scholarly journals Successful implantation of a decellularized equine pericardial patch into the systemic circulation

2014 ◽  
Vol 20 ◽  
pp. 1-8 ◽  
Author(s):  
Pascal Maria Dohmen ◽  
Francisco da Costa ◽  
Sergio Vega Lopes ◽  
Ricardo Vilani ◽  
Oliver Bloch ◽  
...  
Keyword(s):  
Systemic Circulation ◽  
Pericardial Patch ◽  
Equine Pericardial Patch

Repair of gastric defects with an equine pericardial patch

Surgery Today ◽  
2014 ◽  
Vol 45 (1) ◽  
pp. 83-90
Author(s):  
Kostantinos Spiliopoulos ◽  
Charalampos Markakis ◽  
Periklis Tomos ◽  
Hariklia Gakiopoulou ◽  
Ioannis Nikolopoulos ◽  
...  
Keyword(s):  
Pericardial Patch ◽  
Equine Pericardial Patch

scholarly journals Η χρήση μεβράνης κολλαγόνου ίππειου περικάρδιου για την αποκατάσταση ελλειμάτων στομάχου

2015 ◽  
Author(s):  
Κωνσταντίνος Σπηλιόπουλος
Keyword(s):  
Operative Procedure ◽  
Anterior Wall ◽  
Bursting Pressure ◽  
Pericardial Patch ◽  
Time Intervals ◽  
Equine Pericardial Patch ◽  
Upper Gastrointestinal ◽  
New Zealand Rabbits ◽  
Muscular Regeneration ◽  
Observation Period

Objective The objective of this study was to test the efficacy of an equine pericardial patch forthe repair of full-thickness defects of the stomach wall.Materials and methods Circular defects of 1.5 cm diameter, on the anterior wall of thestomach of 12 female New Zealand rabbits, were repaired by an equine pericardial patch.After euthanasia at six different time intervals (3 days- 8 weeks) macroscopic evaluation of theabdominal cavity (including adhesion scoring), mechanical testing and histologicalexamination of the stomach were performed.Results All animals survived the operative procedure and had a normal post-operative course,without complications, until euthanasia. None of the patches failed and the abdomen remainedgrossly intact in all cases. Adhesions were observed in all animals and were quite significant in3/12 animals. Bursting pressure testing indicated that the repair was durable and that adequatestrength to prevent local failure was achieved by the second week. Histological examinationshowed gradual narrowing of the perforation site by mucosal and limited muscular regeneration. By the end of the observation period, a well-organized, vascularized, andstructured fibrotic layer had formed on the outside of the patch, which was undergoing slowdegradation.Conclusions The equine pericardial patch was successfully used to repair a gastric defect inour experimental model and it seems that it could have potential as a material suitable forfurther research, concerning repair of upper gastrointestinal defects.

Combined hepatic resection with the inferior vena cava and diaphragm and reconstruction using an equine pericardial patch: Report of a case

Surgery Today ◽  
2011 ◽  
Vol 41 (12) ◽  
pp. 1670-1673 ◽  
Author(s):  
Koji Asai ◽  
Manabu Watanabe ◽  
Hiroshi Matsukiyo ◽  
Akihiro Osawa ◽  
Tomoaki Saito ◽  
...  
Keyword(s):  
Inferior Vena Cava ◽  
Hepatic Resection ◽  
Inferior Vena ◽  
Vena Cava ◽  
Pericardial Patch ◽  
Equine Pericardial Patch

Gut microbiome a promising target for management of respiratory diseases

2020 ◽  
Vol 477 (14) ◽  
pp. 2679-2696
Author(s):  
Riddhi Trivedi ◽  
Kalyani Barve
Keyword(s):  
Respiratory Diseases ◽  
New Technology ◽  
Bacterial Flora ◽  
Systemic Circulation ◽  
The Body ◽  
Lung Pathology ◽  
Promising Target ◽  
Current Therapies ◽  
Intestinal Microbial Flora ◽  
On Chip

