scholarly journals Regeneration of Parietal Cells at the Healing Process of Acetic Acid-induced Gastric Ulcers in Rats. Evaluation of the Quality of Ulcer Healing by the Administration of Various Agents.

1995 ◽  
Vol 28 (1) ◽  
pp. 73-76
Author(s):  
Katsuya Nakano ◽  
Hideyuki Konishi ◽  
Masao Noda ◽  
Hitomi Sato ◽  
Tadashi Kodama ◽  
...  
Keyword(s):  
Acetic Acid ◽  
Ulcer Healing ◽  
Healing Process ◽  
Parietal Cells ◽  
Gastric Ulcers ◽  
Quality Of Ulcer Healing

Quality of ulcer healing influences the relapse of gastric ulcers in humans

1997 ◽  
Vol 12 (2) ◽  
pp. 109-114 ◽  
Author(s):  
HIROKO NEBIKI ◽  
TETSUO ARAKAWA ◽  
KAZUHIDE HIGUCHI ◽  
KENZO KOBAYASHI
Keyword(s):  
Ulcer Healing ◽  
Gastric Ulcers ◽  
Quality Of Ulcer Healing

Quality of ulcer healing—A new concept to rank healed peptic ulcers

1993 ◽  
Vol 28 (S5) ◽  
pp. 158-162 ◽  
Author(s):  
Tetsuo Arakawa ◽  
Kenzo Kobayashi
Keyword(s):  
Ulcer Healing ◽  
Peptic Ulcers ◽  
Quality Of Ulcer Healing

Effect of eradication of Helicobacter pylori on quality of ulcer healing evaluated endoscopically and histologically

1995 ◽  
Vol 41 (4) ◽  
pp. 365
Author(s):  
K. Higuchi ◽  
T. Uchida ◽  
H. Nebiki ◽  
H. Itoh ◽  
T. Fukuda ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Ulcer Healing ◽  
Quality Of Ulcer Healing

Bacteria rapidly colonize and modulate healing of gastric ulcers in rats

1998 ◽  
Vol 275 (3) ◽  
pp. G425-G432 ◽  
Author(s):  
Susan N. Elliott ◽  
André Buret ◽  
Webb McKnight ◽  
Mark J. S. Miller ◽  
John L. Wallace
Keyword(s):  
Ulcer Healing ◽  
Bacterial Colonization ◽  
Healing Process ◽  
Gastric Ulcers ◽  
Gram Negative Bacteria ◽  
Antibiotic Resistant ◽  
Gram Negative ◽  
E Coli ◽  
Beneficial Effects ◽  
The Relationship

The stomach is generally regarded as an environment that is not conducive to bacterial colonization. In this study, we examined the possibility that this changes significantly when an ulcer has formed and that colonization of ulcers interferes with the normal healing process. Gastric ulcers were induced by serosal application of acetic acid. The relationship between ulcer healing and bacterial colonization was examined. The effects of antibiotics, induction of Lactobacilluscolonization, and selective colonization with an antibiotic resistant strain of Escherichia coli on ulcer healing were examined. Within 6–12 h of their induction, gastric ulcers were colonized by a variety of bacteria, with gram-negative bacteria predominating. Suppression of colonization with antibiotics resulted in marked acceleration of healing. Induction of Lactobacillus colonization also accelerated ulcer healing. The beneficial effects of antibiotics were reversed through selective colonization with antibiotic-resistant E. coli. Bacterial colonization occurred irrespective of the method used to induce the ulcer. This study demonstrates that colonization of gastric ulcers in rats occurs rapidly and significantly impairs ulcer healing. This effect appeared to be primarily attributable to gram-negative bacteria.

scholarly journals Immunohistochemical Studies of Age-Related Changes in Cell Proliferation and Angiogenesis during the Healing of Acetic Acid-Induced Gastric Ulcers in Rats

2020 ◽  
Vol 2020 ◽  
pp. 1-10
Author(s):  
A. Folorunsho Ajayi ◽  
S. Babafemi Olaleye
Keyword(s):  
Cell Proliferation ◽  
Acetic Acid ◽  
Gastric Ulcer ◽  
Factor Viii ◽  
Ulcer Healing ◽  
Gastric Ulcers ◽  
Gastric Injury ◽  
Tissue Samples ◽  
Age Related ◽  
Male Wistar Rats

Cell proliferation and angiogenesis are of utmost importance for healing to take place. The KI67 and EGFR proteins are markers of cell proliferation, while CD31 and factor VIII are markers of angiogenesis. To elucidate the mechanism responsible for delayed healing of the gastric injury in old age, we analyzed the expression of these markers in rats of different months during the healing of an acetic acid-induced gastric ulcer. Male Wistar rats (aged 3, 6, 12, and 18 months) divided into four groups, according to their ages, formed the experimental animals. Stomach tissue samples were collected on days 3, 7, 14, and 21 after induction for assessment of ulcer healing. The area of gastric mucosa healed was inversely proportional to age. The expression of markers of proliferation (KI67 and EGFR) and angiogenesis (factor VIII and CD31) decreased significantly (p<0.05) in older rats when compared with younger ones (3 months > six months > 12 months > 18 months) on days 7, 14, and 21 after induction of gastric ulcer. This study revealed that the slower gastric ulcer healing rate in older rats might be due to reduced epithelial cell proliferation and angiogenic activities.

