scholarly journals Effects of Long-term Exercise on Spatial Learning, Memory Ability, and Cortical Capillaries in Aged Rats

2015 ◽  
Vol 21 ◽  
pp. 945-954 ◽  
Author(s):  
Yong Tang
Keyword(s):  
Spatial Learning ◽  
Aged Rats ◽  
Memory Ability ◽  
Cortical Capillaries ◽  
Spatial Learning Memory

scholarly journals Repeated Sleep Restriction in Adolescent Rats Altered Sleep Patterns and Impaired Spatial Learning/Memory Ability

SLEEP ◽  
2012 ◽  
Vol 35 (6) ◽  
pp. 849-859 ◽  
Author(s):  
Su-Rong Yang ◽  
Hui Sun ◽  
Zhi-Li Huang ◽  
Ming-Hui Yao ◽  
Wei-Min Qu
Keyword(s):  
Spatial Learning ◽  
Sleep Restriction ◽  
Sleep Patterns ◽  
Memory Ability ◽  
Adolescent Rats ◽  
Spatial Learning Memory

scholarly journals Effects of long term high cholesterol diet on spatial learning in aged rats

2016 ◽  
Vol 4 (1) ◽  
Author(s):  
Shuang Rong ◽  
Rui Xu ◽  
Jing Cheng ◽  
Meng Chen ◽  
Chengcheng Ding ◽  
...  
Keyword(s):  
Spatial Learning ◽  
High Cholesterol Diet ◽  
Aged Rats ◽  
Cholesterol Diet ◽  
High Cholesterol

Severity-Dependent Long-Term Spatial Learning-Memory Impairment in a Mouse Model of Traumatic Brain Injury

2016 ◽  
Vol 7 (6) ◽  
pp. 512-520 ◽  
Author(s):  
Chengrui An ◽  
Xiaoyan Jiang ◽  
Hongjian Pu ◽  
Dandan Hong ◽  
Wenting Zhang ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Mouse Model ◽  
Spatial Learning ◽  
Memory Impairment ◽  
Spatial Learning Memory

Hippocampal long-term potentiation and spatial learning in the rat: effects of GABAB receptor blockade

Neuroscience ◽  
1996 ◽  
Vol 74 (2) ◽  
pp. 331-339 ◽  
Author(s):  
F.H Brucato ◽  
E.D Levin ◽  
D.D Mott ◽  
D.V Lewis ◽  
W.A Wilson ◽  
...  
Keyword(s):  
Spatial Learning ◽  
Gabab Receptor ◽  
Long Term Potentiation ◽  
Receptor Blockade ◽  
Term Potentiation

Long-term memory of a DRL task in mature and aged rats

1984 ◽  
Vol 10 (1) ◽  
pp. 39-42 ◽  
Author(s):  
Robert J. Hamm ◽  
C. Edward Dixon ◽  
Janet S. Knisely
Keyword(s):  
Long Term Memory ◽  
Aged Rats ◽  
Term Memory

Dissociation between genes activated in long-term potentiation and in spatial learning in the rat

1998 ◽  
Vol 251 (1) ◽  
pp. 41-44 ◽  
Author(s):  
G Richter-Levin ◽  
K.L Thomas ◽  
S.P Hunt ◽  
T.V.P Bliss
Keyword(s):  
Spatial Learning ◽  
Long Term Potentiation ◽  
Term Potentiation

scholarly journals Caspase-1/IL-1β represses membrane transport of GluA1 by inhibiting the interaction between Stargazin and GluA1 in Alzheimer’s disease

2021 ◽  
Vol 27 (1) ◽  
Author(s):  
Xunhu Gu ◽  
Hanjun Wu ◽  
Yuqin Xie ◽  
Lijun Xu ◽  
Xu Liu ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Membrane Transport ◽  
Learning And Memory ◽  
Spatial Learning ◽  
Senile Plaque ◽  
Spatial Learning And Memory ◽  
Memory Ability ◽  
Caspase 1 ◽  
Plaque Deposition

Abstract Background Alzheimer's disease is a neurodegenerative disease. Previous study has reported that caspase-1/IL-1β is closely associated with Alzheimer's disease. However, the biological role of caspase-1/IL-1β in Alzheimer's disease has not been fully elucidated. This study aimed to explore the mechanism of action of caspase-1/IL-1β in Alzheimer's disease. Methods Mouse hippocampal neurones were treated with Aβ1-42 to induce Alzheimer's disease cell model. APP/PS1 mice and Aβ1-42-induced hippocampal neurones were treated with AC-YVAD-CMK (caspase-1 inhibitor). Spatial learning and memory ability of mice were detected by morris water maze. Flow cytometry, TUNEL staining, Thioflavin S staining and immunohistochemistry were performed to examine apoptosis and senile plaque deposition. Enzyme linked immunosorbent assay and western blot were performed to assess the levels of protein or cytokines. Co-Immunoprecipitation was performed to verify the interaction between Stargazin and GluA1. Results AC-YVAD-CMK treatment improved spatial learning and memory ability and reduced senile plaque deposition of APP/PS1 mice. Moreover, AC-YVAD-CMK promoted membrane transport of GluA1 in APP/PS1 mice. In vitro, Aβ1-42-induced hippocampal neurones exhibited an increase in apoptosis and a decrease in the membrane transport of GluA1, which was abolished by AC-YVAD-CMK treatment. In addition, Stargazin interacted with GluA1, which was repressed by caspase-1. Caspase-1/IL-1β inhibited membrane transport of GluA1 by inhibiting the interaction between Stargazin and GluA1. Conclusions Our data demonstrate that caspase-1/IL-1β represses membrane transport of GluA1 by inhibiting the interaction between Stargazin in Alzheimer's disease. Thus, caspase-1/IL-1β may be a target for Alzheimer's disease treatment.

scholarly journals Spatial learning and long-term memory impairments in RasGrf1 KO, Pttg1 KO, and double KO mice

2018 ◽  
Vol 8 (11) ◽  
pp. e01089 ◽  
Author(s):  
Lara Manyes ◽  
Sarah Holst ◽  
Manuel Lozano ◽  
Eugenio Santos ◽  
Alberto Fernandez-Medarde
Keyword(s):  
Spatial Learning ◽  
Long Term Memory ◽  
Term Memory ◽  
Memory Impairments
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