scholarly journals Treatment Efficacy of NGF Nanoparticles Combining Neural Stem Cell Transplantation on Alzheimer’s Disease Model Rats

2015 ◽  
Vol 21 ◽  
pp. 3608-3615 ◽  
Author(s):  
Yan Chen ◽  
Cuihuan Pan ◽  
Aiguo Xuan ◽  
Liping Xu ◽  
Guoqing Bao ◽  
...  
2021 ◽  
Author(s):  
Kun Jiang ◽  
Yongqi Zhu ◽  
Lei Zhang

Alzheimer’s disease (AD) is a kind of neurodegenerative disease with insidious onset and progressive progression. The etiology of AD may be related to the loss of neurons, astrocytes, and microglial in the nervous system. Exogenous stem cell transplantation has brought hope to the treatment of AD. Stem cell transplantation can reduce amyloid β-protein (Aβ) deposition and Tau phosphorylation, and provide secretory factor support to improve learning and memory deficits. The purpose of this review is to provide an overview of the relationship between different stem cell species and the treatment of AD, and also summarize current experimental stem cell therapy strategies and their potential clinical applications in the future.


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