scholarly journals Circular RNA hsa-circ-0012129 Promotes Cell Proliferation and Invasion in 30 Cases of Human Glioma and Human Glioma Cell Lines U373, A172, and SHG44, by Targeting MicroRNA-661 (miR-661)

2018 ◽  
Vol 24 ◽  
pp. 2497-2507 ◽  
Author(s):  
Gang Xie
Keyword(s):  
Cell Proliferation ◽  
Cell Lines ◽  
Glioma Cell ◽  
Circular Rna ◽  
Human Glioma ◽  
Human Glioma Cell ◽  
Glioma Cell Lines ◽  
Proliferation And Invasion

scholarly journals Long Intergenic Noncoding RNA 00152 Promotes Glioma Cell Proliferation and Invasion by Interacting with MiR-16

2018 ◽  
Vol 46 (3) ◽  
pp. 1055-1064 ◽  
Author(s):  
Xin Chen ◽  
Deheng Li ◽  
Yang Gao ◽  
Wei Tang ◽  
Lao IW ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Cell Lines ◽  
Glioma Cell ◽  
Migration And Invasion ◽  
Human Glioma ◽  
Human Glioma Cell ◽  
Glioma Cell Lines ◽  
Glioma Cell Proliferation ◽  
Proliferation And Invasion

Background/Aims: Long noncoding RNAs (lncRNAs) are a novel class of protein-noncoding transcripts that are aberrantly expressed in multiple diseases including cancers. LINC00152 has been identified as an oncogene involved in many kinds of cancer; however, its expression pattern and function in human glioma remain unclear. Methods: Quantitative real-time polymerase chain reaction was carried out to measure LINC00152 expression in human glioma cell lines and tissues. CCK-8 and EdU assays were performed to assess cell proliferation, and scratch assays and Transwell assays were used to assess cell migration and invasion, respectively. Luciferase reporter assays were carried out to determine the interaction between miR-16 and LINC00152. In vivo experiments were conducted to assess tumor formation. Results: LINC00152 was found to be significantly upregulated in human glioma cell lines and clinical samples. Knockdown of LINC00152 suppressed glioma cell proliferation, migration, and invasion in vitro. In vivo assays in nude mice confirmed that LINC00152 knockdown inhibits tumor growth. Furthermore, mechanistic investigation showed that LINC00152 binds to miR-16 in a sequence-specific manner and suppresses its expression. miR-16 inhibition strongly attenuated LINC00152 knockdown–mediated suppressive effects on proliferation, migration, and invasion. Moreover, LINC00152 induced BMI1 expression by sponging miR-16; this effect further promoted glioma cell proliferation and invasion. Conclusion: We regard LINC00152 as an oncogenic lncRNA promoting glioma cell proliferation and invasion and as a potential target for human glioma treatment.

scholarly journals Long Noncoding RNA H19 Promotes Proliferation and Invasion in Human Glioma Cells by Downregulating miR-152

2018 ◽  
Vol 26 (9) ◽  
pp. 1419-1428 ◽  
Author(s):  
Lei Chen ◽  
Yuhai Wang ◽  
Jianqing He ◽  
Chunlei Zhang ◽  
Junhui Chen ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Cell Lines ◽  
Glioma Cell ◽  
Glioma Cells ◽  
Human Glioma ◽  
Human Glioma Cell ◽  
Glioma Cell Lines ◽  
Glioma Cell Proliferation ◽  
Proliferation And Invasion

