scholarly journals Expressions of Senescence-Associated β-Galactosidase and Senescence Marker Protein-30 are Associated with Lens Epithelial Cell Apoptosis

2015 ◽  
Vol 21 ◽  
pp. 3728-3735 ◽  
Author(s):  
Dan Zhou ◽  
Dan Yin ◽  
Fang Xiao ◽  
Jie Hao
Keyword(s):  
Epithelial Cell ◽  
Cell Apoptosis ◽  
Lens Epithelial Cell ◽  
Marker Protein ◽  
Epithelial Cell Apoptosis

Down-regulation of GJA3 is associated with lens epithelial cell apoptosis and age-related cataract

2017 ◽  
Vol 484 (1) ◽  
pp. 159-164 ◽  
Author(s):  
Dongmei Su ◽  
Shanshan Hu ◽  
Lina Guan ◽  
Xinzhu Wu ◽  
Cuige Shi ◽  
...  
Keyword(s):  
Epithelial Cell ◽  
Cell Apoptosis ◽  
Lens Epithelial Cell ◽  
Down Regulation ◽  
Age Related ◽  
Epithelial Cell Apoptosis

Caspase-3 Is Actively Involved in Okadaic Acid-Induced Lens Epithelial Cell Apoptosis

2001 ◽  
Vol 266 (2) ◽  
pp. 279-291 ◽  
Author(s):  
David Wan-Cheng Li ◽  
Hua Xiang ◽  
Ying-Wei Mao ◽  
Juan Wang ◽  
Uwe Fass ◽  
...  
Keyword(s):  
Epithelial Cell ◽  
Okadaic Acid ◽  
Cell Apoptosis ◽  
Caspase 3 ◽  
Lens Epithelial Cell ◽  
Epithelial Cell Apoptosis

scholarly journals Lens epithelial cell apoptosis appears to be a common cellular basis for non-congenital cataract development in humans and animals.

1995 ◽  
Vol 130 (1) ◽  
pp. 169-181 ◽  
Author(s):  
W C Li ◽  
J R Kuszak ◽  
K Dunn ◽  
R R Wang ◽  
W Ma ◽  
...  
Keyword(s):  
Epithelial Cell ◽  
Epithelial Cells ◽  
Cell Apoptosis ◽  
Lens Epithelial Cell ◽  
Lens Epithelial Cells ◽  
Cataract Formation ◽  
Cellular Basis ◽  
Epithelial Cell Apoptosis ◽  
Cataract Development ◽  
Cataract Patients

Cataract is a major ocular disease that causes blindness in many developing countries of the world. It is well established that various factors such as oxidative stress, UV, and other toxic agents can induce both in vivo and in vitro cataract formation. However, a common cellular basis for this induction has not been previously recognized. The present study of lens epithelial cell viability suggests such a general mechanism. When lens epithelial cells from a group of 20 cataract patients 12 to 94 years old were analyzed by terminal deoxynucleotidyl transferase (TdT) labeling and DNA fragmentation assays, it was found that all of these patients had apoptotic epithelial cells ranging from 4.4 to 41.8%. By contrast, in eight normal human lenses of comparable age, very few apoptotic epithelial cells were observed. We suggest that cataract patients may have deficient defense systems against factors such as oxidative stress and UV at the onset of the disease. Such stress can trigger lens epithelial cell apoptosis that then may initiate cataract development. To test this hypothesis, it is also demonstrated here that hydrogen peroxide at concentrations previously found in some cataract patients induces both lens epithelial cell apoptosis and cortical opacity. Moreover, the temporal and spatial distribution of induced apoptotic lens epithelial cells precedes development of lens opacification. These results suggest that lens epithelial cell apoptosis may be a common cellular basis for initiation of noncongenital cataract formation.

Sign in / Sign up

Export Citation Format

Share Document