scholarly journals Role of microsomal prostaglandin E synthase-1 in the facilitation of angiogenesis and the healing of gastric ulcers

2010 ◽  
Vol 299 (5) ◽  
pp. G1139-G1146 ◽  
Author(s):  
Takako Ae ◽  
Takashi Ohno ◽  
Youichiro Hattori ◽  
Tatsunori Suzuki ◽  
Kanako Hosono ◽  
...  
Keyword(s):  
Acetic Acid ◽  
Growth Factor ◽  
Ulcer Healing ◽  
Transforming Growth Factor ◽  
Tissue Growth ◽  
Gastric Ulcers ◽  
Prostaglandin E ◽  
Mrna Levels ◽  
Healing Processes

The importance of prostaglandin E2 in various pathophysiological events emphasizes the necessity of understanding the role of PGE synthases (PGESs) in vivo. However, there has been no report on the functional relevance of microsomal PGES-1 (mPGES-1) to the physiological healing processes of gastric ulcers, or to angiogenesis, which is indispensable to the healing processes. In this report, we tested whether mPGES-1 plays a role in the healing of gastric ulcers and in the enhancement of angiogenesis using mPGES-1 knockout mice (mPGES-1 KO mice) and their wild-type (WT) counterparts. Gastric ulcers were induced by the serosal application of 100% acetic acid, and the areas of the ulcers were measured thereafter. mPGES-1 together with cyclooxygenase-2 were induced in the granulation tissues compared with normal stomach tissues. The healing of acetic acid-induced ulcers was significantly delayed in mPGES-1 KO mice compared with WT. This was accompanied with reduced angiogenesis in ulcer granulation tissues, as estimated by CD31 mRNA levels determined by real-time PCR and the microvessel density in granulation tissues. The mRNA levels of proangiogenic growth factors, such as transforming growth factor-β, basic fibroblast growth factor, and connective tissue growth factor in ulcer granulation tissues determined were reduced in mPGES-1 KO mice compared with WT. The present results suggest that mPGES-1 enhances the ulcer-healing processes and the angiogenesis indispensable to ulcer healing, and that a selective mPGES-1 inhibitor should be used with care in patients with gastric ulcers.

scholarly journals Gastroprotective Mechanism and Ulcer Resolution Effect of Cyrtocarpa procera Methanolic Extract on Ethanol-Induced Gastric Injury

2018 ◽  
Vol 2018 ◽  
pp. 1-12 ◽  
Author(s):  
Wendy Itzel Escobedo-Hinojosa ◽  
Erika Gomez-Chang ◽  
Karina García-Martínez ◽  
Raquel Guerrero Alquicira ◽  
Alexandre Cardoso-Taketa ◽  
...  
Keyword(s):  
Methanolic Extract ◽  
Clinical Symptoms ◽  
Gastric Ulcers ◽  
Gastric Injury ◽  
Inflammatory Infiltration ◽  
Area Reduction ◽  
Quality Of Ulcer Healing ◽  
Gastric Mucosal Erosions ◽  
Ulcer Treatment

Gastric ulcers are a worldwide health problem and their poor healing is one of the most important causes for their recurrence. We have previously reported the remarkable gastroprotective and anti-Helicobacter pylori activities of the methanolic extract (CpMet) of Cyrtocarpa procera bark. This work investigates, in a murine model, the CpMet gastroprotective mechanism and establishes its preclinical efficacy in the resolution of ethanol-induced gastric ulcers. The results showed that the gastroprotective activity of CpMet is mainly associated with endogenous NO and prostaglandins, followed by sulfhydryl groups and KATP channels. Furthermore, CpMet (300 mg/kg, twice a day) orally administered during 20 consecutive days promoted an ulcer area reduction of 62.65% at the 20th day of the treatment. The effect was confirmed macroscopically by the alleviation of gastric mucosal erosions and microscopically by an increase in mucin content and a reduction in the inflammatory infiltration at the site of the ulcer. No clinical symptoms or signs of toxicity were observed in the treated animals. The results indicate the safety and efficacy of CpMet in promoting high quality of ulcer healing by different mechanisms, but mostly through cytoprotective and anti-inflammatory effects, making it a promising phytodrug for ulcer treatment.

Endosonographic Evaluation of the Quality of Ulcer Healing Induced by Proton Pump Inhibitors

1995 ◽  
Vol 20 ◽  
pp. S40-S43 ◽  
Author(s):  
Yoshihisa Tsukamoto ◽  
Hidemi Goto ◽  
Satoshi Hase ◽  
Yasumasa Niwa ◽  
Tomiyasu Arisawa ◽  
...  
Keyword(s):  
Proton Pump Inhibitors ◽  
Proton Pump ◽  
Ulcer Healing ◽  
Quality Of Ulcer Healing
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