scholarly journals Serum Cystatin C and Arterial Stiffness in Middle-Aged and Elderly Adults without Chronic Kidney Disease: A Population-Based Study

2019 ◽  
Vol 25 ◽  
pp. 9207-9215
Author(s):  
Xiaolin Huang ◽  
Xiaohong Jiang ◽  
Long Wang ◽  
Zhenyu Liu ◽  
Yang Wu ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Arterial Stiffness ◽  
Cystatin C ◽  
Population Based ◽  
Elderly Adults ◽  
Middle Aged ◽  
Serum Cystatin C ◽  
Population Based Study ◽  
Serum Cystatin

P0737THE ASSOCIATION BETWEEN CYSTATIN C AND ARTERIAL STIFFNESS IN NON-CKD PATIENTS

2020 ◽  
Vol 35 (Supplement_3) ◽  
Author(s):  
Nejc Piko ◽  
Tadej Petreski ◽  
Robert Ekart ◽  
Radovan Hojs ◽  
Sebastjan Bevc
Keyword(s):  
Diabetes Mellitus ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Myocardial Perfusion ◽  
Arterial Stiffness ◽  
Arterial Hypertension ◽  
Cystatin C ◽  
Laboratory Data ◽  
Applanation Tonometry ◽  
Serum Cystatin C

Abstract Background and Aims Serum cystatin C (cysC) is produced by all nucleated cells at a constant rate, is filtered freely by the glomerulus and metabolized after tubular reabsorption. It is influenced less by age, gender and muscle mass compared to serum creatinine. These properties make it an important marker in detecting renal impairment. Arterial stiffness is a hallmark of atherosclerosis and is connected to cardiovascular events and mortality. In patients with chronic kidney disease (CKD), cysC correlates with increased arterial stiffness, but less is known about the association between cysC and arterial stiffness in non-CKD patients. Method The study was performed at the University Medical Centre Maribor between October 1st 2018 and January 1st 2020. Basic demographic and laboratory data were recorded. To estimate glomerular filtration rate (eGFR), Chronic Kidney Disease Epidemiology (CKD-EPI) equation was used. Patients with previously diagnosed CKD and/or eGFR ≤ 60 ml/min/1.73m2 at the time of admission, known malignancy, thyroid disease and/or on steroid therapy were not enrolled in the study. Arterial stiffness was measured with applanation tonometry (Sphygmocor®, Australia), carotid-femoral pulse wave velocity (cfPWV) was used as the gold standard of central arterial stiffness and subendocardial viability ratio (SEVR) was used as the marker of myocardial perfusion. SPSS® version 22 was used for statistical analysis. Results 111 patients (65.8% male, average age 64.3±9.4 years) were included in our study. Most common comorbidities were arterial hypertension (n=86, 77.5%), hyperlipidaemia (n=64, 57.7%) and diabetes mellitus (n=22, 19.8%). Mean creatinine value was 77.7±13.8 μmol/L (range 49-108 μmol/L), mean eGFR was 81.3±9.4 ml/min/1.73m2 (range 62-90 ml/min/1.73m2) and mean value of cysC was 0.94±0.18 mg/L (range 0.67-1.63 mg/L). Mean SEVR value was 165.7±36.1% (range 92-299%) and mean cfPWV value was 10.1±2.4 m/s (range 6.2-16.8 m/s). Significant correlation was found between cysC and SEVR (r=-0.316, p<0.001) and between cysC and cfPWV (r=0.472, p<0.001). Multiple regression analysis of arterial stiffness indices and cysC, age, gender, diabetes mellitus, arterial hypertension, eGFR and hyperlipidemia, showed statistically significant association between cysC and cfPWV (ß=0.220, p=0.038) and cysC and SEVR (ß=-0.278, p=0.017). Conclusion Serum cysC is independently associated with increased arterial stiffness, reduced myocardial perfusion and increased cardiovascular risk in non-CKD patients.

scholarly journals Expressing the CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration) Cystatin C Equations for Estimating GFR With Standardized Serum Cystatin C Values

2011 ◽  
Vol 58 (4) ◽  
pp. 682-684 ◽  
Author(s):  
Lesley A. Inker ◽  
John Eckfeldt ◽  
Andrew S. Levey ◽  
Catherine Leiendecker-Foster ◽  
Gregory Rynders ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Cystatin C ◽  
Serum Cystatin C ◽  
Serum Cystatin ◽  
Disease Epidemiology

scholarly journals Serum Cystatin C - Marker of Inflammation and Cardiovascular Morbidity in Chronic Kidney Disease Stages 1-4

