Induction of Human-Lung-Cancer-A549-Cell Apoptosis by 4-Hydroperoxy-2-decenoic Acid Ethyl Ester through Intracellular ROS Accumulation and the Induction of Proapoptotic CHOP Expression

2018 ◽  
Vol 66 (41) ◽  
pp. 10741-10747 ◽  
Author(s):  
Tetsuro Kamiya ◽  
Momoko Watanabe ◽  
Hirokazu Hara ◽  
Yukari Mitsugi ◽  
Eiji Yamaguchi ◽  
...  
Keyword(s):  
Lung Cancer ◽  
A549 Cell ◽  
Human Lung ◽  
Acid Ethyl Ester ◽  
Human Lung Cancer ◽  
Decenoic Acid ◽  
Chop Expression ◽  
Ros Accumulation ◽  
Intracellular Ros ◽  
Lung Cancer A549 Cell

scholarly journals Human Pituitary Tumor Transforming Gene (hPTTG) Inhibits Human Lung Cancer A549 Cell Growth through Activation of p21WAF1/CIP1

2003 ◽  
Vol 50 (6) ◽  
pp. 771-781 ◽  
Author(s):  
Yi-Ming MU ◽  
Koichi OBA ◽  
Toshihiko YANASE ◽  
Takeshi ITO ◽  
Kenji ASHIDA ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cell Growth ◽  
A549 Cell ◽  
Pituitary Tumor ◽  
Human Lung ◽  
Human Lung Cancer ◽  
Human Pituitary ◽  
Transforming Gene ◽  
Lung Cancer A549 Cell ◽  
Human Pituitary Tumor

Proteomic analysis of the effect ofAntrodia camphorata extract on human lung cancer A549 cell

PROTEOMICS ◽  
2006 ◽  
Vol 6 (3) ◽  
pp. 826-835 ◽  
Author(s):  
Hung Wu ◽  
Ching-Liang Pan ◽  
Yun-Chin Yao ◽  
Shau-Shin Chang ◽  
Shun-Lai Li ◽  
...  
Keyword(s):  
Lung Cancer ◽  
A549 Cell ◽  
Proteomic Analysis ◽  
Human Lung ◽  
Human Lung Cancer ◽  
Lung Cancer A549 Cell

scholarly journals Promising Anticancer Effect of Aurisin A Against the Human Lung Cancer A549 Cell Line

2020 ◽  
Vol 21 (1) ◽  
pp. 49-54
Author(s):  
Parichart Boueroy ◽  
Thidarut Boonmars ◽  
Somdej Kanokmedhakul ◽  
Sorujsiri Chareonsudjai ◽  
Ratsami Lekphrom ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cell Line ◽  
A549 Cell ◽  
Human Lung ◽  
Human Lung Cancer ◽  
A549 Cell Line ◽  
Anticancer Effect ◽  
Lung Cancer A549 Cell

Anticancer effect of the water extract of a commercial Spirulina (Arthrospira platensis) product on the human lung cancer A549 cell line

2018 ◽  
Vol 106 ◽  
pp. 292-302 ◽  
Author(s):  
Arkadiusz Czerwonka ◽  
Katarzyna Kaławaj ◽  
Adrianna Sławińska-Brych ◽  
Marta K. Lemieszek ◽  
Magdalena Bartnik ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cell Line ◽  
A549 Cell ◽  
Human Lung ◽  
Water Extract ◽  
Arthrospira Platensis ◽  
Human Lung Cancer ◽  
A549 Cell Line ◽  
Anticancer Effect ◽  
Lung Cancer A549 Cell

scholarly journals Draft genome sequence data of Streptomyces sp. SS1-1, an endophytic strain showing cytotoxicity against the human lung cancer A549 cell line

Data in Brief ◽  
2020 ◽  
Vol 30 ◽  
pp. 105497
Author(s):  
Quan Dang Nguyen ◽  
Phung Minh Truong ◽  
Thao Nguyen Thanh Vo ◽  
Truc Dao Xuan Chu ◽  
Chuong Hoang Nguyen
Keyword(s):  
Lung Cancer ◽  
Cell Line ◽  
A549 Cell ◽  
Human Lung ◽  
Sequence Data ◽  
Draft Genome ◽  
Human Lung Cancer ◽  
A549 Cell Line ◽  
Streptomyces Sp ◽  
Lung Cancer A549 Cell

scholarly journals Synthesis, In Vitro Anticancer Activity and In Silico Study of some Benzylidene Hydrazide Derivatives

