scholarly journals Volumetric and Fatty Infiltration Imbalance of Deep Paravertebral Muscles in Adolescent Idiopathic Scoliosis

2017 ◽  
Vol 23 ◽  
pp. 2089-2095 ◽  
Author(s):  
Jeng Jiang ◽  
Yichen Meng ◽  
Xinmeng Jin ◽  
Chenglin Zhang ◽  
jianquan zhao ◽  
...  
Keyword(s):  
Adolescent Idiopathic Scoliosis ◽  
Idiopathic Scoliosis ◽  
Fatty Infiltration ◽  
Paravertebral Muscles

Morphology of the Paravertebral Muscles in Adolescent Idiopathic Scoliosis

Spine ◽  
1983 ◽  
Vol 8 (5) ◽  
pp. 457-462 ◽  
Author(s):  
CARL ZETTERBERG ◽  
AMELIE ANIANSSON ◽  
GUNNAR GRIMBY
Keyword(s):  
Adolescent Idiopathic Scoliosis ◽  
Idiopathic Scoliosis ◽  
Paravertebral Muscles

scholarly journals Transforming Growth Factor-Beta (TGF-β) Signaling in Paravertebral Muscles in Juvenile and Adolescent Idiopathic Scoliosis

2014 ◽  
Vol 2014 ◽  
pp. 1-14 ◽  
Author(s):  
Roman Nowak ◽  
Magdalena Kwiecien ◽  
Magdalena Tkacz ◽  
Urszula Mazurek
Keyword(s):  
Adolescent Idiopathic Scoliosis ◽  
Idiopathic Scoliosis ◽  
Transforming Growth Factor Beta ◽  
Transforming Growth Factor ◽  
Pcr Analysis ◽  
Extracellular Region ◽  
Paravertebral Muscles ◽  
Growth Factor Beta ◽  
Genetic And Environmental Factors ◽  
Adolescent Period

Most researchers agree that idiopathic scoliosis (IS) is a multifactorial disease influenced by complex genetic and environmental factors. The onset of the spinal deformity that determines the natural course of the disease, usually occurs in the juvenile or adolescent period. Transforming growth factorsβ(TGF-βs) and their receptors, TGFBRs, may be considered as candidate genes related to IS susceptibility and natural history. This study explores the transcriptional profile of TGF-βs, TGFBRs, and TGF-βresponsive genes in the paravertebral muscles of patients with juvenile and adolescent idiopathic scoliosis (JIS and AIS, resp.). Muscle specimens were harvested intraoperatively and grouped according to the side of the curve and the age of scoliosis onset. The results of microarray and qRT-PCR analysis confirmed significantly higher transcript abundances of TGF-β2, TGF-β3, and TGFBR2 in samples from the curve concavity of AIS patients, suggesting a difference in TGF-βsignaling in the pathogenesis of juvenile and adolescent curves. Analysis of TGF-βresponsive genes in the transcriptomes of patients with AIS suggested overrepresentation of the genes localized in the extracellular region of curve concavity: LTBP3, LTBP4, ITGB4, and ITGB5. This finding suggests the extracellular region of paravertebral muscles as an interesting target for future molecular research into AIS pathogenesis.

The influence of 3D curve severity on paraspinal muscle fatty infiltration in patients with adolescent idiopathic scoliosis

2021 ◽  
Author(s):  
David B. Berry ◽  
Connor D. Grant ◽  
Christine L. Farnsworth ◽  
Erin K. Englund ◽  
Peter O. Newton ◽  
...  
Keyword(s):  
Adolescent Idiopathic Scoliosis ◽  
Idiopathic Scoliosis ◽  
Fatty Infiltration ◽  
Paraspinal Muscle ◽  
Curve Severity
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