scholarly journals Genetic Relationship Between Endothelin-1 Gene Polymorphisms and Intracerebral Hemorrhage Among Chinese Han People

2020 ◽  
Vol 26 ◽  
Author(s):  
Wanzeng Zhang ◽  
Wangmiao Zhao ◽  
Chunyan Ge ◽  
Xiaowei Li ◽  
Xuehui Yang ◽  
...  
Keyword(s):  
Intracerebral Hemorrhage ◽  
Genetic Relationship ◽  
Gene Polymorphisms ◽  
Chinese Han ◽  
Endothelin 1 ◽  
Chinese Han People

scholarly journals Genetic association of TOLLIP gene polymorphisms and HIV infection: a case-control study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Ming-Gui Wang ◽  
Jing Wang ◽  
Jian-Qing He
Keyword(s):  
Hiv Infection ◽  
Gene Polymorphisms ◽  
Case Control Study ◽  
Binary Logistic Regression ◽  
Case Control ◽  
Additive Models ◽  
Chinese Han ◽  
Interacting Protein ◽  
Control Study ◽  
Age And Sex

Abstract Background Previous studies have indicated that host genetic factors play an essential role in immunity to human immunodeficiency virus (HIV) infection. We aimed to investigate the association between the toll-interacting protein (TOLLIP) and mannose-binding lectin 2 (MBL2) genes and HIV infection susceptibility among Chinese Han patients. Methods This is a case-control study. A total of 435 HIV-infected patients and 1013 seronegative healthy individuals were recruited. DNA was extracted from whole blood. Two SNPs in the MBL2 gene (rs7096206 and rs1800450) and three SNPs in the TOLLIP gene (rs5743899, rs3750920, and rs5743867) were selected and genotyped using a SNPscan Kit (Cat#: G0104, Genesky Biotechnologies Inc., Shanghai, China). Odds ratios (ORs) and their 95% confidence intervals (CIs) were calculated using unconditional binary logistic regression. Results A significant association between the minor alleles rs5743899 (C allele) and rs5743867 (G allele) in the TOLLIP gene and susceptibility to HIV infection was found in this study after adjusting for age and sex (Pa = 0.011 and < 0.001, respectively). The rs5743867 in the TOLLIP gene was significantly associated with the risk of HIV infection in dominant, recessive, and additive models when adjusted for age and sex (Pa < 0.05). No significant association was found between MBL2 gene polymorphisms and HIV infection. Conclusion Our study found a statistically significant association between the two SNPs (rs5743867 and rs5743899) in the TOLLIP gene and susceptibility to HIV infection in a Chinese Han population.

scholarly journals Association of interleukin-18 gene polymorphisms with Takayasu arteritis in a Chinese Han population

2020 ◽  
Vol 133 (19) ◽  
pp. 2315-2320
Author(s):  
Dan Wen ◽  
Xian-Liang Zhou ◽  
Xin Du ◽  
Jian-Zeng Dong ◽  
Chang-Sheng Ma
Keyword(s):  
Takayasu Arteritis ◽  
Gene Polymorphisms ◽  
Chinese Han Population ◽  
Interleukin 18 ◽  
Chinese Han ◽  
Han Population

Interactions of Lymphotoxin α (TNF-β), Angiotensin-Converting Enzyme (ACE), and Endothelin-1 (ET-1) Gene Polymorphisms in Adult Periodontitis

2001 ◽  
Vol 72 (1) ◽  
pp. 85-89 ◽  
Author(s):  
Lydie Izakovičová Hollá ◽  
Antonín Fassmann ◽  
Anna Vašků ◽  
Vladimír Znojil ◽  
Jiří Vaněk ◽  
...  
Keyword(s):  
Angiotensin Converting Enzyme ◽  
Gene Polymorphisms ◽  
Converting Enzyme ◽  
Endothelin 1 ◽  
Lymphotoxin Α

scholarly journals Association between BMP4 gene polymorphisms and eyelid traits in Chinese Han population

2017 ◽  
Vol 6 ◽  
pp. e355-e356 ◽  
Author(s):  
Qian Wang ◽  
Bo Jin ◽  
Xiaoying Luo ◽  
Tao Feng ◽  
Yu Xia ◽  
...  
Keyword(s):  
Gene Polymorphisms ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population

scholarly journals Impact of polymorphisms in DNA repair genes XPD, hOGG1 and XRCC4 on colorectal cancer risk in a Chinese Han Population

2019 ◽  
Vol 39 (1) ◽  
Author(s):  
Dexi Jin ◽  
Min Zhang ◽  
Hongjun Hua
Keyword(s):  
Colorectal Cancer ◽  
Gene Polymorphisms ◽  
Colorectal Carcinogenesis ◽  
Chinese Han Population ◽  
Control Group ◽  
Chinese Han ◽  
Han Population ◽  
Increased Risk ◽  
Hogg1 Gene ◽  
Repair Genes

Abstract Background: This research aimed to study the associations between XPD (G751A, rs13181), hOGG1 (C326G, rs1052133) and XRCC4 (G1394T, rs6869366) gene polymorphisms and the risk of colorectal cancer (CRC) in a Chinese Han population. Method: A total of 225 Chinese Han patients with CRC were selected as the study group, and 200 healthy subjects were recruited as the control group. The polymorphisms of XPD G751A, hOGG1 C326G and XRCC4 G1394T loci were detected by the RFLP-PCR technique in the peripheral blood of all subjects. Results: Compared with individuals carrying the XPD751 GG allele, the A allele carriers (GA/AA) had a significantly increased risk of CRC (adjusted OR = 2.109, 95%CI = 1.352–3.287, P=0.003). Similarly, the G allele (CG/GG) of hOGG1 C326G locus conferred increased susceptibility to CRC (adjusted OR = 2.654, 95%CI = 1.915–3.685, P<0.001). In addition, the T allele carriers (GT/TT) of the XRCC4 G1394T locus have an increased risk of developing CRC (adjusted OR = 4.512, 95%CI = 2.785–7.402, P<0.001). The risk of CRC was significantly increased in individuals with both the XPD locus A allele and the hOGG1 locus G allele (adjusted OR = 1.543, 95%CI = 1.302–2.542, P=0.002). Furthermore, individuals with both the hOGG1 locus G allele and the XRCC4 locus T allele were predisposed to CRC development (adjusted OR = 3.854, 95%CI = 1.924–7.123, P<0.001). The risks of CRC in XPD gene A allele carriers (GA/AA) (adjusted OR = 1.570, 95%CI = 1.201–1.976, P=0.001), hOGG1 gene G allele carriers (CG/GG) (adjusted OR = 3.031, 95%CI = 2.184–4.225, P<0.001) and XRCC4 gene T allele carriers (GT/TT) (adjusted OR = 2.793, 95%CI = 2.235–3.222, P<0.001) were significantly higher in patients who smoked ≥16 packs/year. Conclusion: Our results suggest that XPD G751A, hOGG1 C326G and XRCC4 G1394T gene polymorphisms might play an important role in colorectal carcinogenesis and increase the risk of developing CRC in the Chinese Han population. The interaction between smoking and these gene polymorphisms would increase the risk of CRC.

Sign in / Sign up

Export Citation Format

Share Document