scholarly journals Serum and Synovial Fluid Levels of CCL18 are Correlated with Radiographic Grading of Knee Osteoarthritis

2015 ◽  
Vol 21 ◽  
pp. 840-844 ◽  
Author(s):  
Guohui Yang
Keyword(s):  
Synovial Fluid ◽  
Knee Osteoarthritis ◽  
Fluid Levels ◽  
Radiographic Grading

scholarly journals Association between synovial fluid levels of aggrecan ARGS fragments and radiographic progression in knee osteoarthritis

2010 ◽  
Vol 12 (6) ◽  
pp. R230 ◽  
Author(s):  
Staffan Larsson ◽  
Martin Englund ◽  
André Struglics ◽  
L Stefan Lohmander
Keyword(s):  
Synovial Fluid ◽  
Knee Osteoarthritis ◽  
Radiographic Progression ◽  
Fluid Levels

scholarly journals Synovial fluid levels of bradykinin correlate with biochemical markers for cartilage degradation and inflammation in knee osteoarthritis

2013 ◽  
Vol 21 (11) ◽  
pp. 1774-1780 ◽  
Author(s):  
F. Bellucci ◽  
S. Meini ◽  
P. Cucchi ◽  
C. Catalani ◽  
A. Nizzardo ◽  
...  
Keyword(s):  
Synovial Fluid ◽  
Knee Osteoarthritis ◽  
Biochemical Markers ◽  
Cartilage Degradation ◽  
Fluid Levels

scholarly journals Relationship between Investigative Biomarkers and Radiographic Grading in Patients with Knee Osteoarthritis

2009 ◽  
Vol 2009 ◽  
pp. 1-4 ◽  
Author(s):  
Eduardo Anitua ◽  
Mikel Sánchez ◽  
Maria de la Fuente ◽  
Juan Azofra ◽  
Mar Zalduendo ◽  
...  
Keyword(s):  
Growth Factor ◽  
Synovial Fluid ◽  
Knee Osteoarthritis ◽  
Principal Component ◽  
Matrix Metalloproteases ◽  
Analysis Of Covariance ◽  
Radiographic Severity ◽  
Structural Deterioration ◽  
Igf I ◽  
Radiographic Grading

Objective. To examine new investigative biomarkers and their relevance for radiographic severity in knee osteoarthritis.Methods. The group comprised 63 patients with 73 knees examined. Patients were divided according to radiographic severity to allow for comparison of biomarker levels. Hyaluronic acid (HA), matrix metalloproteases (MMP-1, MMP-3 and MMP-13), tissue inhibitors of metalloproteases (TIMP-1 and TIMP-2), platelet-derived growth factor (PDGF-AB), transformed growth factor (TGF-β), vascular endothelial growth factor (VEGF), hepatocyte growth factor (HGF) and insulin-like growth factor (IGF-I) were measured on synovial fluid and in plasma releasate at a single time point. Principal component analysis (PCA) followed by analysis of covariance were applied to evaluate data.Results. Four different groups of biomarker were identified in plasma releasates. The first (platelet number, PDGF-AB and TGF-β) and second groups (HA and IGF-I) were related to radiographic severity,P=.005andP=.022, respectively. The third (MMP-1 and TIMP-2) and fourth groups (MMP-3 and TIMP-1) represented the catabolic balance, but were not associated to radiographic grading. Three different clusters of biomarkers were found in synovial fluid but did not show any significant association to radiographic grading.Conclusions. New imaging approaches to assess structural deterioration and correlation with biomarker levels are warranted to advance in OA research.

scholarly journals Synovial Complement Factors in Patients with Periprosthetic Joint Infection after Undergoing Revision Arthroplasty of the Hip or Knee Joint

