scholarly journals Biochemical and immunohistochemical studies of glutathione peroxidase in the rat adrenal cortex.

1981 ◽  
Vol 14 (6) ◽  
pp. 571-580 ◽  
Author(s):  
MASANORI MURAKOSHI ◽  
R. YOSHIYUKI OSAMURA ◽  
SHINICHI YOSHIMURA ◽  
SHINICHI IZUMI ◽  
NORIYUKI KOMATSU ◽  
...  
Keyword(s):  
Glutathione Peroxidase ◽  
Adrenal Cortex ◽  
Immunohistochemical Studies

Ultrastructural and immunohistochemical studies on the zona-reticularis cells of the adrenal cortex of normal and 3-methylcholanthrene-treated mice

1985 ◽  
Vol 83 (3-4) ◽  
pp. 207-211
Author(s):  
M. Usa ◽  
K. Ishimura ◽  
H. Fujita ◽  
S. Sugano ◽  
M. Okamoto ◽  
...  
Keyword(s):  
Adrenal Cortex ◽  
Zona Reticularis ◽  
Immunohistochemical Studies

Leptin receptors in the adrenal medulla of the rat

1997 ◽  
Vol 273 (2) ◽  
pp. E448-E452 ◽  
Author(s):  
G. Y. Cao ◽  
R. V. Considine ◽  
R. B. Lynn
Keyword(s):  
Adrenal Cortex ◽  
Adrenal Medulla ◽  
Leptin Receptor ◽  
Specific Binding ◽  
Protein Product ◽  
Leptin Receptors ◽  
Receptor Mrna ◽  
Site Of Action ◽  
Polymerase Chain ◽  
Immunohistochemical Studies

Leptin is the protein product of the recently cloned obesity gene. Leptin receptor mRNA is found in a number of central and peripheral locations. The hypothalamus is a presumed site of action. However, little is known about the specific locations of the receptor in peripheral organs. Epinephrine has potent anorectic effects and can cause weight loss by a variety of mechanisms. Excretion of epinephrine is reduced in the ob/ob mouse, which lacks leptin, suggesting an effect by leptin on the adrenal medulla. In the current study, the presence of the leptin receptor was identified on epinephrine-secreting cells in the adrenal medulla. Immunohistochemical studies found dense leptin receptor-like immunoreactivity in the adrenal medulla with no labeling in the adrenal cortex. Double immunofluorescent labeling confirmed that the leptin receptor was present on cells that were phenylethanolamine N-methyltransferase-like immunoreactive and therefore were epinephrine-secreting cells. Leptin receptor mRNA in the adrenal medulla was detected by reverse transcriptase-polymerase chain reaction, with the majority of the mRNA coding for the short isoform (Ob-Ra) of the receptor. Finally, autoradiography was performed using 125I-labeled leptin; specific binding was found in the adrenal medulla, with no specific binding in the adrenal cortex. These results suggest that leptin may have a direct effect on epinephrine-secreting cells in the adrenal medulla. Epinephrine may play a role in mediating the effects of leptin to reduce body weight.

Developmental changes in steroidogenic enzymes in human postnatal adrenal cortex: immunohistochemical studies

2000 ◽  
Vol 53 (6) ◽  
pp. 739-747 ◽  
Author(s):  
Takashi Suzuki ◽  
Hironobu Sasano ◽  
Junji Takeyama ◽  
Chika Kaneko ◽  
William A. Freije ◽  
...  
Keyword(s):  
Adrenal Cortex ◽  
Developmental Changes ◽  
Steroidogenic Enzymes ◽  
Immunohistochemical Studies

Ultrastructural Cytopiasmic Changes of Adrenal Cortex During Pregnancy

1969 ◽  
Vol 27 ◽  
pp. 298-299
Author(s):  
T. M. Murad ◽  
Karen Israel ◽  
Jack C. Geer
Keyword(s):  
Adrenal Gland ◽  
Steroid Hormones ◽  
Adrenal Cortex ◽  
Lipid Droplets ◽  
Plasma Cholesterol ◽  
Adrenal Steroids ◽  
Dynamic Changes ◽  
Cortical Cells ◽  
Acetyl Coenzyme A ◽  
Adrenal Cortical Cells

Adrenal steroids are normally synthesized from acetyl coenzyme A via cholesterol. Cholesterol is also shown to enter the adrenal gland and to be localized in the lipid droplets of the adrenal cortical cells. Both pregnenolone and progesterone act as intermediates in the conversion of cholesterol into steroid hormones. During pregnancy an increased level of plasma cholesterol is known to be associated with an increase of the adrenal corticoid and progesterone. The present study is designed to demonstrate whether the adrenal cortical cells show any dynamic changes during pregnancy.

Adrenocortical Ultrastructure in Ectopic Acth Syndrome

1976 ◽  
Vol 34 ◽  
pp. 238-239
Author(s):  
K. Kovacs ◽  
E. Horvath ◽  
W. Singer
Keyword(s):  
Adrenal Cortex ◽  
Zona Glomerulosa ◽  
Ectopic Acth Syndrome ◽  
Pituitary Neoplasms ◽  
Electron Microscopic ◽  
Adrenocortical Cells ◽  
Cell Hyperplasia ◽  
Ectopic Acth ◽  
Ectopic Acth Production ◽  
Microscopic Findings

Secretion of ACTH by non-pituitary neoplasms is recognized with increasing frequency. While the clinical and biochemical changes associated with ectopic ACTH production have been extensively studied recently, relatively little attention was focused on the morphology of the adrenal cortex and, to our knowledge, the fine structure of the adrenocortical cells in cases of ectopic ACTH syndrome has not been described so far. We report here the electron microscopic findings in the adrenal cortex of a 50-year-old man with a pancreatic apudoma. The patient showed the characteristic clinical and biochemical features of ectopic ACTH syndrome and because of extensive hypercorticism, underwent bilateral adrenalectomy.By light microscopy, the adrenal cortices showed extensive compact cell hyperplasia and lipid depletion. The zona glomerulosa was present in small foci and, except for a few places, fasciculata cells were noted under the fibrous capsule.

Immunohistochemical studies on 3β-hydroxysteroid dehydrogenase in the adult human adrenal

1998 ◽  
Vol 5 (1) ◽  
pp. 94A-94A
Author(s):  
R MIXON ◽  
R BRISSIE ◽  
W GRIZZLE ◽  
J THOMAS ◽  
O FAYEPELERSEN ◽  
...  
Keyword(s):  
Hydroxysteroid Dehydrogenase ◽  
Adult Human ◽  
Immunohistochemical Studies
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