scholarly journals A Quantitative Method to Measure Skin Thickness in Leg Edema in Pregnant Women Using B-Scan Portable Ultrasonography: A Comparison Between Obese and Non-Obese Women

2019 ◽  
Vol 25 ◽  
pp. 1-9 ◽  
Author(s):  
Nami Yanagisawa ◽  
Masafumi Koshiyama ◽  
Yumi Watanabe ◽  
Shigeyasu Sato ◽  
Shin-ichi Sakamoto
Keyword(s):  
Pregnant Women ◽  
Quantitative Method ◽  
Skin Thickness ◽  
Obese Women ◽  
Leg Edema ◽  
Portable Ultrasonography

The Myometrium in Pregnant Women with Obesity

2020 ◽  
Vol 19 (2) ◽  
pp. 193-200
Author(s):  
Jorge A. Carvajal ◽  
Joaquín I. Oporto
Keyword(s):  
Pregnant Women ◽  
Public Health Problem ◽  
Oxytocin Receptor ◽  
High Rate ◽  
K Channel ◽  
Obese Women ◽  
Cesarean Sections ◽  
Cholesterol Levels ◽  
Myometrial Contractility ◽  
Lower Expression

: Obesity is a worldwide public health problem, affecting at least one-third of pregnant women. One of the main problems of obesity during pregnancy is the resulting high rate of cesarean section. The leading cause of this higher frequency of cesarean sections in obese women, compared with that in nonobese women, is an altered myometrial function that leads to lower frequency and potency of contractions. In this article, the disruptions of myometrial myocytes were reviewed in obese women during pregnancy that may explain the dysfunctional labor. The myometrium of obese women exhibited lower expression of connexin43, a lower function of the oxytocin receptor, and higher activity of the potassium channels. Adipokines, such as leptin, visfatin, and apelin, whose concentrations are higher in obese women, decreased myometrial contractility, perhaps by inhibiting the myometrial RhoA/ROCK pathway. The characteristically higher cholesterol levels of obese women alter myometrial myocyte cell membranes, especially the caveolae, inhibiting oxytocin receptor function, and increasing the K+ channel activity. All these changes in the myometrial cells or their environment decrease myometrial contractility, at least partially explaining the higher rate of cesarean of sections in obese women.

Development and Evaluation of a Theory-Based App for Managing Gestational Weight Gain for Overweight and Obese Pregnant Women: A Mixed-Method Pilot Study (Preprint)

2021 ◽  
Author(s):  
Ching-Fang Lee ◽  
Li-Kang Chi ◽  
Yvonne Hsiung ◽  
Jian-Pei Huang ◽  
Chun-Wei Chang
Keyword(s):  
Physical Activity ◽  
Weight Gain ◽  
Pregnant Women ◽  
Gestational Weight Gain ◽  
Mixed Method ◽  
Moderate Intensity ◽  
Obese Women ◽  
Healthy Behavior ◽  
Gestational Weight ◽  
Methodological Guidelines

BACKGROUND Overweight and obese women’s excessive gestational weight gain (GWG) may be a health risk for both the mother and the fetus; excessive GWG leads to the retention of weight postpartum and thus obesity. Given the overwhelming number of existing pregnancy-related applications (apps), we lack only a few methodological guidelines for integrating theory, evidence and previously validated apps to help overweight and obese women manage their GWG during pregnancy. OBJECTIVE This two-phase study aimed to develop the MyHealthyWeight (MHW) app based on social-cognitive theory (SCT) and evaluate its effectiveness for overweight and obese women in helping prevent excessive GWG by enhancing adherence to optimal GWG goals and healthy behavior during pregnancy. METHODS First, we constructed and developed the MHW app based on SCT theory, and we later employed a mixed-method study to evaluate the effects of the app on overweight and obese pregnant women. RESULTS All participating overweight and obese pregnant women (100%) achieved their optimal GWG through increased self-efficacy and physical activity. Their total and moderate-intensity physical activity expenditures improved, while their sedentary and light-intensity levels of physical activity decreased. CONCLUSIONS This theory-based MHW app for weight management was greatly valued by the pregnant users. Its usefulness for health-care professionals in assisting overweight and obese pregnant women in preventing excessive GWG by promoting healthy behavior, in particular through physical exercise and a healthy diet, during pregnancy was also confirmed. CLINICALTRIAL NCT04553718

scholarly journals Placental Ras Regulates Inflammation Associated with Maternal Obesity

