scholarly journals Diffusion Tensor Imaging in Diagnosis of Post-Traumatic Syringomyelia in Spinal Cord Injury in Rats

2018 ◽  
Vol 24 ◽  
pp. 177-182 ◽  
Author(s):  
Chao Zhang ◽  
Kai Chen ◽  
Xiuxin Han ◽  
Jiayuanyuan Fu ◽  
Patricia Douglas ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Diffusion Tensor Imaging ◽  
Diffusion Tensor ◽  
Cord Injury ◽  
Post Traumatic

scholarly journals Noninvasive diffusion tensor imaging of evolving white matter pathology in a mouse model of acute spinal cord injury

2007 ◽  
Vol 58 (2) ◽  
pp. 253-260 ◽  
Author(s):  
Joong Hee Kim ◽  
David N. Loy ◽  
Hsiao-Fang Liang ◽  
Kathryn Trinkaus ◽  
Robert E. Schmidt ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Diffusion Tensor Imaging ◽  
White Matter ◽  
Mouse Model ◽  
Diffusion Tensor ◽  
Acute Spinal Cord Injury ◽  
Cord Injury ◽  
White Matter Pathology

scholarly journals Nanoparticles guided precise transplantation of varying numbers of mesenchymal stem cells into post–traumatic syrinx in spinal cord injury rat

2018 ◽  
pp. 49-56
Author(s):  
Chao Zhang ◽  
A.Y. Morozova ◽  
V.P. Baklaushev ◽  
I.L. Gubsky ◽  
P.A. Melnikov ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Stem Cells ◽  
Spinal Cord Injury ◽  
Mesenchymal Stem Cells ◽  
Magnetic Nanoparticles ◽  
Diffusion Tensor ◽  
Cell Number ◽  
Functional Improvement ◽  
Cord Injury ◽  
Post Traumatic

Spinal cord injury (SCI) is a traumatic injury to the spinal cord which is not a consequence of the disease. Mesenchymal stem cells (MSCs) have gradually become one of the most used stem cells in research and clinic trial. Based on the previous reports employed the cells ranged from 4 • 105 to 1 • 106, the present study was performed to figure out the best number of MSCs for transplantation of the chronic SCI. Magnetic nanoparticles were used for proving the precise transplantation strategy. Using magnetic resonance imaging (MRI), diffusion tensor imaging (DTI), diffusion tensor tractography (DTT), and behavior testing evaluations, we focused the effect of varying numbers of MSCs on reducing lesion cavity and post–traumatic syrinx formation, suppressing glial scar formation, enhancing neuronal fibers remodeling, promoting axonal regeneration and sprouting, improving vascularization, ameliorating the neuronal factors expressional level, and function improvement. Magnetic nanoparticles were precisely transplanted into the post–traumatic syrinx (PTS). MSCs can restore function after chronic SCI through stimulating the regeneration and sprouting of the axons, reducing the formation of PTS. The effect of MSCs on PTS management and functional improvement post chronic SCI was cell number–dependent, and within the range of 4 • 105 to 1 • 106, 1 • 106 cells were proved to be the best dose.

Analysis of high-voltage electrical spinal cord injury using diffusion tensor imaging

2013 ◽  
Vol 260 (11) ◽  
pp. 2876-2883 ◽  
Author(s):  
Suk Hoon Ohn ◽  
Deog Young Kim ◽  
Ji Cheol Shin ◽  
Seung Min Kim ◽  
Woo-Kyoung Yoo ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Diffusion Tensor Imaging ◽  
High Voltage ◽  
Diffusion Tensor ◽  
Cord Injury

Evaluation of the effect of myelotomy on nerve function in rats with spinal cord injury by diffusion tensor imaging

2020 ◽  
pp. 028418512097518
Author(s):  
Yi Liu ◽  
Changbin Liu ◽  
Chuan Qin ◽  
Xin Zhang ◽  
Hao Feng ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Diffusion Tensor Imaging ◽  
Diffusion Tensor ◽  
Pearson Correlation ◽  
Mean Diffusivity ◽  
Motor Dysfunction ◽  
Sprague Dawley ◽  
Cord Injury ◽  
Pearson Correlation Test

