scholarly journals Platelet-Derived Growth Factor Preserves Retinal Synapses in a Rat Model of Ocular Hypertension

2016 ◽  
Vol 57 (3) ◽  
pp. 842 ◽  
Author(s):  
Rachel S. Chong ◽  
Andrew Osborne ◽  
Raquel Conceição ◽  
Keith R. Martin
Keyword(s):  
Growth Factor ◽  
Ocular Hypertension ◽  
Rat Model ◽  
Platelet Derived Growth Factor

scholarly journals Platelet-derived growth factor B restores vascular barrier integrity and diminishes permeability in ovarian hyperstimulation syndrome

2020 ◽  
Vol 26 (8) ◽  
pp. 585-600
Author(s):  
Natalia Pascuali ◽  
Leopoldina Scotti ◽  
Gonzalo Oubiña ◽  
Ignacio de Zúñiga ◽  
Mariana Gomez Peña ◽  
...  
Keyword(s):  
At Risk ◽  
Growth Factor ◽  
Rat Model ◽  
Ovarian Hyperstimulation Syndrome ◽  
Regulatory Protein ◽  
Platelet Derived Growth Factor ◽  
Corpora Lutea ◽  
Ovarian Hyperstimulation ◽  
Serum Progesterone ◽  
Protein Levels

Abstract Although advances in the prediction and management of ovarian hyperstimulation syndrome (OHSS) have been introduced, complete prevention is not yet possible. Previously, we and other authors have shown that vascular endothelial growth factor, angiopoietins (ANGPTs) and sphingosine-1-phosphate are involved in OHSS etiology. In addition, we have demonstrated that ovarian protein levels of platelet-derived growth factor (PDGF) ligands -B and -D decrease in an OHSS rat model, whilst PDGFR-β and ANGPT2 remain unchanged. In the present work, we investigated the role of PDGF-B in OHSS by evaluating ligand protein levels in follicular fluid (FF) from women at risk of developing OHSS and by using an immature rat model of OHSS. We demonstrated that PDGF-B and PDGF-D are lower in FF from women at risk of developing OHSS compared to control patients (P < 0.05). In the OHSS rat model, PDGF-B (0.5 µg/ovary) administration decreased ovarian weight (P < 0.05), reduced serum progesterone (P < 0.05) and lowered the percentage of cysts (P < 0.05), compared to untreated OHSS rats, but had no effect on the proportion of follicles or corpora lutea (CL). PDGF-B treatment also restored the expression of steroidogenic acute regulatory protein (P < 0.05) and P450 cholesterol side-chain cleavage enzyme (P < 0.01) to control levels. In addition, PDGF-B increased the peri-endothelial cell area in CL and cystic structures, and reduced vascular permeability compared to untreated OHSS ovaries. Lastly, PDGF-B increased the levels of junction proteins claudin-5 (P < 0.05), occludin (P < 0.05) and β-catenin (P < 0.05), while boosting the extracellular deposition of collagen IV surrounding the ovarian vasculature (PP < 0.01), compared to OHSS alone. In conclusion, our findings indicate that PDGF-B could be another crucial mediator in the onset and development of OHSS, which may lead to the development of novel prediction markers and therapeutic strategies.

scholarly journals Effect of recombinant human platelet-derived growth factor-BB-coated sutures on Achilles tendon healing in a rat model: A histological and biomechanical study

2012 ◽  
Vol 3 (1) ◽  
pp. 204173141245357 ◽  
Author(s):  
Stephen H Cummings ◽  
Daniel A Grande ◽  
Christopher K Hee ◽  
Hans K Kestler ◽  
Colleen M Roden ◽  
...  
Keyword(s):  
Growth Factor ◽  
Achilles Tendon ◽  
Rat Model ◽  
Human Platelet ◽  
Tendon Healing ◽  
Biomechanical Study ◽  
Platelet Derived Growth Factor

scholarly journals Platelet-Derived Growth Factor-AB Limits the Extent of Myocardial Infarction in a Rat Model

Circulation ◽  
2002 ◽  
Vol 105 (5) ◽  
pp. 608-613 ◽  
Author(s):  
Jay M. Edelberg ◽  
Seung H. Lee ◽  
Manmeen Kaur ◽  
Lilong Tang ◽  
Nikki M. Feirt ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Growth Factor ◽  
Rat Model ◽  
Platelet Derived Growth Factor
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