scholarly journals Oxidative DNA Damage to Sperm Cells and Peripheral Blood Leukocytes in Infertile Men

2016 ◽  
Vol 22 ◽  
pp. 4289-4296 ◽  
Author(s):  
Kerem Taken ◽  
Hamit Hakan Alp ◽  
Recep Eryilmaz ◽  
Muhammet Irfan Donmez ◽  
Murat Demir ◽  
...  
Keyword(s):  
Dna Damage ◽  
Peripheral Blood ◽  
Oxidative Dna Damage ◽  
Sperm Cells ◽  
Peripheral Blood Leukocytes ◽  
Blood Leukocytes ◽  
Infertile Men

scholarly journals Antigenotoxic properties of anthocyanin-enriched fraction of strawberry (cv. Romina) extract on DNA damage induced by H2O2 in human peripheral blood leukocytes

2021 ◽  
Vol 71 (3) ◽  
pp. 197-206
Author(s):  
Biljana Spremo-Potparević ◽  
Andrea Čabarkapa-Pirković ◽  
Dragana Dekanski ◽  
Dijana Topalović ◽  
Vladan Bajić ◽  
...  
Keyword(s):  
Dna Damage ◽  
Peripheral Blood ◽  
Oxidative Dna Damage ◽  
Human Peripheral Blood ◽  
Antioxidant Properties ◽  
Protective Agent ◽  
Peripheral Blood Leukocytes ◽  
Blood Leukocytes ◽  
Damage Reduction

Strawberry fruit Fragaria × ananassa Duchesne, Rosaceae (cv. Romina), rich in anthocyanin polyphenols, has been demonstrated to have favorable effects on health due to its antioxidant properties. The present study investigated the antigenotoxic potential of anthocyanin enriched fraction of Romina strawberry methanolic extract (ACY) against DNA damage on human peripheral blood leukocytes, induced by hydrogen peroxide in vitro. Five concentrations of the ACY extract were used in all experiments (2.5, 5, 10, 15, 20 µg/ml). The results of the alkaline comet assay showed no genotoxic effect of the ACY. After the pre-exposure of the leukocytes to the ACY, and subsequent incubation with H2O2, a decreased number of DNA damaged cells was recorded in all the tested concentrations, compared to controls. In the posttreatment, there was a concentration-dependent DNA damage reduction, while a statistically significant decrease was achieved with 15 and 20 µg/ml concentrations. The results indicate that ACY is efficient in oxidative DNA damage reduction, and it is more potent as a post-applicative than a protective agent.

scholarly journals DNA damage in peripheral blood leukocytes in tobacco users

2014 ◽  
Vol 18 (4) ◽  
pp. 16 ◽  
Author(s):  
VenkateswaraRao Guttikonda ◽  
Rekha Patil ◽  
GS Kumar
Keyword(s):  
Dna Damage ◽  
Peripheral Blood ◽  
Peripheral Blood Leukocytes ◽  
Blood Leukocytes
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