scholarly journals A Single-Nucleotide Polymorphism (rs1131243) of the Transforming Growth Factor Beta Signaling Pathway Contributes to Risk of Acute Rejection in Chinese Renal Transplant Recipients

2019 ◽  
Vol 25 ◽  
pp. 9138-9158
Author(s):  
Ming Zheng ◽  
Haiwei Yang ◽  
Wencheng Li ◽  
Jiajun Zhou ◽  
Jintao Wei ◽  
...  
Keyword(s):  
Single Nucleotide Polymorphism ◽  
Growth Factor ◽  
Renal Transplant ◽  
Transforming Growth Factor Beta ◽  
Transforming Growth Factor ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
Nucleotide Polymorphism ◽  
Single Nucleotide ◽  
Growth Factor Beta

scholarly journals Association of TGF-β2 Gene Polymorphism with Salmonella pullorum Bacterial Infection Resistance in Tolaki Chickens

2020 ◽  
pp. 46-54
Author(s):  
Muh Akramullah ◽  
Cece Sumantri ◽  
Niken Ulupi
Keyword(s):  
Single Nucleotide Polymorphism ◽  
Growth Factor ◽  
Bacterial Infection ◽  
Nucleotide Polymorphism ◽  
Single Nucleotide ◽  
Infection Resistance ◽  
Salmonella Pullorum ◽  
Growth Factor Beta ◽  
Beta 2 ◽  
Leucocyte Concentration

Transformation growth factor-beta 2 gene (TGF-β2) is a gene which belongs to the cytokine gene group. The present study aimed to identify Single Nucleotide Polymorphism (SNP) g. 640 T> C of Transformation growth factor-beta 2 gene (TGF-β2) and associate its genotypes with Salmonella pullorum Bacterial Infection Resistance in Tolaki Chickens. This study used blood samples collected from 70 chickens. Discussion was conducted on leucocyte concentration, leucocyte differentiation (heterophils, monocytes, lymphocytes, eosinophils, basophils and H/L ratio) and clearance test. Identification of Single Nucleotide Polymorphism of Transformation growth factor-beta 2 gene (TGF-β2) was performed by PCR-RFLP method. Association of (SNP) g. 640 T> C of Transformation growth factor-beta 2 gene (TGF-β2) with leukocyte profiles and their differentiation and resistance to bacterial infections was carried out using analysis of variance with GLM (General Linear Model). SNP g.640 T> C of Transformation growth factor-beta 2 gene (TGF-β2) was polymorphic and was in Hardy-Weinberg equilibrium. Based on molecular and biological testing, Tolaki chickens in genotypes (TT, TC and CC) have normal leucocyte concentration and differenciation and resistant to Salmonella pullorum.

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