scholarly journals MiR-323-3p Targeting Transmembrane Protein with EGF-Like and 2 Follistatin Domain (TMEFF2) Inhibits Human Lung Cancer A549 Cell Apoptosis by Regulation of AKT and ERK Signaling Pathways

2020 ◽  
Vol 26 ◽  
Author(s):  
Ji-min Fan ◽  
Zheng-rong Zheng ◽  
Yi-Ming Zeng ◽  
Xiao-yang Chen
Keyword(s):  
Lung Cancer ◽  
Signaling Pathways ◽  
A549 Cell ◽  
Cell Apoptosis ◽  
Human Lung ◽  
Transmembrane Protein ◽  
Erk Signaling ◽  
Human Lung Cancer ◽  
Lung Cancer A549 Cell

scholarly journals Human Pituitary Tumor Transforming Gene (hPTTG) Inhibits Human Lung Cancer A549 Cell Growth through Activation of p21WAF1/CIP1

2003 ◽  
Vol 50 (6) ◽  
pp. 771-781 ◽  
Author(s):  
Yi-Ming MU ◽  
Koichi OBA ◽  
Toshihiko YANASE ◽  
Takeshi ITO ◽  
Kenji ASHIDA ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cell Growth ◽  
A549 Cell ◽  
Pituitary Tumor ◽  
Human Lung ◽  
Human Lung Cancer ◽  
Human Pituitary ◽  
Transforming Gene ◽  
Lung Cancer A549 Cell ◽  
Human Pituitary Tumor

Proteomic analysis of the effect ofAntrodia camphorata extract on human lung cancer A549 cell

PROTEOMICS ◽  
2006 ◽  
Vol 6 (3) ◽  
pp. 826-835 ◽  
Author(s):  
Hung Wu ◽  
Ching-Liang Pan ◽  
Yun-Chin Yao ◽  
Shau-Shin Chang ◽  
Shun-Lai Li ◽  
...  
Keyword(s):  
Lung Cancer ◽  
A549 Cell ◽  
Proteomic Analysis ◽  
Human Lung ◽  
Human Lung Cancer ◽  
Lung Cancer A549 Cell

scholarly journals Kaempferide Induces G0/G1 Phase Arrest and Apoptosis via ROS-Mediated Signaling Pathways in A549 Human Lung Cancer Cells

2020 ◽  
Vol 15 (7) ◽  
pp. 1934578X2093522
Author(s):  
Hong-Liang Li ◽  
Shu-Mei Li ◽  
Ying-Hua Luo ◽  
Wan-Ting Xu ◽  
Yu Zhang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cell Cycle ◽  
Signaling Pathways ◽  
Cell Apoptosis ◽  
Human Lung ◽  
A549 Cells ◽  
Human Lung Cancer ◽  
Expression Levels ◽  
Cycle Arrest ◽  
Human Lung Cancer Cells

Kaempferide is an O-methylated flavonol that has received much attention due to its various biological activities. In this study, we explored the underlying mechanisms of kaempferide in human lung cancer A549 cells. The Cell Counting Kit-8 (CCK-8) assay, Hoechst 33342/propidium iodide double staining, flow cytometry, scratch wound healing assay, and Western blot analysis were used to measure cell apoptosis, the cell cycle, reactive oxygen species (ROS) levels, and cell migration of human lung cancer cells. Kaempferide significantly inhibited human lung cancer cell proliferation, and its toxic effects on normal cells were significantly lower than those of 5-fluorouracil. Kaempferide induced A549 cell apoptosis by decreasing the mitochondrial membrane potential and the expression level of B-cell lymphoma 2, and by increasing the expression levels of Bcl-2-associated X protein and caspase-3. It also regulated mitogen-activated protein kinase (MAPK), signal transducer and activator of transcription 3 (STAT3), and nuclear factor kappa B (NF-κB) signaling pathways by increasing the expression levels of phosphorylated c-Jun N-terminal kinase, p-p38, I kappa B, and by decreasing the expression levels of phosphorylated extracellular signal-regulated kinase, p-STAT3, and NF-κB. Kaempferide induced cell cycle arrest in the G0/G1 phase in A549 cells by downregulating the expression levels of p-AKT, cyclin D1, and cyclin-dependent kinase 2. Furthermore, kaempferide blocked A549 cell migration by downregulating the expression levels of transforming growth factor beta 1 (TGF-β1), p-β-catenin, p-glycogen synthase kinase 3 beta, N-cadherin, and vimentin, and by upregulating the expression level of E-cadherin. Kaempferide enhanced the accumulation of ROS, and N-acetyl-l-cysteine (a ROS inhibitor) decreased the regulation of MAPK, NF-κB, AKT, and TGF-β signaling pathways by kaempferide, inhibited cell apoptosis, and reversed cell cycle arrest. Our results showed that kaempferide induced apoptosis via ROS-mediated MAPK, NF-κB, AKT, and TGF-β signaling pathways in A549 cells. Thus, kaempferide may be a novel drug candidate for lung cancer.

