scholarly journals Clinical correlates of cerebral diffusion tensor imaging findings in chronic traumatic spinal cord injury

Spinal Cord ◽  
2014 ◽  
Vol 52 (3) ◽  
pp. 202-208 ◽  
Author(s):  
E A Koskinen ◽  
U Hakulinen ◽  
A E Brander ◽  
T M Luoto ◽  
A Ylinen ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Diffusion Tensor Imaging ◽  
Diffusion Tensor ◽  
Traumatic Spinal Cord Injury ◽  
Imaging Findings ◽  
Clinical Correlates ◽  
Cord Injury

Diffusion tensor imaging in the evaluation of the long-term efficacy of HBO2 therapy in rats after traumatic spinal cord injury

2020 ◽  
pp. 435-443
Author(s):  
Yijing Zhao ◽  
◽  
Yingyan Zheng ◽  
Zebin Xiao ◽  
Jianyi iu ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Diffusion Tensor Imaging ◽  
Diffusion Tensor ◽  
Traumatic Spinal Cord Injury ◽  
Term Efficacy ◽  
Cord Injury ◽  
Hbo2 Therapy ◽  
Over Time

Objective: This study explored the feasibility of diffusion tensor imaging (DTI) in the evaluation of the long-term efficacy of hyperbaric oxygen (HBO2) therapy in rats after traumatic spinal cord injury (TSCI) with different degrees of injury. Method: Adult Sprague-Dawley rats (total n = 60) were randomly separated into three groups of mild, moderate and severe TSCI (20 rats per group). Each group was then randomly divided into TSCI and TSCI+HBO2 subgroups (10 rats per subgroup). Basso Beattie and Bresnahan (BBB) scores and DTI parameters including fractional anisotropy (FA), mean apparent diffusivity (MD), radial diffusivity (RD) and axial diffusivity (AD) were collected at pre-TSCI and at 0, six and 24 hours, and three, seven, 14, 21, 28 and 56 days post-TSCI. Two-way repeated measures analysis of variance was used for comparison between the TSCI and TSCI+HBO2 subgroups over time in the mild, moderate and severe TSCI groups. Pearson correlation analysis was applied to analyze the correlations between BBB scores and DTI parameters. Results: BBB scores, FA, MD and RD values showed significant differences between the TSCI and TSCI+HBO2 subgroups over time in the mild, moderate and severe TSCI groups (all p<0.01). FA, MD and RD values were positively correlated with BBB scores in all TSCI and TSCI+HBO2 subgroups (all p<0.05). Conclusions: DTI parameters, especially MD, could quantifiably assess the long-term efficacy of HBO2 therapy and reflect the functional recovery in rats after TSCI with different degrees of injury.

scholarly journals Diffusion Tensor Imaging at 3 Hours after Traumatic Spinal Cord Injury Predicts Long-Term Locomotor Recovery

2010 ◽  
Vol 27 (3) ◽  
pp. 587-598 ◽  
Author(s):  
Joong H. Kim ◽  
David N. Loy ◽  
Qing Wang ◽  
Matthew D. Budde ◽  
Robert E. Schmidt ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Diffusion Tensor Imaging ◽  
Diffusion Tensor ◽  
Traumatic Spinal Cord Injury ◽  
Locomotor Recovery ◽  
Cord Injury

Use of Diffusion-Tensor Imaging in Traumatic Spinal Cord Injury to Identify Concomitant Traumatic Brain Injury

2008 ◽  
Vol 89 (12) ◽  
pp. S85-S91 ◽  
Author(s):  
Corie W. Wei ◽  
Januthy Tharmakulasingam ◽  
Adrian Crawley ◽  
David M. Kideckel ◽  
David J. Mikulis ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Diffusion Tensor Imaging ◽  
Brain Injury ◽  
Diffusion Tensor ◽  
Traumatic Spinal Cord Injury ◽  
Cord Injury

scholarly journals Noninvasive diffusion tensor imaging of evolving white matter pathology in a mouse model of acute spinal cord injury

2007 ◽  
Vol 58 (2) ◽  
pp. 253-260 ◽  
Author(s):  
Joong Hee Kim ◽  
David N. Loy ◽  
Hsiao-Fang Liang ◽  
Kathryn Trinkaus ◽  
Robert E. Schmidt ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Diffusion Tensor Imaging ◽  
White Matter ◽  
Mouse Model ◽  
Diffusion Tensor ◽  
Acute Spinal Cord Injury ◽  
Cord Injury ◽  
White Matter Pathology

scholarly journals Diffusion Tensor Imaging in Diagnosis of Post-Traumatic Syringomyelia in Spinal Cord Injury in Rats

2018 ◽  
Vol 24 ◽  
pp. 177-182 ◽  
Author(s):  
Chao Zhang ◽  
Kai Chen ◽  
Xiuxin Han ◽  
Jiayuanyuan Fu ◽  
Patricia Douglas ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Diffusion Tensor Imaging ◽  
Diffusion Tensor ◽  
Cord Injury ◽  
Post Traumatic

Analysis of high-voltage electrical spinal cord injury using diffusion tensor imaging

2013 ◽  
Vol 260 (11) ◽  
pp. 2876-2883 ◽  
Author(s):  
Suk Hoon Ohn ◽  
Deog Young Kim ◽  
Ji Cheol Shin ◽  
Seung Min Kim ◽  
Woo-Kyoung Yoo ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Diffusion Tensor Imaging ◽  
High Voltage ◽  
Diffusion Tensor ◽  
Cord Injury

Evaluation of the effect of myelotomy on nerve function in rats with spinal cord injury by diffusion tensor imaging

2020 ◽  
pp. 028418512097518
Author(s):  
Yi Liu ◽  
Changbin Liu ◽  
Chuan Qin ◽  
Xin Zhang ◽  
Hao Feng ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Diffusion Tensor Imaging ◽  
Diffusion Tensor ◽  
Pearson Correlation ◽  
Mean Diffusivity ◽  
Motor Dysfunction ◽  
Sprague Dawley ◽  
Cord Injury ◽  
Pearson Correlation Test

Background Spinal cord injury (SCI) is a severe central nervous system injury that can generally induce different degrees of sensory and motor dysfunction Purpose To clarify the changes of diffusion tensor imaging (DTI) parameters after spinal cord myelotomy in rats with SCI. Material and Methods Eighteen Sprague Dawley (SD) rats were randomly divided into the Sham group (n=6), SCI group (n=6), and Mye group (n=6), respectively. The DTI values at 1, 3, 7, and 21 days after modeling were collected by magnetic resonance imaging (MRI). The spinal specimen at the injury site was collected on the 21st day for Nissl’s staining to assess the changes in neurons. Results The fractional anisotropy (FA) values in both the SCI group and Mye group significantly decreased. In addition, the FA values between the two groups were statistically significant ( P < 0.001). The apparent diffusion coefficient (ADC), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD) values all decreased and then increased ( P < 0.001). Pearson correlation test showed that the ADC, MD, and AD values were positively correlated with the Basso Beattie Bresnahan (BBB) score. Nissl’s staining showed a higher number of Nissl’s bodies, and deep staining of Nissl’s bodies in the Mye group, while the morphology of neurons was relatively good. The number of neurons in the Mye group was significantly higher after myelotomy compared to the SCI group ( P < 0.001). Conclusion The DTI parameters, especially ADC values, could non-invasively and quantifiably evaluate the efficacy of myelotomy for rats with SCI.

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