scholarly journals New Prospects for Stem Cell Therapy in Alzheimer’s Disease

2021 ◽  
Author(s):  
Kun Jiang ◽  
Yongqi Zhu ◽  
Lei Zhang
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Stem Cell ◽  
Cell Therapy ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Stem Cell Therapy ◽  
Amyloid Β ◽  
Amyloid Β Protein ◽  
Therapy Strategies

Alzheimer’s disease (AD) is a kind of neurodegenerative disease with insidious onset and progressive progression. The etiology of AD may be related to the loss of neurons, astrocytes, and microglial in the nervous system. Exogenous stem cell transplantation has brought hope to the treatment of AD. Stem cell transplantation can reduce amyloid β-protein (Aβ) deposition and Tau phosphorylation, and provide secretory factor support to improve learning and memory deficits. The purpose of this review is to provide an overview of the relationship between different stem cell species and the treatment of AD, and also summarize current experimental stem cell therapy strategies and their potential clinical applications in the future.

Mesenchymal Stem Cell Therapy and Alzheimer’s Disease: Current Status and Future Perspectives

2020 ◽  
Vol 77 (1) ◽  
pp. 1-14 ◽  
Author(s):  
Jieun Kim ◽  
Yujeong Lee ◽  
Seulah Lee ◽  
Kipom Kim ◽  
Minjung Song ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Stem Cells ◽  
Stem Cell ◽  
Cell Therapy ◽  
Neurodegenerative Disease ◽  
Stem Cell Therapy ◽  
Amyloid Β ◽  
Research Trends ◽  
Current Status

Alzheimer’s disease (AD) is the most common progressive neurodegenerative disease worldwide, but its cause remains unclear. Although a few drugs can provide temporary and partial relief of symptoms in some patients, no curative treatment is available. Therefore, attention has been focused on research using stem cells to treat AD. Among stem cells, mesenchymal stem cells (MSCs) have been used to treat the related pathologies in animal models of AD, and other neurodegenerative disease. This review describes latest research trends on the use of MSC-based therapies in AD and its action of mechanism. MSCs have several beneficial effects. They would be specified as the reduction of neuroinflammation, the elimination of amyloid-β, neurofibrillary tangles, and abnormal protein degradation, the promotion of autophagy-associated and blood-brain barrier recoveries, the upregulation of acetylcholine levels, improved cognition, and the recovery of mitochondrial transport. Therefore, this review describes the latest research trends in MSC-based therapy for AD by demonstrating the importance of MSC-based therapy and understanding of its mechanisms in AD and discusses the limitations and perspectives of stem cell therapy in AD.

Astrocyte Reactivity in Alzheimer’s Disease: Therapeutic Opportunities to Promote Repair

2021 ◽  
Vol 18 ◽  
Author(s):  
Nazanin Mirzaei ◽  
Nicola Davis ◽  
Tsz Wing Chau ◽  
Magdalena Sastre
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Mouse Models ◽  
Neurodegenerative Disorders ◽  
Amyloid Β ◽  
Neuroprotective Effects ◽  
Synaptic Density ◽  
Inflammatory Profile

: Astrocytes are fast climbing the ladder of importance in neurodegenerative disorders, particularly in Alzheimer’s disease (AD), with the prominent presence of reactive astrocytes sur- rounding amyloid β- plaques, together with activated microglia. Reactive astrogliosis, implying morphological and molecular transformations in astrocytes, seems to precede neurodegeneration, suggesting a role in the development of the disease. Single-cell transcriptomics has recently demon- strated that astrocytes from AD brains are different from “normal” healthy astrocytes, showing dys- regulations in areas such as neurotransmitter recycling, including glutamate and GABA, and im- paired homeostatic functions. However, recent data suggest that the ablation of astrocytes in mouse models of amyloidosis results in an increase in amyloid pathology as well as in the inflammatory profile and reduced synaptic density, indicating that astrocytes mediate neuroprotective effects. The idea that interventions targeting astrocytes may have great potential for AD has therefore emerged, supported by a range of drugs and stem cell transplantation studies that have successfully shown a therapeutic effect in mouse models of AD. In this article, we review the latest reports on the role and profile of astrocytes in AD brains and how manipulation of astrocytes in animal mod- els has paved the way for the use of treatments enhancing astrocytic function as future therapeutic avenues for AD.

Allogeneic mesenchymal stem cell therapy for refractory cytopenias after hematopoietic stem cell transplantation

Transfusion ◽  
2011 ◽  
Vol 52 (5) ◽  
pp. 1086-1091 ◽  
Author(s):  
Fermin M. Sánchez-Guijo ◽  
Olga López-Villar ◽  
Lucía López-Anglada ◽  
Eva M. Villarón ◽  
Sandra Muntión ◽  
...  
Keyword(s):  
Stem Cell ◽  
Hematopoietic Stem Cell Transplantation ◽  
Mesenchymal Stem Cell ◽  
Cell Therapy ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Hematopoietic Stem Cell ◽  
Stem Cell Therapy ◽  
Hematopoietic Stem ◽  
Mesenchymal Stem Cell Therapy

scholarly journals Analysis of the Expectation of Stem Cell Therapy in Patients with Alzheimer’s Disease

2016 ◽  
Vol 15 (4) ◽  
pp. 129
Author(s):  
Seokgil Han ◽  
Hojin Choi ◽  
Young Seo Kim ◽  
Kyu-Yong Lee ◽  
Young Joo Lee ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Stem Cell ◽  
Cell Therapy ◽  
Stem Cell Therapy

P3-345: Restoration of memory in mouse models of Alzheimer's disease and neuronal loss: A new paradigm using human neural stem cell therapy

2012 ◽  
Vol 8 (4S_Part_16) ◽  
pp. P577-P578
Author(s):  
Mathew Blurton-Jones ◽  
Rahasson Ager ◽  
Joy Nerhus ◽  
Andy Agazaryan ◽  
Stephen Huhn ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Stem Cell ◽  
Cell Therapy ◽  
Neural Stem Cell ◽  
Mouse Models ◽  
Stem Cell Therapy ◽  
Neuronal Loss ◽  
New Paradigm ◽  
Human Neural Stem Cell
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