Background Spinal cord injury (SCI) is a severe central nervous system injury that can generally induce different degrees of sensory and motor dysfunction Purpose To clarify the changes of diffusion tensor imaging (DTI) parameters after spinal cord myelotomy in rats with SCI. Material and Methods Eighteen Sprague Dawley (SD) rats were randomly divided into the Sham group (n=6), SCI group (n=6), and Mye group (n=6), respectively. The DTI values at 1, 3, 7, and 21 days after modeling were collected by magnetic resonance imaging (MRI). The spinal specimen at the injury site was collected on the 21st day for Nissl’s staining to assess the changes in neurons. Results The fractional anisotropy (FA) values in both the SCI group and Mye group significantly decreased. In addition, the FA values between the two groups were statistically significant ( P < 0.001). The apparent diffusion coefficient (ADC), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD) values all decreased and then increased ( P < 0.001). Pearson correlation test showed that the ADC, MD, and AD values were positively correlated with the Basso Beattie Bresnahan (BBB) score. Nissl’s staining showed a higher number of Nissl’s bodies, and deep staining of Nissl’s bodies in the Mye group, while the morphology of neurons was relatively good. The number of neurons in the Mye group was significantly higher after myelotomy compared to the SCI group ( P < 0.001). Conclusion The DTI parameters, especially ADC values, could non-invasively and quantifiably evaluate the efficacy of myelotomy for rats with SCI.

Diffusion Tensor Imaging in Acute Spinal Cord Injury: A Review of Animal and Human Studies

2019 ◽  
Vol 36 (15) ◽  
pp. 2279-2286 ◽  
Author(s):  
Mayank Kaushal ◽  
Saman Shabani ◽  
Matthew Budde ◽  
Shekar Kurpad
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Diffusion Tensor Imaging ◽  
Diffusion Tensor ◽  
Acute Spinal Cord Injury ◽  
Human Studies ◽  
Cord Injury

scholarly journals Clinical correlates of cerebral diffusion tensor imaging findings in chronic traumatic spinal cord injury

Spinal Cord ◽  
2014 ◽  
Vol 52 (3) ◽  
pp. 202-208 ◽  
Author(s):  
E A Koskinen ◽  
U Hakulinen ◽  
A E Brander ◽  
T M Luoto ◽  
A Ylinen ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Diffusion Tensor Imaging ◽  
Diffusion Tensor ◽  
Traumatic Spinal Cord Injury ◽  
Imaging Findings ◽  
Clinical Correlates ◽  
Cord Injury

scholarly journals The impact of myelination on axon sparing and locomotor function recovery in spinal cord injury assessed using diffusion tensor imaging

2013 ◽  
Vol 26 (11) ◽  
pp. 1484-1495 ◽  
Author(s):  
Tsang-Wei Tu ◽  
Joong H. Kim ◽  
Feng Qin Yin ◽  
Lyn B. Jakeman ◽  
Sheng-Kwei Song
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Diffusion Tensor Imaging ◽  
Diffusion Tensor ◽  
Locomotor Function ◽  
Function Recovery ◽  
Cord Injury ◽  
The Impact

scholarly journals Reduced Field of View Diffusion Tensor Imaging and Fiber Tractography of the Pediatric Cervical and Thoracic Spinal Cord Injury

2018 ◽  
Vol 35 (3) ◽  
pp. 452-460 ◽  
Author(s):  
Mahdi Alizadeh ◽  
Joshua Fisher ◽  
Sona Saksena ◽  
Yusra Sultan ◽  
Chris J. Conklin ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Diffusion Tensor Imaging ◽  
Diffusion Tensor ◽  
Field Of View ◽  
Fiber Tractography ◽  
Thoracic Spinal Cord ◽  
Thoracic Spinal ◽  
Cord Injury
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