2018 ◽  
Vol 2018 ◽  
pp. 1-18 ◽  
Author(s):  
Stella Liong ◽  
Gillian Barker ◽  
Martha Lappas
Keyword(s):  
Protein Expression ◽  
Pregnant Women ◽  
Human Placenta ◽  
Maternal Obesity ◽  
Small Gtpase ◽  
Obese Women ◽  
Trophoblast Cells ◽  
Ras Protein ◽  
Placental Inflammation ◽  
Expression And Activity

Heightened placental inflammation and dysfunction are commonly associated in pregnant obese women compared to their pregnant lean counterparts. The small GTPase superfamily members known as the rat sarcoma viral oncogene homolog (Ras) proteins, in particular, the K-Ras and H-Ras isoforms, have been implicated to regulate inflammation. The aims were to determine the placental Ras expression and activity with maternal obesity and its role in regulating placental inflammation. Human placenta was obtained at term Caesarean section from lean and obese pregnant women to determine the effect of maternal obesity on Ras protein expression and activity. To determine the effect of Ras on inflammation induced by bacterial endotoxin LPS and proinflammatory cytokines TNF-α or IL-1β, the chemical inhibitor lonafarnib (total Ras inhibitor) and siRNA (siKRAS and siHRAS) were used. Total Ras protein expression together with combined K-Ras and H-Ras activity was significantly increased in the placenta of obese pregnant women and when stimulated with LPS, IL-1β, or TNF-α. Lonafarnib significantly suppressed LPS-, IL-1β-, or TNF-α-induced IL-6, IL-8, MCP-1, and GRO-α expression and secretion in placental tissue. Primary trophoblast cells transfected with siKRAS or siHRAS demonstrated only K-Ras silencing significantly decreased IL-1β-, TNF-α-, or LPS-induced IL-6, IL-8, and MCP-1 expression and secretion. Furthermore, siKRAS significantly reduced downstream ERK-1/2 activation induced by LPS. In trophoblast cells, ERK-1/2 signalling is required for IL-6, IL-8, MCP-1, and GRO-α secretion. These studies implicate a role for K-Ras in regulating inflammation in human placenta. Suppressing overactive placental K-Ras function may prevent adverse fetal outcomes complicated by maternal obesity.

scholarly journals Manfaat Rendaman Air Hangat dan Garam dalam Menurunkan Derajat Edema Kaki Ibu Hamil Trimester III

2020 ◽  
Vol 7 (2) ◽  
pp. 76
Author(s):  
Sawitry Sawitry ◽  
Fitria Hikmatul Ulya ◽  
Elisabet Jemsi Adepatiloy
Keyword(s):  
Pregnant Women ◽  
Quantitative Research ◽  
Mean Value ◽  
Lower Limbs ◽  
Wilcoxon Test ◽  
Warm Water ◽  
Third Trimester ◽  
Post Test ◽  
The Difference ◽  
Leg Edema

ABSTRAK Edema kaki terjadi hampir 80% dari semua kehamilan dan dapat menimbulkan ketidaknyamanan selama kehamilan seperti nyeri, merasa berat, kram pada malam hari, penebalan kulit, dan pigmentasi. Salah satu intervensi non farmakologis untuk mengurangi edema adalah rendaman air hangat dan garam yang merupakan intervensi untuk menghilangkan edema pada ekstremitas bawah  selama kehamilan. Menganalisis  pengaruh rendaman air hangat dan garam  terhadap edema kaki ibu hamil trimester III. Penelitian kuantitatif dengan metode quasy eksperimental one group pre test post test desaign. Sampel penelitian sebanyak 16 ibu hamil Trimester III dengan teknik accidental sampling. Analisis data menggunakan uji Wilcoxon. Terjadi penurunan tingkat edema kaki pada ibu hamil dengan selisih nilai tengah edema kaki sebelum 4,00 dan setelah perlakuan sebesar 0,00  .Uji Wilcoxon menunjukkan ρ value 0,000. Ada pengaruh rendaman air hangat dan garam  terhadap edema kaki ibu hamil trimester III. Kata Kunci : rendaman air hangat dan garam; edema; tungkai bawah ; ibu hamil.  THE EFFECT OF WARM WATER AND SALT IMMERSION IN DECLINING LEG EDEMA OF THIRD TRIMESTER PREGNANT WOMEN  ABSTRACT Edema of the legs occurs in almost 80% of all pregnancies and can cause discomfort during pregnancy such as pain, feeling heavy, cramps at night, skin thickening, and pigmentation. One of the non-pharmacological interventions to reduce edema is soaking in warm water and salt which is an intervention to relieve edema in the lower extremities during pregnancy. This study was to determine the effect of warm water and salt immersion in declining leg edema of third trimester pregnant women. This quantitative research used quasy experimental method one group pre test post test desaign. The total samples were 16 respondents with purposive sampling and random sampling techniques. Data analysis used the Wilcoxon test. The difference in the mean value of leg edema before 4.00 and after treatment was 0.00. The Wilcoxon test showed ρ value of 0.000. There is an effect of warm water and salt immersion on leg edema of third trimester pregnant women.   Keywords: warm water and salt soaking; edema; lower limbs; pregnant mother