scholarly journals Promising Anticancer Effect of Aurisin A Against the Human Lung Cancer A549 Cell Line

2020 ◽  
Vol 21 (1) ◽  
pp. 49-54
Author(s):  
Parichart Boueroy ◽  
Thidarut Boonmars ◽  
Somdej Kanokmedhakul ◽  
Sorujsiri Chareonsudjai ◽  
Ratsami Lekphrom ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cell Line ◽  
A549 Cell ◽  
Human Lung ◽  
Human Lung Cancer ◽  
A549 Cell Line ◽  
Anticancer Effect ◽  
Lung Cancer A549 Cell

Anticancer effect of the water extract of a commercial Spirulina (Arthrospira platensis) product on the human lung cancer A549 cell line

2018 ◽  
Vol 106 ◽  
pp. 292-302 ◽  
Author(s):  
Arkadiusz Czerwonka ◽  
Katarzyna Kaławaj ◽  
Adrianna Sławińska-Brych ◽  
Marta K. Lemieszek ◽  
Magdalena Bartnik ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cell Line ◽  
A549 Cell ◽  
Human Lung ◽  
Water Extract ◽  
Arthrospira Platensis ◽  
Human Lung Cancer ◽  
A549 Cell Line ◽  
Anticancer Effect ◽  
Lung Cancer A549 Cell

scholarly journals A Ferulic Acid Derivative FXS-3 Inhibits Proliferation and Metastasis of Human Lung Cancer A549 Cells via Positive JNK Signaling Pathway and Negative ERK/p38, AKT/mTOR and MEK/ERK Signaling Pathways

Molecules ◽  
2019 ◽  
Vol 24 (11) ◽  
pp. 2165 ◽  
Author(s):  
Shi-Jun Yue ◽  
Peng-Xuan Zhang ◽  
Yue Zhu ◽  
Nian-Guang Li ◽  
Yan-Yan Chen ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Signaling Pathways ◽  
Human Lung ◽  
A549 Cells ◽  
Erk Signaling ◽  
Human Lung Cancer ◽  
Jnk Signaling ◽  
Anti Cancer ◽  
Proliferation And Metastasis ◽  
Jnk Signaling Pathway

Lung cancer is one of the most common malignancies and is an increasing cause of cancer-related deaths. In our previous study, a series of ferulic acid (FA) derivatives were designed and synthesized; they exhibited positive anti-cancer activities, especially for a compound labelled FXS-3. In this study, a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay was performed, wherein it revealed the inhibitory effect of FXS-3 on the proliferation and metastasis of human lung cancer A549 cells. The further flow cytometry assay showed that FXS-3 induced apoptosis of A549 cells induced cell cycle arrest at the G0/G1 phase. The trans-well migration and Matrigel invasion assays revealed that FXS-3 inhibited the migration and invasion of A549 cells. By the western blotting analysis, FXS-3 increased the expression of B-cell lymphoma-2 (Bcl-2) associated X protein (Bax)/Bcl-2 ratio, inhibited matrix metalloproteinase (MMP)-2 and MMP-9, and regulated the extracellular signal-regulated kinase (ERK)/p38, c-Jun N-terminal kinase (JNK), protein kinase B (AKT)/mechanistic target of rapamycin (mTOR), as well as mitogen-activated protein kinase (MEK)/ERK signaling pathways. The subsequent A549 xenograft-bearing mouse model and tail vein injection of A549 cells induced pulmonary tumor metastasis model showed that FXS-3 significantly restrained the tumor growth and metastasis. In conclusion, FXS-3 might inhibit proliferation and metastasis of human lung cancer A549 cells by positively regulating JNK signaling pathway and negativly regulating ERK/p38, AKT/mTOR, and MEK/ERK signaling pathways, which provides important scientific basis for the development of anti-cancer drugs about FA derivatives.

scholarly journals Draft genome sequence data of Streptomyces sp. SS1-1, an endophytic strain showing cytotoxicity against the human lung cancer A549 cell line

Data in Brief ◽  
2020 ◽  
Vol 30 ◽  
pp. 105497
Author(s):  
Quan Dang Nguyen ◽  
Phung Minh Truong ◽  
Thao Nguyen Thanh Vo ◽  
Truc Dao Xuan Chu ◽  
Chuong Hoang Nguyen
Keyword(s):  
Lung Cancer ◽  
Cell Line ◽  
A549 Cell ◽  
Human Lung ◽  
Sequence Data ◽  
Draft Genome ◽  
Human Lung Cancer ◽  
A549 Cell Line ◽  
Streptomyces Sp ◽  
Lung Cancer A549 Cell
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