miR-152 and lncRNA H19 have been frequently implicated in various cellular processes including cell proliferation, invasion, angiogenesis, and apoptosis. However, the interaction between miR-152 and H19 in glioma has never been reported. RT-qPCR was used to examine the expression of miR-152 and H19 in human glioma cell lines and normal human astrocytes (NHAs). The interaction between miR-152 and lncRNA H19 was assessed by dual-luciferase reporter assay. MTT assay and Transwell invasion assay were used to determine the proliferation and invasion of U251 and U87 cells. A xenograft tumor experiment was performed to confirm the role of H19 in vivo. The results showed that H19 expression was upregulated and miR-152 expression was downregulated in human glioma cell lines. H19 downregulation or miR-152 upregulation suppressed glioma cell proliferation and invasion in vitro. Moreover, H19 and miR-152 directly regulated each other. Furthermore, decreased miR-152 expression alleviated si-H19-induced inhibitory effects on proliferation and invasion in glioma cells. As expected, H19 silencing hindered glioma growth in vivo. Taken together, H19 promoted glioma cell proliferation and invasion by negatively regulating miR-152 expression, providing evidence for the potential application of H19 as a biomarker and therapy target for glioma.

5-lipoxygenase pathway promotes cell proliferation in human glioma cell lines

2009 ◽  
Vol 28 (11) ◽  
pp. 445-452 ◽  
Author(s):  
K. Ishii ◽  
M. Zaitsu ◽  
N. Yonemitsu ◽  
Y. Kan ◽  
Y. Hamasaki ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Cell Lines ◽  
Glioma Cell ◽  
Human Glioma ◽  
Lipoxygenase Pathway ◽  
Human Glioma Cell ◽  
Glioma Cell Lines

Human wild type p53 inhibits cell proliferation and elicits dramatic morphological changes in human glioma cell lines in vitro

1994 ◽  
Vol 127 (2) ◽  
pp. 125-133 ◽  
Author(s):  
Abderrahim Merzak ◽  
Stéphane Raynal ◽  
Joan P. Rogers ◽  
David Lawrence ◽  
Geoffrey J. Pilkington
Keyword(s):  
Cell Proliferation ◽  
Cell Lines ◽  
Glioma Cell ◽  
Morphological Changes ◽  
Human Glioma ◽  
Wild Type ◽  
Human Glioma Cell ◽  
Glioma Cell Lines ◽  
Human Wild Type

“In vitro” effect of interleukin-1 beta on human glioma cell lines: regulation of cell proliferation and IL-6 production

1992 ◽  
Vol 34 (3) ◽  
pp. 267-271 ◽  
Author(s):  
Sarah Cinque ◽  
Jean Willems ◽  
Stany Depraetere ◽  
Lea Vermeire ◽  
Marcel Joniau
Keyword(s):  
Cell Proliferation ◽  
Cell Lines ◽  
Glioma Cell ◽  
Interleukin 1 ◽  
Interleukin 1 Beta ◽  
Human Glioma ◽  
Human Glioma Cell ◽  
Glioma Cell Lines ◽  
Vitro Effect

Enhancement of temozolomide-induced apoptosis by valproic acid in human glioma cell lines through redox regulation

2011 ◽  
Vol 89 (3) ◽  
pp. 303-315 ◽  
Author(s):  
Ching-Hsein Chen ◽  
Yu-Jia Chang ◽  
Maurice S. B. Ku ◽  
King-Thom Chung ◽  
Jen-Tsung Yang
Keyword(s):  
Valproic Acid ◽  
Cell Lines ◽  
Glioma Cell ◽  
Redox Regulation ◽  
Human Glioma ◽  
Human Glioma Cell ◽  
Glioma Cell Lines ◽  
Induced Apoptosis

scholarly journals Verotoxin-1 induction of apoptosis in Gb3-expressing human glioma cell lines

2006 ◽  
Vol 5 (9) ◽  
pp. 1211-1217 ◽  
Author(s):  
David Johansson ◽  
Anders Johansson ◽  
Kjell Grankvist ◽  
Ulrika Andersson ◽  
Roger Henriksson ◽  
...  
Keyword(s):  
Cell Lines ◽  
Glioma Cell ◽  
Human Glioma ◽  
Human Glioma Cell ◽  
Glioma Cell Lines ◽  
Induction Of Apoptosis
Sign in / Sign up

Export Citation Format

Share Document