scholarly journals Association between Pre-pregnant Overweight and Obesity and Periodontal Disease during Pregnancy: A Cross Sectional Study

2017 ◽  
Vol 3 (1) ◽  
pp. 1
Author(s):  
Eman Ali Abd El Moaty Sheha ◽  
Hanan Elzeblawy Hassan ◽  
Wafaa Mostafa Ahmed Gamel
Keyword(s):  
Periodontal Disease ◽  
Pregnant Women ◽  
Cross Sectional Study ◽  
Overweight And Obesity ◽  
University Hospital ◽  
Public Health Issue ◽  
Obese Women ◽  
Sectional Study ◽  
Cross Sectional ◽  
Increased Risk

Background: Obesity is considered а noteworthy public health issue in both developed & developing countries. Among the 1.5 billion overweight individuals worldwide, 300 million of them were obese women. In the general, the prevalence of maternal obesity has increased 60% in the previous two decades with nearly 1 in 3 women now entering pregnancy obese. Also, the periodontаl disease has been observed to be prevalent in pregnant women with the prevalence ranging from 20% to more than 50%, especially economically disadvantaged women.Aim: explore the relation between pre-pregnant overweight and obesity with periodontal disease during pregnancy.Subjects & Methods: cross-sectional study among 400 pregnant women were booked in the high-risk obstetric departments and the antenatal outpatient clinics at governmental general hospitals in El-Fayoum City and governmental university hospital in El-Mansoura city.Results: The mean age of pregnant women was 29.9 ± 6.2 with increase the prevalence of periodontal disease in pregnant women (83.5%). Statistically significant correlation was found between prenatal weight and periodontаl disease during pregnancy (p ≤ 0.0001) with increasing the prevalence of periodontal disease in prenatal obese women (53.2%) and over weight (39.7%) were observed in women who were in their 3rd trimester (р = 0.011). Increase prevalence of periodontal with poor oral hygiene and sedentary activity.Conclusion: increased pre-pregnancy obesity & overweight are positively correlated with periodontal disease prevalence among pregnant women, and Pregnancy itself may also be associated with аn increased risk of periodontal disease.Recommendations: Activating the role of the maternity and community health nurse in branches of Obstetrics and antenatal clinics to enhance pregnant women's knowledge regarding oral health risks of obesity & overweight.

scholarly journals Oxidative Stress, Neutrophil Elastase and Vascular Endothelial Growth Factor in Obese Pregnant Women with Preeclampsia

2019 ◽  
Vol 12 (04) ◽  
pp. 1887-1891
Author(s):  
Moushira Zakia ◽  
Taghreed Shalabi ◽  
Tamer Hussein ◽  
Mohamed Hammam ◽  
Eman Youness ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Risk Factors ◽  
Blood Pressure ◽  
Growth Factor ◽  
Pregnant Women ◽  
Neutrophil Elastase ◽  
Inflammatory Marker ◽  
Vascular Endothelial ◽  
Obese Women ◽  
Endothelial Growth Factor

Oxidative stress, inflammation, and vascular endothelial proliferation and obesity are risk factors associated with preeclampsia (PE). Thepresent study aimed to investigate the levels of malondialdehyde (MDA) as a putative circulatory marker of oxidative stress, neutrophil Elastase (NE) as inflammatory marker andvascular endothelial growth factor (VEGF) as marker for vascular permeability-enhancing activities inobese women withpreeclampsia PE and compare withnormal pregnancy women. The study was carried out on 50 pregnant obese women with PE and 50 normal pregnant women. The preeclampsia women were characterized with high blood pressure 160/110 mmHg and proteinuria. The gestational age ranged from ≥32 weeks to <37 weeks. Pre pregnancyweightwas recorded. Body mass index (BMI) was calculatedat delivery.SerumMDA, NEand VEGF were estimatedby ELISA. Significant higher levels of serum MAD,NE and VEGF were observed in obese PE patients as compared to normal controls. Our results suggested thatobesity;oxidative stress, NEandVEGFbiomarkers are risk factors for PE,emphasizing their role as feasible candidate risk markersfor cases withhigh blood pressure in early pregnancy.

