patient’s characteristics, including age, gender, location of the tumor, tumor differentiation, pathological stage of tumor infiltration, and lymph node metastasis. Results: We found 70% of the 68 subjects had lymphovascular invasions. Among all the variables analyzed for association with lymphovascular invasion, there is no factor with significant association. However, lymph node metastasis was found to have significant association with lymphovascular invasion (odd ratio [OR] = 6.69, 95% confidence interval [CI] = 2.09–21.38, p−value =0.001). Conclusion: Although lymphovascular invasion was significantly associated with lymph node metastasis in colorectal adenocarcinoma, there is no factor significantly associated with lymphovascular invasion in this study.


2011 ◽  
Vol 59 (6) ◽  
pp. 1081-1089 ◽  
Author(s):  
Tetsuo Ushiku ◽  
Keisuke Matsusaka ◽  
Yoshiaki Iwasaki ◽  
Yoko Tateishi ◽  
Nobuaki Funata ◽  
...  

2016 ◽  
Vol 39 (1) ◽  
pp. 1-8
Author(s):  
Isidro Machado ◽  
Miriam Valera-Alberni ◽  
Fernando Martínez de Juan ◽  
José A. López-Guerrero ◽  
Alfonso García Fadrique ◽  
...  

2009 ◽  
Vol 16 (6) ◽  
pp. 1711-1719 ◽  
Author(s):  
Ray-Hwang Yuan ◽  
Chi-Chao Wang ◽  
Chia-Cheng Chou ◽  
King-Jen Chang ◽  
Po-Huang Lee ◽  
...  

2018 ◽  
Vol 54 (1) ◽  
pp. 1
Author(s):  
Ladyna Rumapar ◽  
Sjahjenny Mustokoweni ◽  
Alphania Rahniayu

Colorectal carcinoma has high morbidity and mortality rate worldwide, in which over 90% are adenocarcinoma. Colorectal carcinoma is one of the most cancer that metastasize to the lymph node. Angiogenesis have an important role in tumor growth and metastasis. Hypoxia is the trigger factor for angiogenesis. Hypoxia induced factor-1 (HIF-1) is one critical protein directly reacting to hypoxia. HIF-1alpha, a HIF-1 subunit, is an important regulator of angiogenesis. This study analyzed HIF-1a expression in colorectal adenocarcinoma with and without regional lymph node metastasis. This study was to prove that HIF-1a has a role in regional lymph node metastasis in colorectal adenocarcinoma. An analytical observational study was conducted on thirty formalin fixed paraffin-embedded colorectal adenocarcinoma tissues from Anatomic Pathology Laboratory of Dr. Soetomo Hospital. Detection of HIF-1alpha expressions were performed with immunohistochemistry method, using HIF-1alpha antibody. It were statistically analyzed using Mann-Whitney and Kruskal- Wallis methods. There were no significant differences in the expression of HIF-1alpha in colorectal adenocarcinoma with or without lymph node (LN) metastasis (p>0.05). As a conclusion, this study showed that HIF-1alpha has no role in LN metastasis in colorectal adenocarcinoma.


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