The intestinal microbial flora has risen to be one of the important etiological factors in the development of diseases like colorectal cancer, obesity, diabetes, inflammatory bowel disease, anxiety and Parkinson's. The emergence of the association between bacterial flora and lungs led to the discovery of the gut–lung axis. Dysbiosis of several species of colonic bacteria such as Firmicutes and Bacteroidetes and transfer of these bacteria from gut to lungs via lymphatic and systemic circulation are associated with several respiratory diseases such as lung cancer, asthma, tuberculosis, cystic fibrosis, etc. Current therapies for dysbiosis include use of probiotics, prebiotics and synbiotics to restore the balance between various species of beneficial bacteria. Various approaches like nanotechnology and microencapsulation have been explored to increase the permeability and viability of probiotics in the body. The need of the day is comprehensive study of mechanisms behind dysbiosis, translocation of microbiota from gut to lung through various channels and new technology for evaluating treatment to correct this dysbiosis which in turn can be used to manage various respiratory diseases. Microfluidics and organ on chip model are emerging technologies that can satisfy these needs. This review gives an overview of colonic commensals in lung pathology and novel systems that help in alleviating symptoms of lung diseases. We have also hypothesized new models to help in understanding bacterial pathways involved in the gut–lung axis as well as act as a futuristic approach in finding treatment of respiratory diseases caused by dysbiosis.

Vascular adaptations to hypoxia: molecular and cellular mechanisms regulating vascular tone

2007 ◽  
Vol 43 ◽  
pp. 105-120 ◽  
Author(s):  
Michael L. Paffett ◽  
Benjimen R. Walker
Keyword(s):  
Vascular Tone ◽  
Cellular Proliferation ◽  
Hypoxic Pulmonary Vasoconstriction ◽  
Hypoxia Inducible Factor ◽  
Systemic Circulation ◽  
Cellular Mechanisms ◽  
Hypoxia Inducible Factor 1 ◽  
Pulmonary Vasoconstriction ◽  
Adaptive Mechanisms ◽  
Adaptive Processes

Several molecular and cellular adaptive mechanisms to hypoxia exist within the vasculature. Many of these processes involve oxygen sensing which is transduced into mediators of vasoconstriction in the pulmonary circulation and vasodilation in the systemic circulation. A variety of oxygen-responsive pathways, such as HIF (hypoxia-inducible factor)-1 and HOs (haem oxygenases), contribute to the overall adaptive process during hypoxia and are currently an area of intense research. Generation of ROS (reactive oxygen species) may also differentially regulate vascular tone in these circulations. Potential candidates underlying the divergent responses between the systemic and pulmonary circulations may include Nox (NADPH oxidase)-derived ROS and mitochondrial-derived ROS. In addition to alterations in ROS production governing vascular tone in the hypoxic setting, other vascular adaptations are likely to be involved. HPV (hypoxic pulmonary vasoconstriction) and CH (chronic hypoxia)-induced alterations in cellular proliferation, ionic conductances and changes in the contractile apparatus sensitivity to calcium, all occur as adaptive processes within the vasculature.

Iron and Malaria: Absorption, Efficacy and Safety

2010 ◽  
Vol 80 (45) ◽  
pp. 279-292 ◽  
Author(s):  
Richard Hurrell
Keyword(s):  
Pathogenic Bacteria ◽  
Intestinal Barrier ◽  
Systemic Circulation ◽  
Malarial Parasite ◽  
Asymptomatic Malaria ◽  
Iron Supplements ◽  
Fortified Food ◽  
Care Giving ◽  
Single Meal ◽  
Women And Children

Febrile malaria and asymptomatic malaria parasitemia substantially decrease iron absorption in single-meal, stable isotope studies in women and children, but to date there is no evidence of decreased efficacy of iron-fortified foods in malaria-endemic regions. Without inadequate malarial surveillance or health care, giving iron supplements to children in areas of high transmission could increase morbidity and mortality. The most likely explanation is the appearance of non-transferrin-bound iron (NTBI) in the plasma. NTBI forms when the rate of iron influx into the plasma exceeds the rate of iron binding to transferrin. Two studies in women have reported substantially increased NTBI with the ingestion of iron supplements. Our studies confirm this, but found no significant increase in NTBI on consumption of iron-fortified food. It seems likely that the malarial parasite in hepatocytes can utilize NTBI, but it cannot do so in infected erythrocytes. NTBI however may increase the sequestration of parasite-infected erythrocytes in capillaries. Bacteremia is common in children with severe malaria and sequestration in villi capillaries could lead to a breaching of the intestinal barrier, allowing the passage of pathogenic bacteria into the systemic circulation. This is especially important as frequent high iron doses increase the number of pathogens in the intestine at the expense of the barrier bacteria.

Ex vivo expansion of autologous pericardial patch structures

2008 ◽  
Vol 56 (S 1) ◽  
Author(s):  
P Veggian ◽  
TC Flanagan ◽  
B Hesse ◽  
J Sachweh ◽  
S Koch ◽  
...  
Keyword(s):  
Ex Vivo ◽  
Ex Vivo Expansion ◽  
Pericardial Patch ◽  
Autologous Pericardial Patch
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