2020 ◽  
Vol 840 ◽  
pp. 277-283
Author(s):  
Melanny Ika Sulistyowaty ◽  
Galih Satrio Putra ◽  
Tutuk Budiati ◽  
Katsuyoshi Matsunami
Keyword(s):  
Cell Line ◽  
A549 Cell ◽  
In Silico ◽  
Protein Tyrosine Kinase ◽  
Human Lung ◽  
Human Lung Cancer ◽  
A549 Cell Line ◽  
Mtt Method ◽  
Lung Cancer A549 Cell

Some benzylidenehydrazides (3a-e) have been synthesized in three reaction steps from anthranilic acid in good yields, about 70% - 99%. The structures of the synthesized compounds were analyzed using spectroscopic methods. The compounds were evaluated its activity against human lung cancer, A549 cell line by MTT method and studied its molecular docking onto the protein tyrosine kinase (PDB ID: 1M17) by using Molegro® vs. 5.5. The data showed that N-(2-(2-(4-nitrobenzylidene)hydrazinecarbonyl)phenyl)benzamide (3d) which synthesized in 70% yield and has the highest activity on inhibiting the growth of A549 cell line with IC50 10.9μg/mL, which was linier with our in silico study. Compound 3d has the smallest RS value -94.44 kcal/mol, lower than selected Ligand, Erlotinib.

Heat Shock Protein 27, a Novel Regulator of Transforming Growth Factor β Induced Resistance to Cisplatin in A549 Cell

Pharmacology ◽  
2017 ◽  
Vol 100 (5-6) ◽  
pp. 283-291 ◽  
Author(s):  
Zhicheng Huang ◽  
Changliang Yang ◽  
Shuangyan Sun ◽  
Yingji Nan ◽  
Zhiguo Lang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Cell ◽  
A549 Cell ◽  
Transforming Growth Factor ◽  
Human Lung ◽  
Cisplatin Resistance ◽  
Transforming Growth Factor Β ◽  
Human Lung Cancer ◽  
Lung Cancer Cell ◽  
Lung Cancer Patients

Lung cancer is one of the major causes of cancer morbidity and mortality around the world, and the resistance to cisplatin is a critical issue to chemotherapy in lung cancer patients. Transforming growth factor β (TGF-β) signal pathway abnormality is widely observed in drug resistance during lung cancer chemotherapy. Here, we investigated the effects of heat-shock protein 27 (HSP27) in the TGF-β-induced cisplatin resistance in lung cancer cell. In this study, our results indicated that the mRNA and protein expression of HSP27 were significantly increased in human lung cancer tissues. TGF-β induced the mRNA and protein expression of HSP27 in human lung cancer cell (A549). Treatment of TGF-β-induced cisplatin resistance in A549 cell through blocking the cisplatin-induced apoptosis and cell death, which characterized as the increasing of cell viability and decreasing of PARP and caspase3 cleavage in the cisplatin-treated cell. Knockdown of SMAD3 attenuated the TGF-β-induced HSP27 expression and restored the TGF-β-induced cisplatin resistance in A549 cell. Additionally, the knockdown of HSP27 blocked TGF-β-induced cisplatin resistance via decreasing cell viability and increasing cell apoptosis in A549 cell. These data therefore suggested that HSP27 is critical to lung cancer progression and TGF-β-induced cisplatin resistance in human lung cancer cell, and may provide an effective clinical strategy in lung cancer patients with resistance to chemotherapy.

A novel protein from Eupolyphaga sinensis inhibits adhesion, migration, and invasion of human lung cancer A549 cells

2013 ◽  
Vol 91 (4) ◽  
pp. 244-251 ◽  
Author(s):  
Feng-xia Wang ◽  
Ning Wu ◽  
Jian-teng Wei ◽  
Jia Liu ◽  
Jin Zhao ◽  
...  
Keyword(s):  
Lung Cancer ◽  
A549 Cell ◽  
High Performance ◽  
Human Lung ◽  
Gel Filtration ◽  
A549 Cells ◽  
Human Lung Cancer ◽  
Migration And Invasion ◽  
Fast Flow ◽  
Novel Protein

Eupolyphaga sinensis Walker is an important insect used in Chinese traditional medicine. In this study, we purified a 72-kDa anticancer protein, designated as EPS72, from this species using ammonium sulfate precipitation, ultrafiltration, CM Sepharose Fast Flow cation exchange, Q Sepharose High Performance (HP) anion exchange, Butyl Sepharose HP hydrophobic chromatography, and Superdex 75 gel filtration chromatographic techniques. EPS72 exhibited a potent anticancer activity against the human lung cancer A549 cell line (IC50, 18.76 μg/mL). Further study showed that EPS72 could induce A549 cell detachment and apoptosis, inhibit cell adhesion to fibronectin and collagen IV, and restrain cell migration and invasion. Moreover, EPS72 significantly decreased the expression of β1-integrin. This study suggests that EPS72 could potentially be developed as a novel anticancer therapeutic agent due to its possible antimetastatic activity.

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