scholarly journals Ketonuria Is Associated with Changes to the Abundance of Roseburia in the Gut Microbiota of Overweight and Obese Women at 16 Weeks Gestation: A Cross-Sectional Observational Study

Nutrients ◽  
2019 ◽  
Vol 11 (8) ◽  
pp. 1836 ◽  
Author(s):  
Helen Robinson ◽  
Helen Barrett ◽  
Luisa Gomez-Arango ◽  
H. David McIntyre ◽  
Leonie Callaway ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Pregnant Women ◽  
Clustering Analysis ◽  
Alpha Diversity ◽  
Microbiota Composition ◽  
Obese Women ◽  
Cross Sectional ◽  
Low Carbohydrate ◽  
Rrna Sequencing ◽  
Gut Microbiota Composition

The gut microbiome in pregnancy has been associated with various maternal metabolic and hormonal markers involved in glucose metabolism. Maternal ketones are of particular interest due to the rise in popularity of low-carbohydrate diets. We assessed for differences in the composition of the gut microbiota in pregnant women with and without ketonuria at 16 weeks gestation. Fecal samples were obtained from 11 women with fasting ketonuria and 11 matched controls. The samples were analyzed to assess for differences in gut microbiota composition by 16S rRNA sequencing. Supervised hierarchical clustering analysis showed significantly different beta-diversity between women with and without ketonuria, but no difference in the alpha-diversity. Group comparisons and network analysis showed that ketonuria was associated with an increased abundance of the butyrate-producing genus Roseburia. The bacteria that contributed the most to the differences in the composition of the gut microbiota included Roseburia, Methanobrevibacter, Uncl. RF39, and Dialister in women with ketonuria and Eggerthella, Phascolarctobacterium, Butyricimonas, and Uncl. Coriobacteriaceae in women without ketonuria. This study found that the genus Roseburia is more abundant in the gut microbiota of pregnant women with ketonuria. Roseburia is a butyrate producing bacterium and may increase serum ketone levels.

scholarly journals Factors associated with iron deficiency in pregnant women seen at a public prenatal care service

2013 ◽  
Vol 26 (4) ◽  
pp. 455-464 ◽  
Author(s):  
Rosângela Maria Souza de Camargo ◽  
Rosângela Alves Pereira ◽  
Edna Massae Yokoo ◽  
Janine Schirmer
Keyword(s):  
Iron Deficiency ◽  
Prenatal Care ◽  
Pregnant Women ◽  
Care Service ◽  
Care Facility ◽  
Excess Weight ◽  
Food Groups ◽  
Obese Women ◽  
Mato Grosso ◽  
Iron Stores

OBJECTIVE: This study aimed to determine the frequency of iron deficiency and its association with socioeconomic, obstetric, and nutritional factors in pregnant women. METHODS: This cross-sectional study included women on the second trimester of pregnancy seen at a public prenatal care facility of Cuiabá, Mato Grosso, Brazil from May 2008 to May 2009. Socioeconomic, nutritional, and obstetric data were compared with markers of iron stores. RESULTS: During the study period, 146 pregnant women met the inclusion criteria. The frequency of anemia characterized by abnormal hemoglobin level, hematocrit, and mean corpuscular volume varied from 3% to 5%. However, 11% of the women had high transferrin levels and 39% had low ferritin levels. Before pregnancy, 21% of the women were underweight and 29% were overweight or obese. During pregnancy, the percentage of overweight or obese women rose to 40%. History of miscarriages, higher gestational age, and excess weight before pregnancy were associated with markers of iron stores at abnormal levels. Consumption of specific food groups was not associated with abnormal marker levels. CONCLUSION: Serum ferritin was the most sensitive indicator of iron deficiency. Excess weight and anemia were concomitant.

scholarly journals A Higher Rate of Iron Deficiency in Obese Pregnant Sudanese Women