2015 ◽  
Vol 27 (2) ◽  
pp. 75 ◽  
Author(s):  
Alma Muslimovic ◽  
Denijal Tulumovic ◽  
Senad Hasanspahic ◽  
Aida HamzicMehmedbasic ◽  
Ramajana Temimovic
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Cystatin C ◽  
Cardiovascular Morbidity ◽  
Serum Cystatin C ◽  
Serum Cystatin ◽  
Disease Stages

scholarly journals Serum cystatin C levels are associated with coronary artery calcification in women without chronic kidney disease

2017 ◽  
Vol 70 (6) ◽  
pp. 559-564 ◽  
Author(s):  
Hiroyasu Sugiyama ◽  
Toru Miyoshi ◽  
Kazuhiro Osawa ◽  
Takashi Miki ◽  
Yuji Koide ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Coronary Artery ◽  
Kidney Disease ◽  
Cystatin C ◽  
Coronary Artery Calcification ◽  
Serum Cystatin C ◽  
Serum Cystatin

scholarly journals Comparison of Chronic Kidney Disease Epidemiology Collaboration Equations with Other Accepted Equations for Estimation of Glomerular Filtration Rate in Indian Chronic Kidney Disease Patients

2017 ◽  
Vol 16 (2) ◽  
pp. 238-244
Author(s):  
Kumaresan Ramanathan ◽  
Giri Padmanabhan
Keyword(s):  
Chronic Kidney Disease ◽  
Glomerular Filtration Rate ◽  
Kidney Disease ◽  
Serum Creatinine ◽  
Cystatin C ◽  
Filtration Rate ◽  
Serum Cystatin C ◽  
Serum Cystatin ◽  
Disease Epidemiology ◽  
Measured Gfr

Background and Aim: In routine clinical practice, the estimation of glomerular filtration rate (GFR) based on serum creatinine has been followed. However, the reliability of creatinine in estimation of GFR is biased and imprecise, leading to the misdiagnosis of chronic kidney disease (CKD). The serum cystatin C is an alternative marker for estimating GFR. Hence, we aimed to compare the newly proposed Chronic Kidney Disease Epidemiology Collaboration Equations (CKD-EPI) with four approved equations based on both creatinine and cystatin C with reference to Tc-99m-diethylenetriamine pentaacetate (Tc-99m-DTPA) considered as a standard.Materials and Methods:Two hundred and one patients were enrolled in the study from a private nephrology outpatient clinic(OPD), Tiruchirappalli, India. The serum creatinine and cystatin C were measured along with routine biochemistry tests. The measurement of GFR was done by Tc-99m-DTPA gates method. The estimated GFR (eGFR) were calculated using serum cystatin C and creatinine based formulae along with the new CKD-EPI formulae. All eGFR estimations were compared with the measured GFR by gates method.Results: The average measured GFR of end stage, severe, moderate, mild renal disease and normal patient groups were 10.17±2.47, 22.58±4.40, 39.05±7.06, 69.62±24.64 and 118.06±29.23 respectively. When comparing the diagnostic accuracy for predicting GFR using well established formulae, the cystatin C based formulae have shown to be highly accurate in all stages of CKD than creatinine based formulae. Among cystatin C based formulae, CKD-EPI Cystatin C had relatively better diagnostic accuracy for predicting GFR in all stages of CKD.Conclusion: CKD-EPI Cystatin C formula has unbiased and more accurate to predict GFR in all stages of CKD.Bangladesh Journal of Medical Science Vol.16(2) 2017 p.238-244

scholarly journals Serum cystatin C is an independent biomarker associated with the renal resistive index in patients with chronic kidney disease

PLoS ONE ◽  
2018 ◽  
Vol 13 (3) ◽  
pp. e0193695 ◽  
Author(s):  
Ayu Ogawa-Akiyama ◽  
Hitoshi Sugiyama ◽  
Masashi Kitagawa ◽  
Keiko Tanaka ◽  
Akifumi Onishi ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Cystatin C ◽  
Resistive Index ◽  
Renal Resistive Index ◽  
Serum Cystatin C ◽  
Serum Cystatin

The clinical research on serum cystatin-C alteration on stage II chronic kidney disease with gubenquduyishen decoction treatment

2010 ◽  
Vol 131 (3) ◽  
pp. 581-584 ◽  
Author(s):  
Feixia Dong ◽  
Jinguo Cheng ◽  
Songcang Lin ◽  
Zhen Hu ◽  
Gang Chen ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Clinical Research ◽  
Cystatin C ◽  
Stage Ii ◽  
Serum Cystatin C ◽  
Serum Cystatin
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