scholarly journals Efficacy, Drug Sensitivity, and Safety of a Chronic Ocular Hypertension Rat Model Established Using a Single Intracameral Injection of Hydrogel into the Anterior Chamber

2020 ◽  
Vol 26 ◽  
Author(s):  
Huan Yu ◽  
Huimin Zhong ◽  
Junjue Chen ◽  
Jun Sun ◽  
Ping Huang ◽  
...  
Keyword(s):  
Anterior Chamber ◽  
Ocular Hypertension ◽  
Rat Model ◽  
Drug Sensitivity ◽  
Intracameral Injection

scholarly journals Hypotensive Effect of Nanomicellar Formulation of Melatonin and Agomelatine in a Rat Model: Significance for Glaucoma Therapy

Diagnostics ◽  
2020 ◽  
Vol 10 (3) ◽  
pp. 138 ◽  
Author(s):  
Massimo Dal Monte ◽  
Maurizio Cammalleri ◽  
Salvatore Pezzino ◽  
Roberta Corsaro ◽  
Nicola Pescosolido ◽  
...  
Keyword(s):  
Intraocular Pressure ◽  
Anterior Chamber ◽  
Ocular Hypertension ◽  
Lipoic Acid ◽  
Rat Model ◽  
Hypotensive Effect ◽  
Glaucoma Therapy ◽  
Lowering Effect

Background: Melatoninergic agents are known to reduce intraocular pressure (IOP). The present study was performed to evaluate the effect of nanomicellar formulations of melatoninergic agents on IOP in the rat. Methods: Tonometry was used to measure IOP in eyes instilled with melatonin or agomelatine. Ocular hypertension was induced by the injection of methylcellulose in the anterior chamber. Results: Melatonin formulated in nanomicelles had a longer lasting hypotonizing effect on IOP with respect to melatonin in saline. Nanomicellar formulations of melatonin and agomelatine, either alone or in combination, had lowering effects that did not depend on their concentration or their combination, which, however, resulted in an increased duration of the hypotonizing effect. The duration of the lowering effect was further increased by the addition of lipoic acid. Conclusions: We demonstrated the effective hypotonizing activity of melatonin and agomelatine in combination with lipoic acid. Although results in animals cannot be directly translated to humans, the possibility of developing novel therapeutical approaches for patients suffering from hypertensive glaucoma should be considered.

scholarly journals Platelet-Derived Growth Factor Preserves Retinal Synapses in a Rat Model of Ocular Hypertension

2016 ◽  
Vol 57 (3) ◽  
pp. 842 ◽  
Author(s):  
Rachel S. Chong ◽  
Andrew Osborne ◽  
Raquel Conceição ◽  
Keith R. Martin
Keyword(s):  
Growth Factor ◽  
Ocular Hypertension ◽  
Rat Model ◽  
Platelet Derived Growth Factor

scholarly journals Pars Plana Vitrectomy and the Risk of Ocular Hypertension and Glaucoma: Where Are We?

2020 ◽  
Vol 9 (12) ◽  
pp. 3994
Author(s):  
Tommaso Rossi ◽  
Guido Ripandelli
Keyword(s):  
Anterior Chamber ◽  
Ocular Hypertension ◽  
Oxygen Tension ◽  
Pars Plana Vitrectomy ◽  
Open Angle Glaucoma ◽  
Crystalline Lens ◽  
Cataract Extraction ◽  
Oxygen Scavenger ◽  
Clinical Series ◽  
Pars Plana

Purpose is to review the pathogenic mechanism for ocular hypertension and glaucoma development after pars plana vitrectomy. Both acute and chronic causes are considered, and special attention is paid to the theories and clinical evidence on the risk of developing Open Angle Glaucoma (OAG) after Pars Plana Vitrectomy (PPV). Most existing scientific literature on the issue agree on the role of ascorbate as an oxygen scavenger within the vitreous chamber. Oxygen tension in the vitreous and anterior chamber is maximum inn proximity of the retinal surface and endothelium, respectively and steeply decreases toward the lens, on both sides, and trabecular meshwork. Vitreous removal and, to a lesser extent, liquefaction, greatly reduces oxygen tension gradient in vitreous chamber while cataract extraction has similar effects on anterior chamber oxygen gradients. Oxygen derivatives originated from the cornea and retina are actively reduced by the vitreous gel and/or the crystalline lens. Vitreous removal and cataract extraction reduce drastically this function. Most reported clinical series confirm this hypothesis although protocol difference and follow-up length greatly impact the reliability of results.

scholarly journals Neuroprotective Effects of Transcription Factor Brn3b in an Ocular Hypertension Rat Model of Glaucoma

2015 ◽  
Vol 56 (2) ◽  
pp. 893-907 ◽  
Author(s):  
D. L. Stankowska ◽  
A. Z. Minton ◽  
M. A. Rutledge ◽  
B. H. Mueller ◽  
N. R. Phatak ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Ocular Hypertension ◽  
Rat Model ◽  
Neuroprotective Effects

scholarly journals α-Aminoadipic acid protects against retinal disruption through attenuating Müller cell gliosis in a rat model of acute ocular hypertension

2016 ◽  
Vol Volume 10 ◽  
pp. 3449-3457 ◽  
Author(s):  
Xiaolei Wang ◽  
Jier Su ◽  
Jingwen Ding ◽  
Song Han ◽  
Wei Ma ◽  
...  
Keyword(s):  
Ocular Hypertension ◽  
Rat Model
Sign in / Sign up

Export Citation Format

Share Document