2017 ◽  
Vol 5 (3) ◽  
pp. 285-289 ◽  
Author(s):  
Wisal Abbas ◽  
Ishag Adam ◽  
Duria A. Rayis ◽  
Nada G. Hassan ◽  
Mohamed F. Lutfi
Keyword(s):  
Body Mass Index ◽  
Iron Deficiency ◽  
Pregnant Women ◽  
Serum Ferritin ◽  
Linear Regression Analysis ◽  
Normal Weight ◽  
Negative Association ◽  
Deficiency Anemia ◽  
Obese Women ◽  
Blood Indices

AIM: To assess the association between obesity and iron deficiency (ID).MATERIAL AND METHODS: Pregnant women were recruited from Saad Abualila Hospital, Khartoum, Sudan, during January–April 2015. Medical history (age, parity, gestational age) was gathered using questionnaire.  Weight and height were measured, and body mass index (BMI) was calculated. Women were sub-grouped based on BMI into underweight (< 18.5 kg/m^2), normal weight (18.5–24.9 kg/m^2), overweight (25–29.9 kg/m^2) and obese (≥ 30 kg/m^2). Serum ferritin and red blood indices were measured in all studied women.RESULTS: Two (0.5%), 126 (29.8%), 224 (53.0%) and 71 (16.8%) out of the 423 women were underweight, normal weight, overweight and obese, respectively. Anemia (Hb <11 g/dl), ID (ferritin <15µg/l) and iron deficiency anemia (IDA) were prevalent in 57.7%, 21.3% and 12.1%, respectively. Compared with the women with normal BMI, significantly fewer obese women were anemic [25 (35.2%) vs. 108 (85.7%), P < 0.001] and significantly higher number of obese women [25 (35.2) vs. 22 (17.5, P = 0.015] had iron deficiency. Linear regression analysis demonstrated a significant negative association between serum ferritin and BMI (– 0.010 µg/, P= 0.006).CONCLUSION: It is evident from the current findings that prevalence of anaemia and ID showed different trends about BMI of pregnant women.

scholarly journals The effectiveness of Information-Motivation and Behavioral skills (IMB) model of self-care in early pregnancy to prevent gestational diabetes mellitus in Iranian overweight and obese women: A Randomized Controlled Trial

2020 ◽  
Author(s):  
Narges Sadat Motahari-Tabari ◽  
Mahbobeh Faramarzi ◽  
Marjan Ahmad Shirvani ◽  
Afsaneh Bakhtiari ◽  
Shabnam Omidvar ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Gestational Diabetes ◽  
Pregnant Women ◽  
Controlled Trial ◽  
Fasting Blood Glucose ◽  
Intervention Group ◽  
Tolerance Test ◽  
Obese Women ◽  
Imb Model ◽  
Behavioral Skills

Abstract Background: Gestational diabetes is one of the most common metabolic dysfunction in pregnancy and as overweight and obesity are of the major risk factors, this study aimed to determine the effect of Information-Motivation and Behavioral skills (IMB) model-based counseling on preventing gestational diabetes in overweight and obese pregnant women. Methods: A randomised controlled trial (RCT) was conducted involving pregnant women who are overweight (BMI >25 to 29.9 k/gm2) or obese (BMI >30 k/gm2), at the 12 to 16 weeks gestation and recruited from the Prenatal Clinic of Rohani Educational Hospital in Babol medical university, Iran, women in the intervention group will receive a program informed four sessions by the Information-Motivation and Behavioral skills. The control group received routine care. Blood glucose was measured before and 8 weeks after the intervention. Descriptive and inferential statistics including mean, standard deviation, frequency, t-test, chi-square and ANCOVA were used. Results: The prevalence of gestational diabetes was lower in the intervention group than the routine care group (10% and 29.9%, respectively, RR=0.33, CI 95% (0.15- 0.74) p=0.004) as well as mean fasting blood glucose (d=0.28, P=0.07), and glucose tolerance test at the first and second hour (d= 0.41 and d=0.73, respectively, p<0.01). Conclusions: Our data suggest that women that IMB model-based counseling on self-care in early pregnancy in overweight and obese pregnant women can be effective in preventing gestational diabetes. Keywords: Gestational Diabetes, Obesity, Overweight, Information-Motivation-Behavioral Skills Model Name of the registry: Comparison of the effectiveness of counseling based on health promoting behaviors on fasting blood glucose and glucose tolerance test in pregnant and overweight and obese women IRCT registration number: IRCT20120125008822N3Registration date: 2018-07-05, 1397/04/14Registration timing: prospective https://en.irct.ir/trial/32150

Sign in / Sign up

Export Citation Format

Share Document