Diagnostics ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 434
Author(s):  
Frank Sebastian Fröschen ◽  
Sophia Schell ◽  
Matthias Dominik Wimmer ◽  
Gunnar Thorben Rembert Hischebeth ◽  
Hendrik Kohlhof ◽  
...  
Keyword(s):  
Synovial Fluid ◽  
Multiple Regression ◽  
Complement System ◽  
Periprosthetic Joint Infection ◽  
Joint Infection ◽  
Expression Patterns ◽  
Factor H ◽  
Low Grade ◽  
Complement Factors ◽  
Fluid Levels

The role and diagnostic value of the synovial complement system in patients with low-grade periprosthetic joint infection (PJI) are unclear. We sought to evaluate, for the first time, the usefulness of synovial complement factors in these patients by measuring the individual synovial fluid levels of complement factors (C1q, C3b/iC3b, C4b, C5, C5a, C9, factor B, factor D, factor H, factor I, properdin, and mannose-binding lectin [MBL]). The patients (n = 74) were classified into septic (n = 28) and aseptic (n = 46). Receiver-operator characteristic curves and a multiple regression model to determine the feasibility of a combination of the tested cytokines to determine the infection status were calculated. The synovial fluid levels of C1q, C3b/C3i, C4b, C5, C5a, MBL, and properdin were significantly elevated in the PJI group. The best sensitivity and specificity was found for C1q. The multiple regression models revealed that the combination of C1q, C3b/C3i, C4b, C5, C5a, and MBL was associated with the best sensitivity (83.3%) and specificity (79.2%) for a cutoff value of 0.62 (likelihood ratio: 4.0; area under the curve: 0.853). Nevertheless, only a combined model showed acceptable results. The expression patterns of the complement factors suggested that PJI activates all three pathways of the complement system.

scholarly journals Synovial fluid but not plasma interleukin-8 is associated with clinical severity and inflammatory markers in knee osteoarthritis women with joint effusion

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
María García-Manrique ◽  
Joan Calvet ◽  
Cristóbal Orellana ◽  
Antoni Berenguer-Llergo ◽  
Silvia Garcia-Cirera ◽  
...  
Keyword(s):  
Synovial Fluid ◽  
Knee Osteoarthritis ◽  
Correlation Coefficient ◽  
Inflammatory Markers ◽  
Partial Correlation ◽  
Statistical Significance ◽  
Clinical Severity ◽  
Joint Effusion ◽  
Cross Sectional ◽  
Partial Correlation Coefficient

AbstractSeveral cytokines and adipokines are related to clinical severity and progression in knee osteoarthritis. The aim of this study was to evaluate the associations of IL-8 with clinical severity and with local and systemic adipokines and cytokines. This is a Cross-sectional study including 115 women with symptomatic primary knee osteoarthritis with ultrasound-confirmed joint effusion. Age, symptoms duration and body mass index were collected. Radiographic severity was evaluated according to Kellgren–Lawrence. Pain and disability were assessed by Lequesne and Knee injury and Osteoarthritis Outcome Score pain, symptoms and function scales. Three inflammatory markers and five adipokines were measured by ELISA in serum and synovial fluid. Partial correlation coefficient (PCC) and corresponding 95% confidence interval were used to evaluate association. Synovial fluid IL-8 was significantly associated with clinical severity scales. After controlling for potential confounders, associations measured by a Partial Correlation Coefficient (PCC) remained essentially unaltered for Lequesne (PCC = 0.237), KOOS pain (PCC = − 0.201) and KOOS symptoms (PCC = − 0.209), KOOS function (PCC = − 0.185), although the later did not reach statistical significance. Also in synovial fluid samples, associations were found between IL-8 and TNF (PCC = 0.334), IL6 (PCC = 0.461), osteopontin (PCC = 0.575), visfatin (PCC = 0.194) and resistin (PCC = 0.182), although significance was not achieved for the later after statistical control for confounders. None of these associations were detected in serum. In conclusion, IL-8 was associated with clinical severity, inflammatory markers and adipokines in synovial fluid, but not in blood. Although the reported associations are weak to moderate in magnitude, these findings reinforce the notion that local and not systemic inflammation is more relevant to clinical severity in knee OA women with joint effusion.

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