scholarly journals Bacterial Characteristics in Intestinal Contents of Antibiotic-Associated Diarrhea Mice Treated with Qiweibaizhu Powder

2020 ◽  
Vol 26 ◽  
Author(s):  
Huaying Hui ◽  
Yi Wu ◽  
Tao Zheng ◽  
Sainan Zhou ◽  
Zhoujin Tan
Keyword(s):  
Antibiotic Associated Diarrhea ◽  
Intestinal Contents

Bacteriophages Associated with Turkey Coecums in Bluecomb-Infected and Healthy Birds

1969 ◽  
Vol 27 ◽  
pp. 226-227
Author(s):  
A. E. Ritchie
Keyword(s):  
Host Cell ◽  
Causal Relationship ◽  
Cell Cultures ◽  
Cell Interaction ◽  
Etiologic Agent ◽  
Viral Origin ◽  
Intestinal Contents ◽  
Host Cell Interaction

The cause of bluecomb disease in turkeys is unknown. Filtration of infective intestinal contents suggests a viral origin. To date, it has not been possible to isolate the etiologic agent in various cell cultures. The purpose of this work was to characterize as many virus-like entities as were recognizable in intestines of both healthy and bluecomb-infected turkeys. By a comparison of the viral populations it was hoped that some insight might be gained into the cause of this disease. Studies of turkey hemorraghic enteritis by Gross and Moore (Avian Dis. 11: 296-307, 1967) have suggested that a bacteriophage-host cell interaction may bear some causal relationship to that disease.

LACTOSE-FERMENTING BACTERIA FROM THE INTESTINAL CONTENTS OF MARINE FISH

1933 ◽  
Vol 8 (1) ◽  
pp. 291-300 ◽  
Author(s):  
NORMAN E. GIBBONS
Keyword(s):  
Marine Fish ◽  
Marine Fishes ◽  
Soil Types ◽  
Intestinal Contents ◽  
Fermenting Bacteria ◽  
Relationship Of ◽  
The Relationship ◽  
Contaminated Waters

From 112 marine fishes examined for the presence of lactose-fermenting bacteria, 31 strains were isolated which produced acid and gas in this sugar and 3 which produced acid only.Ten strains belonged to the genus Aerobacter, 8 being Aer. aerogenes and 2 probably varieties of Aer. cloacae. Nine were soil types and the relationship of one was doubtful.Of 24 Escherichia types, 8 were faecal mammalian strains and one was doubtful. These belonged to the species Esch. coli, Esch. communior, Esch. grünthali and Bact. immobilis. One was found in a haddock taken 3 miles offshore; the others were found in fish taken in contaminated waters or near shore.Esch. coli, Esch. communior and Aer. aerogenes are not normal inhabitants of the intestinal tracts of marine fish.

scholarly journals Proteomic Adaptation of Clostridioides difficile to Treatment with the Antimicrobial Peptide Nisin

Cells ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 372
Author(s):  
Sandra Maaß ◽  
Jürgen Bartel ◽  
Pierre-Alexander Mücke ◽  
Rabea Schlüter ◽  
Thomas Sura ◽  
...  
Keyword(s):  
State Of The Art ◽  
Biomedical Application ◽  
Time Resolved ◽  
Antibiotic Resistant ◽  
Cellular Processes ◽  
Clostridioides Difficile ◽  
Antibiotic Associated Diarrhea ◽  
Life Threatening ◽  
Sublethal Concentrations ◽  
Interesting Alternative

Clostridioides difficile is the leading cause of antibiotic-associated diarrhea but can also result in more serious, life-threatening conditions. The incidence of C. difficile infections in hospitals is increasing, both in frequency and severity, and antibiotic-resistant C. difficile strains are advancing. Against this background antimicrobial peptides (AMPs) are an interesting alternative to classic antibiotics. Information on the effects of AMPs on C. difficile will not only enhance the knowledge for possible biomedical application but may also provide insights into mechanisms of C. difficile to adapt or counteract AMPs. This study applies state-of-the-art mass spectrometry methods to quantitatively investigate the proteomic response of C. difficile 630∆erm to sublethal concentrations of the AMP nisin allowing to follow the cellular stress adaptation in a time-resolved manner. The results do not only point at a heavy reorganization of the cellular envelope but also resulted in pronounced changes in central cellular processes such as carbohydrate metabolism. Further, the number of flagella per cell was increased during the adaptation process. The potential involvement of flagella in nisin adaptation was supported by a more resistant phenotype exhibited by a non-motile but hyper-flagellated mutant.

scholarly journals Clinical characteristics and factors related to antibiotic-associated diarrhea in elderly patients with pneumonia: a retrospective cohort study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Yoko Takedani ◽  
Tsukasa Nakamura ◽  
Noriko Fukiwake ◽  
Toshihiro Imada ◽  
Junji Mashino ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cohort Study ◽  
Elderly Patients ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Tertiary Care ◽  
Multivariate Logistic Regression Model ◽  
Care Hospital ◽  
Antibiotic Associated Diarrhea ◽  
Elderly Inpatients

Abstract Background Antibiotic-associated diarrhea (AAD) is a common problem among elderly inpatients because many elderly patients are admitted for pneumonia or other conditions that necessitate antibiotic treatment. In the super aging population, more patients are suffering from pneumonia than before, but the incidence or risk factors for AAD among many elderly patients have not been well scrutinized. Methods We conducted a retrospective cohort study of elderly patients diagnosed with pneumonia from April 2014 to March 2019 who were admitted to the Department of General Medicine of a Tertiary Care Hospital in Japan. Patients (≥ 65 years of age) who were diagnosed with bacterial pneumonia or aspiration pneumonia and treated with antibiotics were included. We defined AAD by diarrhea with more than three loose or watery stools per day and included patients who had these symptoms for either one day or two or more consecutive days. We also assessed the length of hospital stay and in-hospital mortality. The potential risk factors for AAD included age, sex, body weight, body mass index, smoking, alcohol, activities of daily living (ADL),　comorbidities, vital signs, laboratories, the severity of pneumonia, antibiotic and other medication use. Results There were 1,067 patients, the mean age was 83 years, and men accounted for 59 %. β-Lactamase inhibitors were frequently prescribed antibiotics in 703 patients (66 %), and proton pump inhibitors (PPIs) were also commonly administered (48 %). AAD developed in 322 patients (30 %). The multivariate logistic regression model showed that β-lactamase inhibitors (OR 1.43, 95 % CI 1.05–1.95) and PPIs (OR 1.37, 95 % CI 1.03–1.83) were associated with AAD as well as age (OR 1.03 per year, 95 % CI 1.01–1.05). Conclusions AAD was common among elderly inpatients with pneumonia, and β-lactamase inhibitors and PPIs were associated with AAD. Strict use of such medication should be considered to decrease the risk of AAD.

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